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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 5h

Super interesting
🆕💫Do Aminopenicillins Have a Role in Treating Ampicillin-Resistant Enterococcus UTIs? #idsky
academic.oup.com/ofid/article...

Do Aminopenicillins Have a Role in Treating Ampicillin-Resistant Enterococcus UTIs?

Abstract. Urinary tract infections (UTIs) caused by Enterococcus species are a frequent clinical challenge. The rising prevalence of ampicillin resistance

academic.oup.com

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 10h

What’s in a name?” Even microbes carry stories. @cmicomms.bsky.social
is launching a new series exploring the people behind eponymous organisms—those whose names live on through microbes like Escherichia or Pasteurella. Open call for submissions #idsky
www.sciencedirect.com/science/arti...

The person behind the name – an open call for articles in a new series for CMI Communications

www.sciencedirect.com

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 7d

There is still a widespread belief that fever is harmful and that it should be
treated regardless of the underlying cause, which is not supported by clinical data.
🆕💫 Review: Fever in sepsis revisited: Is a little heat what we need? #idsky
academic.oup.com/ofid/article...

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Reposted by Antibiotic Steward 🅱️C🆔🅿️🌟

Damien BARRAUD MD @damienbarraudmd.bsky.social · 12d

Intéressant...
Jamais vu encore en vrai..
Gentil rappel de toujours examiner les patients complètement, même si un diagnostic de choc sur pneumonie ou tableau abdominal semblant évident

Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 13d

Hypervirulent Klebsiella pneumoniae
(hvKP ) is a life-threatening pathogen that requires prompt clinical recognition!
🆕💫Tips for intinsvists: Hypervirulent Klebsiella pneumoniae
Delays kill eyes - and sometimes patients! #IDsky #EMIMCC
link.springer.com/article/10.1...

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 13d

hvKP is a life-& vision-threatening pathogen that should be promptly recognized
The triad of liver abscess + bacteremia + endophthalmitis should prompt immediate suspicion
Endophthalmitis is a medical emergency in septic patients with visual symptoms
Delays kill eyes and sometimes patients #microsky

Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 13d

Hypervirulent Klebsiella pneumoniae
(hvKP ) is a life-threatening pathogen that requires prompt clinical recognition!
🆕💫Tips for intinsvists: Hypervirulent Klebsiella pneumoniae
Delays kill eyes - and sometimes patients! #IDsky #EMIMCC
link.springer.com/article/10.1...

3

Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 13d

Hypervirulent Klebsiella pneumoniae
(hvKP ) is a life-threatening pathogen that requires prompt clinical recognition!
🆕💫Tips for intinsvists: Hypervirulent Klebsiella pneumoniae
Delays kill eyes - and sometimes patients! #IDsky #EMIMCC
link.springer.com/article/10.1...

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 14d

Cryptococcus neoformans and C. gattii represent encapsulated yeasts which have become increasingly common CNS pathogens during the enlarging age of the immunocompromised host
🆕💫 Review: Pain is in the Brain with the Sugar-Coated Killer #idsky
academic.oup.com/jid/article/...

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 14d

However, surveillance levels remain inadequate in central America and the Caribbean, eastern Europe, and the WHO African, Eastern Mediterranean, and South-East Asia regions.

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 14d

🚨WHO global surveillance (19–22) shows 🔼 gonococcal AMR:
🔴Ceftriaxone 39%↓susceptibility/resistance
🔴Cefixime 50% R
🔴Azithro 88% R
🔴Cipro 99% R
⚠️ Gonorrhoea could become untreatable due to high AMR levels
New hope: oral zoliflodacin & gepotidacin #idsky
www.thelancet.com/journals/lan...

WHO global gonococcal antimicrobial surveillance programmes, 2019–22: a retrospective observational study

Global AMR surveillance conducted by WHO is expanding and, in selected countries, improving through standardisation and quality assurance, as well as implementation of extragenital sampling, test of c...

www.thelancet.com

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 14d

📢WHO emphasizes there is currently no conclusive scientific evidence confirming a possible link between autism & use of acetaminophen (aka paracetamol) during pregnancy
A robust,extensive evidence base exists showing childhood vaccines do not cause autism #idsky
www.who.int/news/item/24...

WHO statement on autism-related issues

The World Health Organization (WHO) emphasizes that there is currently no conclusive scientific evidence confirming a possible link between autism and use of acetaminophen (also known as paracetamol) ...

www.who.int

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 15d

Oh finally blue sky added a bookmark function #idsky

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · Sep 3

🆕💫Navigating the Muddled Middle:
A Case-Based Exploration of Oral β-Lactams for Systemic Gram-Negative Infections
The authors explore the utility of oral β-lactams for treatment of systemic GN infections through 3 hypothetical case scenarios #idsky #EMIMCC
academic.oup.com/ofid/article...

Navigating the Muddled Middle: A Case-Based Exploration of Oral β-Lactams for Systemic Gram-Negative Infections

We describe 3 common scenarios where oral β-lactams may be used for systemic gram-negative infections, and through a coupling of patient cases, we provide

academic.oup.com

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · Sep 2

Rapid diagnostic tests combined with individualised decision-making improve the selection of antibiotic therapy. Rapid de-escalation to narrow-spectrum monotherapy and shortening of the duration of therapy should be the rule. #IDsky #EMIMCC

Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · Sep 2

🆕🔥State of art review with many🌟s
+ Prof. Jason Roberts
Antibiotic therapy for severe bacterial infections
🟢When to start and not to start antibiotics?
🟢Mon vs combo Abx
🟢PK/PD principles
🟢Drug–drug inx
A #mustread article for ID professional #idsky
link.springer.com/article/10.1...

