Lightnews — Scholar-powered news

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Aug 12

Thrilled to share our latest work in @natcomms.nature.com !
MICAL1 mediates shear-dependent actin remodeling, enabling GPIb-IX-V mechanotransduction and platelet function, and reveals a previously unrecognized role for actin oxidation #mical1 #platelets #cytoskeleton #vwf #gpib

Alex K @alexkzis.bsky.social · Aug 12

Excited to share that our paper is out in @natcomms.nature.com
🔗 rdcu.be/ez3Gt
We uncover how MICAL1 regulates actin dynamics to enhance VWF–GPIbα binding in platelets.

Big thanks to all co-authors & collaborators !
@hithlabinserm1176.bsky.social @echardlab-pasteur.bsky.social

F-actin disassembly by the oxidoreductase MICAL1 promotes mechano-dependent VWF-GPIbα interaction in platelets

Nature Communications - To stop bleeding from an injured vessel, platelets adhere and form a clot despite high shear stress from the flow. Here, the authors show that platelet actin disassembly is...

rdcu.be

1 2

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Jun 21

@isth.org

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Jun 21

@isth.org

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Jun 21

The @hithlabinserm1176.bsky.social is proud to support #ISTHEarlyCareer by leading educational sessions at #ISTH2025!

1 3 2

Reposted by HITh lab InsermU1176

Thomas Reiser @tomreiser.bsky.social · Jun 20

💡Honoring the impact & memory of the late Claire McLintock, this @ISTH.org grant supports #ISTHEarlyCareer innovative research in women's health issues in #thrombosis & #hemostasis.
Learn more ⬇️and apply by ⏳ Sept. 1!
t.co/QYL9cUcoav
Thank you to all donors who supported this grant!
#ISTH2025

8 11

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Jun 21

The @hithlabinserm1176.bsky.social is ready for #ISTH2025!

1 3 2

Reposted by HITh lab InsermU1176

Caterina Casari @caterinacasari.bsky.social · Jun 11

🌟 #ECTH2025 is just around the corner! 🌟
Join us in Prague to explore the latest discoveries in #thrombosisandhaemostasis in a beautiful place rich in culture.
🔗 Register here to secure early bird rates: www.ecth.org/registration/

Curious about CzechFunFact #2?

#ECTH2025 #ECTHJAB #CzechFunFacts

1 2 3

Reposted by HITh lab InsermU1176

Alex K @alexkzis.bsky.social · Jun 5

A special day: Jean Solarz, my first PhD student, successfully defended his thesis. Proud of all the work accomplished! Thks to jury members.

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Jun 5

Huge congratulations to Dr Jean Solarz for brilliantly defending his PhD today! And to his supervisors @alexkzis.bsky.social and Frederic Adam.
We are very proud of you!

A big thank you to all the committee members Prof N Ajzenberg, Dr MP Gratacap, Dr G Romet-Lemonne, Dr Leon, and Dr Ho-Tin-Noe

2 4

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Jun 5

Huge congratulations to Dr Jean Solarz for brilliantly defending his PhD today! And to his supervisors @alexkzis.bsky.social and Frederic Adam.
We are very proud of you!

A big thank you to all the committee members Prof N Ajzenberg, Dr MP Gratacap, Dr G Romet-Lemonne, Dr Leon, and Dr Ho-Tin-Noe

1 4

Reposted by HITh lab InsermU1176

Caterina Casari @caterinacasari.bsky.social · May 28

#ECTH2025 is just around the corner!

Join us to explore the latest discoveries in #thrombosisandhaemostasis in a beautiful place rich in culture and steeped in history!

🔗 Register here to secure early bird rates: www.ecth.org/registration/

#ECTH2025 #ECTHJAB #CzechFunFacts

2 3

Reposted by HITh lab InsermU1176

Caterina Casari @caterinacasari.bsky.social · May 6

#ECTH2025 outstanding lineup of speakers - leaders, innovators, experts in #thrombosis & #haemostasis #ECTH @sophiesusen.bsky.social @cjbinder.bsky.social @cedrichermans.bsky.social

3 2

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · May 2

The lab was present at #WFHCCS2025 in Dubai!
#VWF #VWD #science #WFH
@hithlabinserm1176.bsky.social @caterinacasari.bsky.social

Caterina Casari @caterinacasari.bsky.social · Apr 25

It has been a honor to speak at the #WFHccs2025 in Dubai and share the stage with Drs Michelle Lavin and Augusto Federici!
Thanks #WFH for this opportunity!

2 2

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Apr 5

In search of a #FVIII equivalence for non-factor therapies, we applied in vivo bleeding models 🩸 🐁 . This study suggests that a single FVIII equivalence is unlikely for #emicizumab #SIAmarstacimab and similar molecules.

1 4

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Apr 5

Happy to share our latest work!
Early view on Haematologica Journal
➡️ haematologica.org/article/view...

