ajtevelthuis.bsky.social
AJ te Velthuis
@ajtevelthuis.bsky.social
280 followers 200 following 9 posts
Assistant Professor at Princeton University. RNA polymerases, RNA viruses, mutations, and innate immune responses. Funded by NIH, Wellcome, NSF. https://tevelthuislab.scholar.princeton.edu
tevelthuislab.scholar.princeton.edu
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ajtevelthuis.bsky.social
AJ te Velthuis @ajtevelthuis.bsky.social · Aug 8
Now out in Science Advances: www.science.org/doi/10.1126/...
www.science.org
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efodor.bsky.social
Ervin Fodor @efodor.bsky.social · May 26
There is still time to apply; join our team to work on influenza virus replication mechanisms!
efodor.bsky.social
Ervin Fodor @efodor.bsky.social · May 7
Exciting job opportunities!

Two postdoc positions are available in the Fodor Lab at
@dunnschool.bsky.social to study influenza virus transcription, genome replication, nuclear export and assembly.

More info: my.corehr.com/pls/uoxrecru...
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karishmabisht.bsky.social
Karishma Bisht @karishmabisht.bsky.social · May 20
Excited to share our latest preprint in which we integrate mathematical modeling with experimental approaches to investigate how ⬆️ temperature influences aberrant RNA synthesis and innate immunity in flu infection 🦠
ajtevelthuis.bsky.social
AJ te Velthuis @ajtevelthuis.bsky.social · May 20
Flu infection => temperature⬆️ => NP levels⬇️ => aberrant RNAs⬆️ => interferon⬆️. Elegant modeling and experimental work by @karishmabisht.bsky.social and @danielweilandt.bsky.social! Preprint: www.biorxiv.org/content/10.1...
www.biorxiv.org
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ajtevelthuis.bsky.social
AJ te Velthuis @ajtevelthuis.bsky.social · May 20
Flu infection => temperature⬆️ => NP levels⬇️ => aberrant RNAs⬆️ => interferon⬆️. Elegant modeling and experimental work by @karishmabisht.bsky.social and @danielweilandt.bsky.social! Preprint: www.biorxiv.org/content/10.1...
www.biorxiv.org
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bnonews.com
BNO News @bnonews.com · Apr 8
3-year-old girl dies from H5N1 bird flu in Mexico’s first human case bnonews.com/index.php/20...
3-year-old girl dies from H5N1 bird flu in Mexico’s first human case
A three-year-old girl who became Mexico’s first confirmed human case of H5N1 avian influenza has died, the country’s Health Ministry announced. It marks Mexico’s first fatality linked to the bird flu ...
bnonews.com
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ajtevelthuis.bsky.social
AJ te Velthuis @ajtevelthuis.bsky.social · Mar 1
Only works through Safari for me. Nothing with Firefox, Duckduckgo, Chrome.. Europe PMC works fine fortunately
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ajtevelthuis.bsky.social
AJ te Velthuis @ajtevelthuis.bsky.social · Mar 1
Seems browser dependent for me
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bmeyer.bsky.social
Björn Meyer @bmeyer.bsky.social · Mar 1
Yep, Pubmed here down as well
tattooed-bug.bsky.social
Maureen Laroche, PhD, FRES @tattooed-bug.bsky.social · Mar 1
OK so pubmed is down for me... Can we freak out now?
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kgandersen.bsky.social
Kristian G. Andersen @kgandersen.bsky.social · Feb 27
It is worth paying close attention to the new bill "Dangerous Viral Gain of Function Research Moratorium Act" introduced by Senator Roger Marshall.

If enacted, it will effectively stop all of virological research, including for vaccines.

www.marshall.senate.gov/wp-content/u...

🧵👇
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larryladd.bsky.social
Larry Ladd @larryladd.bsky.social · Mar 1
We are at risk of abandoning “a deal where the government provides funding, and in exchange it gets products, research, national security, prestige, and the next generation of qualified scientists.” #academicsky
www.princeton.edu/news/2025/02...
The partnership that drives America’s leadership in medical discovery: How it works and what’s at stake
With federal support, universities produce world-changing discoveries and the next generation of exquisitely well-trained researchers.
www.princeton.edu
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dieworkwear.bsky.social
derek guy @dieworkwear.bsky.social · Mar 1
FWIW, it's perhaps worth noting that when Benjamin Franklin visited France between 1776 and 1778 to ask for military support for the then-new-formed United States of America, he wore a coonskin cap. "Proper" French court attire at this time was a powdered wig.
Drawing of Benjamin Frankling wearing a coonskin cap. Franklin being received by the French court in 1778. The French are in powdered wigs.
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mjcrockett.bsky.social
M.J. Crockett @mjcrockett.bsky.social · Feb 27
My new piece in @theguardian.com

Techno-optimism is human pessimism.

www.theguardian.com/commentisfre...
AI is ‘beating’ humans at empathy and creativity. But these games are rigged | MJ Crockett
Research pitting people against AI systems gives AI an edge by asking us to perform in machine-like ways
www.theguardian.com
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ajtevelthuis.bsky.social
AJ te Velthuis @ajtevelthuis.bsky.social · Feb 26
Congrats Alistair!
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alistairrussell.bsky.social
Alistair Russell @alistairrussell.bsky.social · Feb 26
Despite everything, I still really want to celebrate the wonderful folks in my group, so I hope it is ok if i write about our latest work.

