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Alessio Bricca @abricca.bsky.social · Jul 28

To dispel the misconception that exercise therapy wears down knee cartilage, clinicians should proactively address these concerns when treating patients with knee #osteoarthritis

open.spotify.com/episode/4JVh...

Ep 232: Exercise therapy "wears down" my joint - myth or fact? With Dr Alessio Bricca

JOSPT Insights · Episode

open.spotify.com

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Reposted by Alessio Bricca

Alessio Bricca @abricca.bsky.social · Jun 30

Exercise therapy and self-management support are more effective than usual care alone in improving health-related quality of life at 12 months in adults with multimorbidity, without compromising safety. #multimorbidity

@erc.europa.eu @natmed.nature.com @sdu.dk

🧵

www.nature.com/articles/s41...

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Alessio Bricca @abricca.bsky.social · Jul 15

Managing #multimorbidity (two or more chronic health conditions) is one of the biggest challenges in healthcare today. It affects daily life, mental wellbeing, and overall functioning.

We have some good news www.nature.com/articles/s41...

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Alessio Bricca @abricca.bsky.social · Jul 15

@exerciseworks.bsky.social 🙏

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Alessio Bricca @abricca.bsky.social · Jul 15

The most effective #digital health interventions for promoting #physicalactivity in individuals with chronic conditions include #exercise combined with self-management, delivered via mixed technologies, or #web #app platforms.

pubmed.ncbi.nlm.nih.gov/40639802/

@ispah.org

Effect of Components and Delivery Modes of Digital Health Interventions Targeting Physical Activity in People With a Chronic Condition or Multimorbidity: A Systematic Review and Component Network Meta...

The most effective digital health interventions for promoting physical activity in individuals with chronic conditions include exercise combined with self-management, delivered via mixed technologies,...

pubmed.ncbi.nlm.nih.gov

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Alessio Bricca @abricca.bsky.social · Jul 10

Even small increases in moderate-to-vigorous physical activity (MVPA) appear to be associated with low-grade inflammation in individuals with multimorbidity.

onlinelibrary.wiley.com/doi/10.1002/...

Secondary analysis of the #MOBILIZE trial published Nature Medicine lnkd.in/eHQ3kxUU

Device‐Based Physical Activity and Low‐Grade Inflammation in People With Multimorbidity: Cross‐Sectional Baseline Analysis From the MOBILIZE Trial

Physical activity (PA) has anti-inflammatory effects, but its impact on individuals with multimorbidity (two or more chronic conditions) is unclear. We examined the association between device-measure...

onlinelibrary.wiley.com

Alessio Bricca @abricca.bsky.social · Jul 3

Getting ready for #ECSS

I’ll be talking about exercise for people with multiple chronic conditions and its impact on inflammation, lipids, blood pressure, triglycerides, and cholesterol.

From a secondary analysis of the #MOBILIZE trial.

www.nature.com/articles/s41...

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Alessio Bricca @abricca.bsky.social · Jul 2

The Illusion of Simplicity in Therapeutic Exercise

Therapeutic exercise requires personalization, supervision, and continuous adaptation.

Read how we took this into account in our Nature Medicine paper www.nature.com/articles/s41...

Exercise therapy and self-management support for individuals with multimorbidity: a randomized and controlled trial - Nature Medicine

The authors report findings from the MOBILIZE trial, which found that exercise therapy and self-management support improved patient-reported quality of life in individuals with multiple chronic condit...

www.nature.com

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Reposted by Alessio Bricca

Daniel Drucker @danieljdrucker.bsky.social · Jun 30

#Exercise continues to be the best medicine. A personalized exercise therapy and self-management support program is more effective than usual care alone in improving health-related quality of life at 12 months in adults with multimorbidity @naturemedicine.bsky.social www.nature.com/articles/s41...

Exercise therapy and self-management support for individuals with multimorbidity: a randomized and controlled trial - Nature Medicine

The authors report findings from the MOBILIZE trial, which found that exercise therapy and self-management support improved patient-reported quality of life in individuals with multiple chronic condit...

www.nature.com

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Reposted by Alessio Bricca

Pills of Science🧬🦋 @mattscie.bsky.social · Jul 1

Dopo 12 mesi, chi ha seguito il programma (terapia fisica e supporto all'autogestione) ha riportato una qualità della vita relativa alla salute migliore rispetto a chi ha seguito solo le cure abituali, senza ⬆️ i rischi per la salute in persone affette da più patologie croniche. 1/2

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Reposted by Alessio Bricca

Forsknings- og implementeringsenheden PROgrez @progrez.bsky.social · Jun 30

New research from the MOBILIZE project, just published in Nature Medicine, shows that an exercise therapy + self-management program = better quality of life for people with multimorbidity.

www.nature.com/articles/s41...