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · Sep 2

🆕🔥State of art review with many🌟s
+ Prof. Jason Roberts
Antibiotic therapy for severe bacterial infections
🟢When to start and not to start antibiotics?
🟢Mon vs combo Abx
🟢PK/PD principles
🟢Drug–drug inx
A #mustread article for ID professional #idsky
link.springer.com/article/10.1...

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · Aug 29

Klebsiella pneumoniae remains a notorious bug that keeps challenging us in clinical practice—its resistance mechanisms are complex and relentless. This article offers valuable insights. A must-read for the ID community—please share. #idsky

Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · Aug 29

Recent years have seen a dramatic rise in carbapenem-resistant K. pneumoniae which is now recognized as one of the most formidable MDR pathogens worldwide.
🆕🔥The mechanisms of antibiotic resistance & drug resistance transmission of Klebsiella pneumoniae #idsky
www.nature.com/articles/s41...

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · Aug 29

Recent years have seen a dramatic rise in carbapenem-resistant K. pneumoniae which is now recognized as one of the most formidable MDR pathogens worldwide.
🆕🔥The mechanisms of antibiotic resistance & drug resistance transmission of Klebsiella pneumoniae #idsky
www.nature.com/articles/s41...

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Reposted by Antibiotic Steward 🅱️C🆔🅿️🌟

josh farkas 💊 @pulmcrit.bsky.social · Aug 28

nice!!

I need to read the study but it’s consistent with PROPHY-VAP which supports its validity.

https://emcrit.org/pulmcrit/prophy-vap/

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · Aug 28

🆕💫PROTECT RCT
Ceftriaxone to prevent early-onset pneumonia in comatose patients after out-of-hospital cardiac arrest: a pilot randomized controlled trial and resistome assessment (PROTECT) #IDsky #EMIMCC @pulmcrit.bsky.social
journal.chestnet.org/article/S001...

Ceftriaxone to prevent early-onset pneumonia in comatose patients after out-of-hospital cardiac arrest: a pilot randomized controlled trial and resistome assessment (PROTECT)

This trial was inconclusive regarding the impact of ceftriaxone prophylaxis to reduce the incidence of EOP after OHCA but ceftriaxone was associated with less frequent administration of open-label ant...

journal.chestnet.org

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · Aug 27

ICU length of stay was lower in the prolonged infusion patients compared with intermittent infusion.
mean difference [MD] −2.18, 95% CI −3.09 to −1.27) and extended infusion subgroup (NEI = 68, NII = 70, Fig. 6, MD −2.61, 95% CI −3.6 to –1.61

Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · Aug 27

Compared to intermittent infusion, the prolonged infusion, both continuous and extended infusion, of beta-lactam antibiotics was not associated with statistically significant improvements in mortality, clinical cure rate, microbiological cure rate, and rate of adverse events

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · Aug 27

🆕💫Systematic review and meta-analysis of RCTs with 🌟 Professor Roberts
Continuous or extended vs intermittent infusions of beta-lactam antibiotics in ICU patients with pneumonia #IDsky #EMIMCC
journals.asm.org/doi/10.1128/...

Continuous or extended vs intermittent infusions of beta-lactam antibiotics in ICU patients with pneumonia: a systematic review and meta-analysis of randomized controlled trials | Antimicrobial Agents...

Pneumonia is one of the most common nosocomial infections in the intensive care unit (ICU), with reported morbidity ranging from 6.8% to 68% (1, 2) and high mortality rates between 20.9% and 65% (2–4)...

journals.asm.org

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · Aug 25

🆕🔥Streptococcal endocarditis: a meta-analysis of species dependant risk by 🌟s @drtoddlee.bsky.social
🌟Updated figure 🌟Infective endocarditis prevalence of streptococcal species vs. proportion of streptococcal species bacteraemia #idsky #EMIMCC
www.sciencedirect.com/science/arti...

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · Aug 14

🆕🔥Prospective,multinational PK study by 🌟 Prof. Roberts
Meropenem & pip/tazo optimised dosing regimens for critically ill patients receiving RRT
Dosing nomograms developed to inform dosing for different RRT settings, urine outputs & target conc #idsky
link.springer.com/article/10.1...

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · Aug 13

Finally published
🆕🔥DOTS RCT
Among participants with complicated S aureus bacteremia who achieved blood culture clearance, dalbavancin was not superior to standard therapy for achieving a more desirable outcome at day 70 #idsky
jamanetwork.com/journals/jam...

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Reposted by Antibiotic Steward 🅱️C🆔🅿️🌟

Brad Spellberg @bradspellberg.bsky.social · Aug 12

#5/5 You have not actually prevented any infections. You simply suppressed colonization growth from non-sterile sites. We are clear in our Discussion that the studies found a statistical reduction in infections that was likely not a true reduction in infections. The trials were poorly designed.

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