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Selinexor is a covalent inhibitor of the nuclear export receptor exportin 1 (XPO1). A new paper reveals that selinexor mediates XPO1 degradation through an allosteric molecular glue mechanism
www.nature.com/articles/s41...
www.nature.com/articles/s41...
SINE compounds activate exportin 1 degradation through an allosteric mechanism - Nature Chemical Biology
Selinexor is a covalent inhibitor of the nuclear export receptor exportin 1 (XPO1). Wing, Fung and Kwanten et al. found that selinexor mediates XPO1 degradation through an allosteric molecule glue mec...
www.nature.com
December 3, 2025 at 9:15 PM
Selinexor is a covalent inhibitor of the nuclear export receptor exportin 1 (XPO1). A new paper reveals that selinexor mediates XPO1 degradation through an allosteric molecular glue mechanism
www.nature.com/articles/s41...
www.nature.com/articles/s41...