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Alex K @alexkzis.bsky.social · Aug 12

Excited to share that our paper is out in @natcomms.nature.com
🔗 rdcu.be/ez3Gt
We uncover how MICAL1 regulates actin dynamics to enhance VWF–GPIbα binding in platelets.

Big thanks to all co-authors & collaborators !
@hithlabinserm1176.bsky.social @echardlab-pasteur.bsky.social

F-actin disassembly by the oxidoreductase MICAL1 promotes mechano-dependent VWF-GPIbα interaction in platelets

Nature Communications - To stop bleeding from an injured vessel, platelets adhere and form a clot despite high shear stress from the flow. Here, the authors show that platelet actin disassembly is...

rdcu.be

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Alex K @alexkzis.bsky.social · Jun 27

Farewell party for Jean. End of an amazing PhD and the beginning of a new story in @immunothrombosis.bsky.social lab in Munich. #research #phd #postdoc #mentorship

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Alex K @alexkzis.bsky.social · Jun 5

A special day: Jean Solarz, my first PhD student, successfully defended his thesis. Proud of all the work accomplished! Thks to jury members.

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Jun 5

Huge congratulations to Dr Jean Solarz for brilliantly defending his PhD today! And to his supervisors @alexkzis.bsky.social and Frederic Adam.
We are very proud of you!

A big thank you to all the committee members Prof N Ajzenberg, Dr MP Gratacap, Dr G Romet-Lemonne, Dr Leon, and Dr Ho-Tin-Noe

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Alex K @alexkzis.bsky.social · May 25

Incredible trail ! 45 km, 2000 D+/2600 D- #utgc Ultra Trail du Grand Colombier, Ain

Alex K @alexkzis.bsky.social · Apr 4

Bravo Jean Solarz for your presentation at the French Society of Hematology on MICAL1 @hithlabinserm1176.bsky.social #sfh #Hemsky #hemesky

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Reposted by Alex K

Société Française de Thrombose et d'Hémostase @sfthemostase.bsky.social · Apr 2

Plenary session at the SFH with Prof. Marie-Christine Alessi invited for a talk on phenotype/genotype in platelet disorders with Hana Raslova as moderator. #hemesky #hemsky #sfh

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Reposted by Alex K

Dianne @dianvanderwaldr.bsky.social · Mar 25

It's all about glycans! 🍡🍢 #glycosky
Our @isth.org SSC paper is now!

Alex K @alexkzis.bsky.social · Mar 25

We have worked for 2 years with @dianvanderwaldr.bsky.social to propose a protocol for platelet desialylation, and we are excited to now share it. Communication from the ISTH SSC Platelet Physiology. - Journal of Thrombosis and Haemostasis www.jthjournal.org/article/S153... #hemsky #hemesky

Consensus protocol for platelet desialylation (β-galactose exposure) quantification using lectins by flow cytometry: Communication from the ISTH SSC Subcommittee on Platelet Physiology.

Platelets contain many heterogeneous carbohydrates (glycans): often capped by sialic acid. The removal of sialic acid (desialylation) is important for platelet function and clearance, leading to novel...

www.jthjournal.org

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Alex K @alexkzis.bsky.social · Mar 25

We have worked for 2 years with @dianvanderwaldr.bsky.social to propose a protocol for platelet desialylation, and we are excited to now share it. Communication from the ISTH SSC Platelet Physiology. - Journal of Thrombosis and Haemostasis www.jthjournal.org/article/S153... #hemsky #hemesky

Consensus protocol for platelet desialylation (β-galactose exposure) quantification using lectins by flow cytometry: Communication from the ISTH SSC Subcommittee on Platelet Physiology.

Platelets contain many heterogeneous carbohydrates (glycans): often capped by sialic acid. The removal of sialic acid (desialylation) is important for platelet function and clearance, leading to novel...

www.jthjournal.org

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Alex K @alexkzis.bsky.social · Mar 22

Finisher of Ecotrail of Paris, 46 km! Château de Versailles->Tour Eiffel #Ecotrail #paris #trail #trailerunning #ecotrailparis

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Alex K @alexkzis.bsky.social · Mar 19

Great collaboration with Hana Raslova and @alessandrabalduini.bsky.social teams on BSS signaling defect! Recently published. @hithlabinserm1176.bsky.social

haematologica.org/article/view...

