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Niladri Sinha

@2primehydroxyl.bsky.social

250 followers 330 following 21 posts

Assistant Professor @ University of Utah | interested in ribosomes and translational control in health and disease https://sinha.biochem.utah.edu

sinha.biochem.utah.edu

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Niladri Sinha @2primehydroxyl.bsky.social · Aug 21

I am delighted to share that I have started my lab in the Dept. of Biochemistry @uofubiochem.bsky.social at the University of Utah @utah.edu. My laboratory will study key aspects of protein synthesis and translational control in healthy and diseased states. #RNAsky sinha.biochem.utah.edu

The Sinha Lab

The Sinha lab studies key aspects of protein synthesis and translational control in healthy and diseased states. We study the multifaceted roles of ribosomes as critical sensors of cellular stress.

sinha.biochem.utah.edu

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Niladri Sinha @2primehydroxyl.bsky.social · Aug 30

Thanks Kate!

Niladri Sinha @2primehydroxyl.bsky.social · Aug 29

If you are a motivated and curious scientist eager to drive independent projects within a collaborative environment, please do not hesitate to reach out at [email protected]. Kindly re-post this opportunity amongst your professional networks.

Niladri Sinha @2primehydroxyl.bsky.social · Aug 29

This is a unique opportunity to lead exciting projects and play an active role in shaping the lab culture, with a chance to apply a multidisciplinary toolkit (biochemistry, proteomics, genetics, and structural biology) to address exciting questions in translational control.

Niladri Sinha @2primehydroxyl.bsky.social · Aug 29

We have an opening for a Postdoctoral Fellow to join us in exploring fundamental questions at the interface of protein synthesis defects and stress-responsive signaling pathways. utah.peopleadmin.com/postings/187... #RNAsky

Post Doc Res Assoc

Postdoc with a primary duty consisting research-related work. Required to meet FLSA threshold to be paid on a salaried basis, otherwise employment record will convert to hourly.

utah.peopleadmin.com

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Niladri Sinha @2primehydroxyl.bsky.social · Aug 27

Thanks Junjie!

Niladri Sinha @2primehydroxyl.bsky.social · Aug 27

Thanks Michael!

Niladri Sinha @2primehydroxyl.bsky.social · Aug 27

Thanks Kamena!

Niladri Sinha @2primehydroxyl.bsky.social · Aug 23

Thanks Leo!

Niladri Sinha @2primehydroxyl.bsky.social · Aug 23

Likewise - thanks Brenda!

Niladri Sinha @2primehydroxyl.bsky.social · Aug 23

Thanks Charles!

Niladri Sinha @2primehydroxyl.bsky.social · Aug 22

Thanks Daniel!

Niladri Sinha @2primehydroxyl.bsky.social · Aug 21

Thanks Andi!

Niladri Sinha @2primehydroxyl.bsky.social · Aug 21

Thanks Judi!

Niladri Sinha @2primehydroxyl.bsky.social · Aug 21

Thanks Heather!

Niladri Sinha @2primehydroxyl.bsky.social · Aug 21

Thanks Ahmad!

Niladri Sinha @2primehydroxyl.bsky.social · Aug 21

It is an honor to return to the institution where I began my scientific journey. As I embark on establishing my lab, I approach this opportunity with excitement and humility. My goal is to train the next generation of scientists, paying forward the mentorship and support that shaped my career.

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Niladri Sinha @2primehydroxyl.bsky.social · Aug 21

I take this opportunity to thank my postdoc and PhD advisors, Rachel Green and Brenda Bass @bbass.bsky.social who took great care to train me well, to my funding agencies NIGMS and @jcchildsfund.bsky.social for supporting my work, and to my family and close friends for their unconditional support.

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Niladri Sinha @2primehydroxyl.bsky.social · Aug 21

The lab will employ multidisciplinary approaches to study cellular responses to translation #stress and #proteotoxicity. We seek to identify quality control and signaling pathways triggered by ribotoxic stress and develop therapeutic strategies to target these pathways in #cancer and #aging cells.

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Niladri Sinha @2primehydroxyl.bsky.social · Aug 21

We are hiring at all levels, so please help spread the word! #RNAsky #ribosomes #signaling #translation sinha.biochem.utah.edu/join

Join — The Sinha Lab

We welcome curiosity-driven individuals excited to make foundational discoveries aimed at understanding and combating defects in translational control and proteostasis in a dynamic, collaborative, and...

sinha.biochem.utah.edu

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Niladri Sinha @2primehydroxyl.bsky.social · Aug 21

The Sinha Lab

The Sinha lab studies key aspects of protein synthesis and translational control in healthy and diseased states. We study the multifaceted roles of ribosomes as critical sensors of cellular stress.

sinha.biochem.utah.edu

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Reposted by Niladri Sinha

Quanta Magazine @quantamagazine.bsky.social · Jul 18

“What a [sunburned] cell is trying to do is make decisions about whether to live or die based on how damaged the DNA is… but amazingly, it’s the RNA that signals that. That’s the remarkable observation.” — Rachel Green, biologist at Johns Hopkins University.
www.quantamagazine.org/rna-is-the-c...

Portrait of RNA biologist Rachel Green at John Hopkins University.

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Reposted by Niladri Sinha

Beckmann Lab @beckmannlab.bsky.social · May 26

We are happy to share that our snR30 story is finally out in @natureportfolio.nature.com 🥳 We report the first structure of a H/ACA snoRNP acting in ribosome synthesis thereby providing a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. 👇👇👇

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Reposted by Niladri Sinha

Julian Stingele @jstingele.bsky.social · Feb 20

Happy to share our review on the cellular responses to RNA damage 🥂

Congrats to joined first authors Jacqueline Cordes & @shubozhao.bsky.social

www.cell.com/cell/fulltex...

Cellular responses to RNA damage

RNA plays a central role in protein biosynthesis and performs diverse regulatory and catalytic functions, making it essential for all processes of life. Like DNA, RNA is constantly subjected to damage...

www.cell.com

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Reposted by Niladri Sinha

Eugene Valkov @eugenevalkov.bsky.social · Feb 12

Latest work from our next door neighbors! #RNAsky #RNAbiology

Molecular Cell @cp-molcell.bsky.social · Feb 12

Online Now: The integrated stress response regulates 18S nonfunctional rRNA decay in mammals

The integrated stress response regulates 18S nonfunctional rRNA decay in mammals

To maintain translational fidelity, cells degrade decoding-incompetent ribosomes through the 18S nonfunctional rRNA decay (NRD) pathway. Coria et al. demonstrate that the concerted actions of GCN2, RNF10, and RIOK3 lead to a block in translation…

dlvr.it

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Reposted by Niladri Sinha

Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · Dec 13

The life of each of us began when a sperm and an egg came together. But what happens at a molecular level?

Our latest work in Cell led by @vdeneke.bsky.social & Andreas Blaha reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/11)

www.cell.com/cell/fulltex...

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