👏 Huge congratulations to Olgerta Asko, who led this work, and to our fantastic collaborators at @unioslo-ritmo.bsky.social, @ucberkeleyofficial.bsky.social cial.bsky.social, and @oushf.bsky.social sky.social.
🙏 Special thanks to the patients who made this research possible.

👩‍🔬👨‍🔬 Together, these results provide electrophysiological and causal evidence that the human prefrontal cortex predicts future sounds through distinct, time-ordered roles of OFC and LPFC.
Read the full preprint here 👉 doi.org/10.1101/2025...

Intracranial EEG shows expectancy modulations in the prefrontal cortex:
🧠 OFC earlier
🧠 LPFC later
(This was measured via high-frequency activity, a marker of local brain activity)

Connectivity analyses reveal bidirectional exchange, with the first lead by OFC.

#iEEG #PredictiveProcessing #HFA

Lesion evidence indicates distinct roles:
🧠 Orbitofrontal cortex (OFC) damage abolishes sensitivity to expectancy.
🧠 Lateral prefrontal cortex (LPFC) damage shows only modest, non-significant effects compared to controls.
(Shown using #CNV #ERP that tracks anticipation)

#BrainLesion #Prediction

In an auditory local–global deviance detection task, we found that the brain tracks sound regularities to anticipate when a rare deviant sequence will occur.
⚡ Participants detected deviants faster when they were expected.

#PredictiveProcessing

Nice work Antonino and colleagues!
We have a recent paper addressing a similar issue that you might find interesting
doi.org/10.1038/s415...

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Thanks to our fantastic team and collaborators across Oslo, Cambridge, Berkeley, and Buenos Aires!

📄 Read the full paper: doi.org/10.1038/s415...