#nonfactortherapies #FVIII #hemophiliaA #thrombosisandhaemostasis

Early View | Haematologica

haematologica.org

1 3 5

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Apr 4

Important paper from the ISTH SSC Platelet Physiology group! Congrats @alexkzis.bsky.social @dianvanderwaldr.bsky.social and all the authors!
@isth.org @jthjournal.bsky.social
#platelets #thrombosisandhaemostasis

Alex K @alexkzis.bsky.social · Mar 25

We have worked for 2 years with @dianvanderwaldr.bsky.social to propose a protocol for platelet desialylation, and we are excited to now share it. Communication from the ISTH SSC Platelet Physiology. - Journal of Thrombosis and Haemostasis www.jthjournal.org/article/S153... #hemsky #hemesky

Consensus protocol for platelet desialylation (β-galactose exposure) quantification using lectins by flow cytometry: Communication from the ISTH SSC Subcommittee on Platelet Physiology.

Platelets contain many heterogeneous carbohydrates (glycans): often capped by sialic acid. The removal of sialic acid (desialylation) is important for platelet function and clearance, leading to novel...

www.jthjournal.org

1 5 6

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Apr 4

New day, new presentation at #SFH2025
Congrats Jean Solarz-PhD student in our group- for his great presentation!
#platelets #thrombosisandhaemostasis

Alex K @alexkzis.bsky.social · Apr 4

Bravo Jean Solarz for your presentation at the French Society of Hematology on MICAL1 @hithlabinserm1176.bsky.social #sfh #Hemsky #hemesky

1 4

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Apr 4

Congratulations Toscane Viellard -PhD in our group- for her excellent presentation at #SFH2025
#platelets #thrombosisandhaemostasis

1 2

Reposted by HITh lab InsermU1176

Caterina Casari @caterinacasari.bsky.social · Apr 1

If you missed our paper on the humanized murine model of VWD-type 1 (hVWD1) you can read it haematologica.org/article/view...
The model provides a novel platform to test therapeutic options for #VWD one of which is explored in the paper! Thanks Haematologica for the highlight as Editor’s pick!

A fully humanized von Willebrand disease type 1 mouse model as unique platform to investigate novel therapeutic options | Haematologica

haematologica.org

1 3 10

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Mar 27

🎉Huge congratulations to Dr Claire Auditeau 🎓 for brilliantly defending her PhD today! And to her supervisors Pr Delphine Borgel and Dr Francois Saller!
A big thank you to all the committee members Pr Angelillo-Scherrer, Pr Garçon, Dr Allali, Pr Frere!
Happy and proud of your achievement!

2 4

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Mar 27

Happy to share our latest collaborative work on the characterization of the Afro-Caribbean #VWD cohort in Martinique island! Congrats Dr Marie-Daniela Dubois and all the authors!

onlinelibrary.wiley.com/doi/10.1111/...

Clinical, Phenotypic and Genotypic Characteristics of Von Willebrand Disease in Afro‐Caribbeans: Results From a Study in Martinique Island, French West Indies

Background Several cohort studies have investigated the molecular basis of von Willebrand disease (VWD); very few have focused on the Afro-Caribbean population. Objectives To determine the genotyp...

onlinelibrary.wiley.com

1 3

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Mar 21

Our lab is glad to collaborate with both teams! 🥳

Alex K @alexkzis.bsky.social · Mar 19

Great collaboration with Hana Raslova and @alessandrabalduini.bsky.social teams on BSS signaling defect! Recently published. @hithlabinserm1176.bsky.social

haematologica.org/article/view...

Early View | Haematologica

haematologica.org

1 4

Reposted by HITh lab InsermU1176

Caterina Casari @caterinacasari.bsky.social · Mar 6

The JAB is working hard alongside the @ECTH Board to shape a congress that truly supports and empowers #EarlyCareer scientists!

You can already submit your abstract for #ECTH2025 here: www.ecth.org/abstracts/

1 1 4

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Mar 5

Congratulations to our colleague @Dr Jildaz Caroff for successfully obtaining his HDR (Habilitation à diriger des recherches)!! 👏🏻👏🏻👏🏻👏🏻

2 3

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Mar 3

In the @hithlabinserm1176.bsky.social we love to collaborate! Check out this very interesting paper by @Prof Elisa Rossi with valuable contributions by @alexkzis.bsky.social and @ceciledenis.bsky.social from our group!

www.nature.com/articles/s42...

Thrombin cleaves membrane-bound endoglin potentially contributing to the heterogeneity of circulating endoglin in preeclampsia - Communications Biology

Thrombin cleaves membrane-bound endoglin and soluble endoglin, releasing fragments of varying sizes; these findings emphasize the heterogeneity of sEng in preeclampsia, connecting endothelial dysfunct...

www.nature.com

3 5

HITh lab InsermU1176 @hithlabinserm1176.bsky.social · Feb 21

👏An incredible session by 3 incredible women during the #gth2025 with Alessandra Balduini on Red blood cells prod, Catherine Strassel on platelet prod and Caterina Casari with bioinspired platelets. @alessandrabalduini.bsky.social @caterinacasari.bsky.social

4 11