#Science #Multimorbidity #Healthcare #NatureMedicine #MOBILIZE

Exercise therapy and self-management support for individuals with multimorbidity: a randomized and controlled trial - Nature Medicine

The authors report findings from the MOBILIZE trial, which found that exercise therapy and self-management support improved patient-reported quality of life in individuals with multiple chronic condit...

www.nature.com

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Reposted by Alessio Bricca

Pills of Science🧬🦋 @mattscie.bsky.social · Jul 1

Necessari ulteriori studi di conferma per indagare anche la rilevanza clinica di tale differenza tra i gruppi. Ottimo lavoro @abricca.bsky.social e considerate caldamente l'esercizio fisico come uno dei "farmaci" più potenti per la nostra salute: un investimento per il futuro! 2/2 💪🏼🔥

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Alessio Bricca @abricca.bsky.social · Jul 1

Grazie @mattscie.bsky.social per contribuire a diffondere questo messaggio!

Il nostro trial #MOBILIZE è il primo che dimostra che si può migliorare la qualità di vita in questi pazienti 🤞

La strada è ancora lunga ma la direzione è giusta!✅

www.nature.com/articles/s41...

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Reposted by Alessio Bricca

Sportrix A. Birklbauer @sportrixanita.bsky.social · Jun 30

Exercise therapy - still too underrepresented in many countries and in health providers catalogues…
www.nature.com/articles/s41...

Exercise therapy and self-management support for individuals with multimorbidity: a randomized and controlled trial - Nature Medicine

The authors report findings from the MOBILIZE trial, which found that exercise therapy and self-management support improved patient-reported quality of life in individuals with multiple chronic condit...

www.nature.com

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Alessio Bricca @abricca.bsky.social · Jun 30

10/10 Full text Open Access 👇

www.nature.com/articles/s41...

Exercise therapy and self-management support for individuals with multimorbidity: a randomized and controlled trial - Nature Medicine

The authors report findings from the MOBILIZE trial, which found that exercise therapy and self-management support improved patient-reported quality of life in individuals with multiple chronic condit...

www.nature.com

Alessio Bricca @abricca.bsky.social · Jun 30

9/10 Thanks for reading this thread and don't forget to read the full text of the paper for more info.

If you find it useful please share it!

Follow my profile @abricca.bsky.social for more on exercise and health in people with chronic conditions.

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Alessio Bricca @abricca.bsky.social · Jun 30

8/10 The takeaway:

While more research is needed to understand the full impact, this study gives hope that tailored exercise therapy and self-management programs can improve life for those living with multimorbidity. #MOBILIZEtrial #multimrobidity

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Alessio Bricca @abricca.bsky.social · Jun 30

7/10 So what does this mean?

A personalized mix of exercise therapy and self-management support might help people with multiple chronic conditions feel better—without adding risk.

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Alessio Bricca @abricca.bsky.social · Jun 30

6/10 Importantly, there were no major safety concerns. Both groups had similar numbers of serious health events—so the program didn’t increase risk. ✅

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Alessio Bricca @abricca.bsky.social · Jun 30

5/10 📈 The results?

People in the program group had a statistically significant improvement in HRQoL of life compared to the usual care group.

They also rated their own health more positively. Other outcomes like physical function and mental health were similar across groups.

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Alessio Bricca @abricca.bsky.social · Jun 30

4/10 Participants were randomly assigned to one of two groups:

🔹 Usual care alone
🔹 Usual care + 12-week program of personalized exercise and support for managing health.

The development of the 12-week program can be found here.

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Alessio Bricca @abricca.bsky.social · Jun 30

3/10 We asked: Could exercise therapy and self-management support improve life for people with multimorbidity, beyond what usual care alone offers?

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Alessio Bricca @abricca.bsky.social · Jun 30

2/10 Managing multimorbidity—when someone has two or more long-term health conditions—is tough.

It affects daily life, mental health, and overall wellbeing. But proven treatments to improve quality of life are still lacking.

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Alessio Bricca @abricca.bsky.social · Jun 30

Exercise therapy and self-management support are more effective than usual care alone in improving health-related quality of life at 12 months in adults with multimorbidity, without compromising safety. #multimorbidity

@erc.europa.eu @natmed.nature.com @sdu.dk

🧵

www.nature.com/articles/s41...

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Reposted by Alessio Bricca

Pills of Science🧬🦋 @mattscie.bsky.social · Jun 29

L'esercizio fisico ha un potente effetto antinfiammatorio, aumenta la stabilità del genoma, riduce la senescenza e migliora le funzioni cognitive e l'immunità. Tutti benefici che rendono l'esercizio fisico il "farmaco" più potente disponibile. Ed è gratis! 🧪
www.cell.com/cell/abstrac...

Systematic profiling reveals betaine as an exercise mimetic for geroprotection

Elucidating the multi-faceted health effects of exercise in humans identifies kidney-derived betaine as an exercise mimetic acting as a TBK1 inhibitor with anti-inflammatory and geroprotective activit...

www.cell.com

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