I am very proud of all the authors, and our collaborators, on our work just published in Nature communications.
www.nature.com/articles/s41...
Analysis of NS2-dependent effects on influenza PB1 segment extends replication requirements beyond the canonical promoter - Nature Communications
The eight genomics segments of Influenza A virus exhibit different replication dynamics during infection. Here, the authors show through a range of mutant libraries of HA and PB1 segments that Influen...
www.nature.com
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Reposted by AJ te Velthuis
oliviermoncorge.bsky.social
oliviermoncorge.bsky.social @oliviermoncorge.bsky.social · Feb 17
Negative-Strand RNA Virus meeting #NSV2025 registration is now open!
Visit www.negativestrandvirus.org/home
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ajtevelthuis.bsky.social
AJ te Velthuis @ajtevelthuis.bsky.social · Jan 5
Excited to share this new preprint showing that non-canonical influenza virus transcripts are produced in a sequence/RNA structure-dependent manner on aberrant RNAs: www.biorxiv.org/content/10.1...
A two-step mechanism for RIG-I activation by influenza virus mini viral RNAs
Influenza A virus (IAV) non-canonical replication products can be bound by various host pathogen sensors, including retinoic acid-inducible gene I (RIG-I). However, it is not clear why non-canonical I...
www.biorxiv.org
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biorxivpreprint.bsky.social
bioRxivpreprint @biorxivpreprint.bsky.social · Jan 5
A two-step mechanism for RIG-I activation by influenza virus mini viral RNAs https://www.biorxiv.org/content/10.1101/2025.01.04.630666v1
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socialinfluenza.bsky.social
Ed Hutchinson @socialinfluenza.bsky.social · Dec 18
They can all be downloaded from here: cvr-engagement.co.uk/virus-snowfl..., except for...
Virus Snowflakes — CVR Engagement
cvr-engagement.co.uk
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npariente.bsky.social
Nonia Pariente @npariente.bsky.social · Dec 18
What we are waiting for to wake up?

"The patient had been in contact with sick and dead birds in backyard flocks, the Centers for Disease Control and Prevention said"

@adamjkucharski.bsky.social discusses effective outbreak response @plosbiology.org plos.io/3ZnpcnE

apnews.com/article/bird...
🧪
Health officials say Louisiana patient is first severe bird flu case in US
A person in Louisiana has the first severe illness caused by bird flu in the U.S., health officials said Wednesday.
apnews.com
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alistairrussell.bsky.social
Alistair Russell @alistairrussell.bsky.social · Nov 17
We have another new preprint up!
www.biorxiv.org/content/10.1...
Novel CRITR-seq approach reveals influenza transcription is modulated by NELF and is a key event precipitating an interferon response
Transcription of interferons upon viral infection is critical for cell-intrinsic innate immunity. This process is influenced by many host and viral factors. To identify host factors that modulate inte...
www.biorxiv.org
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alistairrussell.bsky.social
Alistair Russell @alistairrussell.bsky.social · Nov 17
(this is very consistent with another work from @ajtevelthuis.bsky.social which we were happy to contribute to, found at www.biorxiv.org/content/10.1...)
Influenza A virus transcription generates capped cRNAs that activate RIG-I
During influenza A virus (IAV) infection, host pathogen receptor retinoic acid-inducible gene I (RIG-I) detects the partially complementary, 5’-triphosphorylated ends of the viral genome segments and ...
www.biorxiv.org
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ajtevelthuis.bsky.social
AJ te Velthuis @ajtevelthuis.bsky.social · Nov 13
We have found a capped flu RNA that was hiding in plain sight. In our preprint we show how this RNA activates RIG-I through a non-canonical mechanism. Fantastic work by Liza Elshina and many thanks to collaborators @alistairrussell.bsky.social and Joe Marcotrigiano! biorxiv.org/content/10.1...
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alistairrussell.bsky.social
Alistair Russell @alistairrussell.bsky.social · Sep 11
We have a new preprint up!
www.biorxiv.org/content/10.1...
Efficient genome replication in influenza A virus requires NS2 and sequence beyond the canonical promoter
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
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ajtevelthuis.bsky.social
AJ te Velthuis @ajtevelthuis.bsky.social · Jan 12
Transient RNA structures contribute to highly pathogenic flu emergence! Fantastic work by Mathis Funk and Mathilde Richard now on BioRxiv: biorxiv.org/content/10.1... For supporting data see: science.org/doi/10.1126/...
Transient RNA structures underlie highly pathogenic avian influenza virus genesis
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
biorxiv.org
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ajtevelthuis.bsky.social
AJ te Velthuis @ajtevelthuis.bsky.social · Nov 4
Excited to share a preprint on quantifying aberrant viral RNAs using Cas13. We reveal surprisingly reproducible kinetics of individual influenza virus mvRNAs in infection and detect mvRNAs even in clinical samples! www.biorxiv.org/content/10.1...
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