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Reposted by Eugene Valkov

Derek Lowe @dereklowe.bsky.social · 11h

I don’t think I’ve ever had more fun in the lab than when I was making MOFs myself (and trying to use them for small-molecule X-ray structure determination). So let me celebrate by posting a few of the MOF crystals I prepared:

Bright green transparent metal-organic framework crystals prepared with copper and a “multipronged” carboxylic acid ligand. The crystals formed blocky roughly rectangular pieces with some very large emerald-like chunks.

Pink/red transparent metal-organic framework crystals prepared with cobalt and a “multipronged” carboxylic acid ligand. The crystals formed as a mixture of long rectangular types and aggregated chunks.

Purple transparent metal-organic framework crystals prepared with cobalt and a “multipronged” carboxylic acid ligand. The crystals formed long slightly blocky needles.

Clear transparent metal-organic framework crystals prepared with zirconium and a “multipronged” carboxylic acid ligand. The crystals formed chunky hexagons.

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Reposted by Eugene Valkov

The New York Times @nytimes.com · 1d

Fred Ramsdell was parked at a campground in Montana on Monday when his wife suddenly started shouting. He first thought that maybe she had seen a grizzly bear. Instead, she had regained cell service and had seen a flood of text messages with the same news. “You just won the Nobel Prize!” she yelled.

Winning a Nobel Prize Interrupted His Off-the-Grid Vacation

Fred Ramsdell found out about his Nobel Prize nearly 12 hours after it was announced because he was on vacation in the Rockies.

nyti.ms

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Eugene Valkov @eugenevalkov.bsky.social · 1d

MS Copilot / Llama 3 / ChatGPT

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Reposted by Eugene Valkov

eLife @elife.bsky.social · 2d

High-resolution #CryoET provides ‘compelling’ evidence for the true 3D architecture of glutamatergic synapses: a complex ‘synaptoplasm’ rather than the textbook postsynaptic density.
buff.ly/hOYKjHH

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Reposted by Eugene Valkov

Briggs Group @briggsgroup.bsky.social · 2d

The mechanistic basis of cargo selection during Golgi maturation. From Rebecca Taylor, @katciazynska.bsky.social, @jggkaufman.bsky.social & @grigorytagiltsev.bsky.social at @mpibiochem.bsky.social with David Owen and Sean Munro's group @cellbiol-mrclmb.bsky.social | www.science.org/doi/10.1126/...

The mechanistic basis of cargo selection during Golgi maturation

Resident proteins of the Golgi recycle in vesicles and the protein GOLPH3 enables the COPI vesicle coat to accomplish this.

www.science.org

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Reposted by Eugene Valkov

Ryan Flynn @raflynn5.bsky.social · 2d

Lead by postdoc in the lab Ruiqi Ge and in collaboration with Bob Coffey’s lab, we are happy to share rPAL-seq for rapid and sensitive sequencing based profiling of glycoRNAs @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

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Eugene Valkov @eugenevalkov.bsky.social · 3d

We need an ‘Alone’-style video clip if you want our pity

Reposted by Eugene Valkov

Jan-Hannes Schaefer @jhschaef.bsky.social · 3d

Helical Reconstruction of Amyloids in cryoSPARC?
We present guidelines, limitations & future perspectives for processing amyloids in cryoSPARC @structurabio.bsky.social.
Great collaboration of the Kelly Lab and @landerlab.bsky.social #cryoEM #amyloid www.biorxiv.org/content/10.1...

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Reposted by Eugene Valkov

Nigella Lawson @nigella.bsky.social · 4d

It’s Kanelbullens Dag, that’s to say, Cinnamon Bun Day in Sweden. And while I mean no disrespect to Norway and Iceland, who also mark this day, it’s Swedish Cinnamon Buns that are #RecipeOfTheDay!
www.nigella.com/recipes/swed...

Swedish Cinnamon Buns

Swedish Cinnamon Buns are not radically different from other cinnamon buns (and do see my Norwegian Cinnamon Buns), but they do diverge in one fundamental way: rather than having the fluffiness of, sa...

www.nigella.com

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Reposted by Eugene Valkov

Victor Tatarskiy @greenrat.bsky.social · 6d

Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass...
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky

On the left - western blot of B16F10 cells wt and KO for CDK8. Our in house produced antibodies give a lot of unspecific bands. On the right same probes with antibodies preincubated with fixed CDK8 KO cells - there is a specific band and faint unspecific bands, which can be probably eliminated with increase of amount of KO cells.

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Eugene Valkov @eugenevalkov.bsky.social · 5d

👀

bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 6d

De novo design of RNA and nucleoprotein complexes https://www.biorxiv.org/content/10.1101/2025.10.01.679929v1

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Reposted by Eugene Valkov

Kristen DeAngelis 🏳️‍🌈🏳️‍⚧️🍉 @kristenobacter.bsky.social · 6d

UMass Amherst Microbiology is hiring a tenure-track virologist. Come work with me! 🦠🧪
careers.umass.edu/amherst/en-u...