Early View | Haematologica

haematologica.org

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Reposted by Alex K

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Mar 3

In the @hithlabinserm1176.bsky.social we love to collaborate! Check out this very interesting paper by @Prof Elisa Rossi with valuable contributions by @alexkzis.bsky.social and @ceciledenis.bsky.social from our group!

www.nature.com/articles/s42...

Thrombin cleaves membrane-bound endoglin potentially contributing to the heterogeneity of circulating endoglin in preeclampsia - Communications Biology

Thrombin cleaves membrane-bound endoglin and soluble endoglin, releasing fragments of varying sizes; these findings emphasize the heterogeneity of sEng in preeclampsia, connecting endothelial dysfunct...

www.nature.com

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Alex K @alexkzis.bsky.social · Feb 21

Indeed, it was amazing!!! 😊😊😊😊

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Alex K @alexkzis.bsky.social · Feb 21

👏very nice congress in Lausanne for the #GTH2025. Proud of Jean Solarz, working in our group for 4 years now has PhD student, for his presentation on MICAL1 in platelets. #hemsky #hemesky

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Reposted by Alex K

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Feb 21

Great presention of Caterina Casari during the #GTH2025 on SynthoPlates. When art meets science. 🇨🇭 @caterinacasari.bsky.social #womeninscience #synthoplates

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Reposted by Alex K

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Feb 21

👏An incredible session by 3 incredible women during the #gth2025 with Alessandra Balduini on Red blood cells prod, Catherine Strassel on platelet prod and Caterina Casari with bioinspired platelets. @alessandrabalduini.bsky.social @caterinacasari.bsky.social

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Reposted by Alex K

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Feb 20

The lab is at #GTH2025 in Lausanne with Caterina, Jean and Alex! Jean has already presented his study, but don't miss Caterina tomorrow with the SynthoPlates! @caterinacasari.bsky.social @alexkzis.bsky.social #Science #congress #switzerland

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Reposted by Alex K

Darby Saxbe @darbysaxbe.bsky.social · Feb 4

🚨BREAKING. From a program officer at the National Science Foundation, a list of keywords that can cause a grant to be pulled. I will be sharing screenshots of these keywords along with a decision tree. Please share widely. This is a crisis for academic freedom & science.

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Alex K @alexkzis.bsky.social · Feb 20

Super talk of Stephan Schiffels from Max Planck Institute during the #GTH congress. We are all a mix from our genetic heritage and immigration ! @mpimmg.bsky.social #freedom #immigration
@stschiff.ecoevo.social.ap.brid.gy

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Reposted by Alex K

Société Française de Thrombose et d'Hémostase @sfthemostase.bsky.social · Feb 19

The SFTH is thrilled to support young researchers to attend conferences. We believe in fostering the next generation of researchers. #GTH #u1176 @hithlabinserm1176.bsky.social

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Reposted by Alex K

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Feb 19

Great presentation by PhD student Jean Solarz at #GTH2025 in Lausanne this morning! We are very proud of you!
@alexkzis.bsky.social @hithlabinserm1176.bsky.social

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Alex K @alexkzis.bsky.social · Feb 16

Trail running training of 23km in the Fontainebleau forest and castle! #trail #trailrunning

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Société Française de Thrombose et d'Hémostase @sfthemostase.bsky.social · Feb 9

Join the SFTH 2025 Congress

Now’s your time to shine!

Abstract submissions for the SFTH 2025 Congress are officially open! Don’t miss the chance to showcase your research and innovations to the community.

Submit your work now, here:
www.congres-hemostase.com/abstracts/
Deadline April 25, 2025.

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Alex K @alexkzis.bsky.social · Feb 4

😊 Thk you!!!

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Reposted by Alex K

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Feb 4

Our colleague @alexkzis.bsky.social was invited by #RFTH Hémostase for the annual “best of hemostasis 2024” webtv show with our friends @cedrichermans.bsky.social Annabelle Dupont, Patrick Mismetti & Yves Gruel!

Alex K @alexkzis.bsky.social · Feb 4

Very proud to be invited to the RFHT journal for the Year of hemostasis. Was an amazing experience. #rfht

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Alex K @alexkzis.bsky.social · Feb 4

Very proud to be invited to the RFHT journal for the Year of hemostasis. Was an amazing experience. #rfht

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