Details - Assistant Professor - Virology | Human Resources | UMass Amherst

careers.umass.edu

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Reposted by Eugene Valkov

Richard Sever @richardsever.bsky.social · 7d

Another record month for bioRxiv - and further evidence the pandemic spike+dip was just that and growth continues. Thanks to all involved and that includes 🫵

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Reposted by Eugene Valkov

Samara Reck-Peterson @samreckpeterson.bsky.social · 9d

We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...

Join our Faculty | Department of Biochemistry & Biophysics

Call for applications:We invite applications for a tenure-track Assistant Professor position in the newly established Department of Biochemistry and Biophysics. We are conducting an open search for ou...

biochem.weill.cornell.edu

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Reposted by Eugene Valkov

Soragni:Lab @alice.soragnilab.com · 9d

What incredible news today. I feel so grateful to have worked closely with Tony over the years and to have witnessed firsthand his vision, energy, and commitment to advancing functional precision medicine. I cannot think of a steadier (and more needed) force at the NCI at this time /n

The Society for Functional Precision Medicine @thesfpm.bsky.social · 9d

We want to congratulate our President, Dr. Tony Letai, on his appointment as Director of the NCI. This announcement marks an historic moment for cancer research. Dr. Letai has been a tireless advocate and visionary leader for functional precision medicine 🧵

www.nih.gov/news-events/...

Secretary Kennedy Swears in Dr. Anthony Letai as Director of the National Cancer Institute

Dr. Letai will serve as NCI’s 18th director.

www.nih.gov

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Eugene Valkov @eugenevalkov.bsky.social · 9d

Yes, but this is also what made your writing human..

Eugene Valkov @eugenevalkov.bsky.social · 10d

I had a collaborator once who routinely used ! or ? for email replies.

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Eugene Valkov @eugenevalkov.bsky.social · 10d

PMID: 38864435 and 38530656

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Reposted by Eugene Valkov

Markus Hafner @markushafnerrna.bsky.social · 11d

The specific motif built up by these two RBPs cannot be identified by studying each of them in isolation, so one important question we would like to raise is: How many RBPs form heteromultimeric complexes with specificity other than the sum of the individual RBPs?

Markus Hafner @markushafnerrna.bsky.social · 11d

This work was spearheaded by Masataka Suzawa in my (NIAMS) and Chen Qiu in Traci Hall’s lab (NIEHS IRP) and initiated together with Masashi Yamaji’s group at Cincinnati Children’s. Wonderful collaboration with @eugenevalkov.bsky.social and Vittorio Sartorelli.

Markus Hafner @markushafnerrna.bsky.social · 11d

www.biorxiv.org/content/10.1...

Delighted to share the story of two germline RBPs - one with little (DND1) and one with no (NANOS3) intrinsic sequence-specificity - that together build a continuous RNA binding surface recognizing a 7-mer (AUGAAUU) in target mRNA 3’UTRs, leading to deadenylation.

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Eugene Valkov @eugenevalkov.bsky.social · 11d

Check this out all you RBP aficionados! #RNAsky #RNAbiology

Markus Hafner @markushafnerrna.bsky.social · 11d

www.biorxiv.org/content/10.1...

Delighted to share the story of two germline RBPs - one with little (DND1) and one with no (NANOS3) intrinsic sequence-specificity - that together build a continuous RNA binding surface recognizing a 7-mer (AUGAAUU) in target mRNA 3’UTRs, leading to deadenylation.

The DND1-NANOS3 complex shapes the primordial germ cell transcriptome via a heptanucleotide sequence in mRNA 3'UTRs

The RNA-binding proteins DND1 and NANOS3 are essential for primordial germ cell survival. Their co-immunoprecipitation and overlapping loss-of-function phenotypes suggest joint function, yet how they ...

www.biorxiv.org

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Eugene Valkov @eugenevalkov.bsky.social · 11d

An amazing opportunity with a great mentor

Lori Passmore @lapassmore.bsky.social · 11d

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM.

Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩
#RNA #cryoEM

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Reposted by Eugene Valkov

eLife @elife.bsky.social · 11d

A new #CryoET study shows that the protein ZapD helps organise FtsZ filaments into stable ring-like structures in building bacterial division machinery.
buff.ly/saLPqJM

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Eugene Valkov @eugenevalkov.bsky.social · 11d

If you see this, post a bridge

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Eugene Valkov @eugenevalkov.bsky.social · 13d

In other exciting news

Anthony Letai of Dana-Farber is front-runner to lead National Cancer Institute www.statnews.com/2025/09/24/n... via @statnews.com

Anthony Letai of Dana-Farber is front-runner to lead National Cancer Institute

www.statnews.com

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Eugene Valkov @eugenevalkov.bsky.social · 13d

Exciting things coming to NCI in Frederick
www.nih.gov/news-events/...

NIH establishes nation's first dedicated organoid development center to reduce reliance on animal modeling

The Standardized Organoid Modeling Center aims to produce standardized protocols for organoid research, addressing reproducibility challenges.

www.nih.gov

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