Ali Shariati
@ali-shariati.bsky.social
Assistant Professor of Biomolecular Engineering at UCSC shariatilab.sites.ucsc.edu
Pinned
Ali Shariati
@ali-shariati.bsky.social
· Mar 20
👋 first post here! I’m excited to start by sharing our work on CRISPRa-programmed embryo models! We show that CRISPR activation of 2 elements is sufficient to form an embryo model similar to a natural embryo www.sciencedirect.com/science/arti... @cp-cellstemcell.bsky.social @ucscgenomics.bsky.social
Genomics #postdocs: applications are open for our Next Wave of Faculty in Genomics Symposium (due Jan 15)!. Come share your science in Santa Cruz, home of redwoods, ocean views, and the world’s most unbothered mascot:🐌🌲🌊. Link: genomics.ucsc.edu/calendar_eve... @baskinengineering.bsky.social
December 5, 2025 at 11:02 PM
Genomics #postdocs: applications are open for our Next Wave of Faculty in Genomics Symposium (due Jan 15)!. Come share your science in Santa Cruz, home of redwoods, ocean views, and the world’s most unbothered mascot:🐌🌲🌊. Link: genomics.ucsc.edu/calendar_eve... @baskinengineering.bsky.social
Reposted by Ali Shariati
@alf-castello.bsky.social & I are inviting applications for a competitive PhD studentship to study the mechanisms of translational regulation of the host response to RNA virus infections. The student will be based at Uni. Glasgow. Please spread the word. #RNASky
www.gla.ac.uk/postgraduate...
www.gla.ac.uk/postgraduate...
University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Understanding Pathogens, from Molecules to Phenotypes - Alfredo Castello
www.gla.ac.uk
October 3, 2025 at 11:44 AM
@alf-castello.bsky.social & I are inviting applications for a competitive PhD studentship to study the mechanisms of translational regulation of the host response to RNA virus infections. The student will be based at Uni. Glasgow. Please spread the word. #RNASky
www.gla.ac.uk/postgraduate...
www.gla.ac.uk/postgraduate...
Reposted by Ali Shariati
Together with the Rubin lab @ucsantacruz.bsky.social , we found a surprise: E2F1 drives cells from G0 through the full cell cycle by activating many genes without altering chromatin accessibility! Brilliant work by first author Gerrald Lodewijk, now on the faculty job market,an exceptional scientist
September 26, 2025 at 5:06 AM
Together with the Rubin lab @ucsantacruz.bsky.social , we found a surprise: E2F1 drives cells from G0 through the full cell cycle by activating many genes without altering chromatin accessibility! Brilliant work by first author Gerrald Lodewijk, now on the faculty job market,an exceptional scientist
Reposted by Ali Shariati
Stem Cell Reports welcomes new researchers to its Editorial Board. Their appointments reinforce the Board’s commitment to championing the journal, raising its global visibility, and ensuring rigorous, high-quality peer review. Read more: ow.ly/YicL50X5QJF
October 2, 2025 at 9:32 PM
Stem Cell Reports welcomes new researchers to its Editorial Board. Their appointments reinforce the Board’s commitment to championing the journal, raising its global visibility, and ensuring rigorous, high-quality peer review. Read more: ow.ly/YicL50X5QJF
Together with the Rubin lab @ucsantacruz.bsky.social , we found a surprise: E2F1 drives cells from G0 through the full cell cycle by activating many genes without altering chromatin accessibility! Brilliant work by first author Gerrald Lodewijk, now on the faculty job market,an exceptional scientist
September 26, 2025 at 5:06 AM
Together with the Rubin lab @ucsantacruz.bsky.social , we found a surprise: E2F1 drives cells from G0 through the full cell cycle by activating many genes without altering chromatin accessibility! Brilliant work by first author Gerrald Lodewijk, now on the faculty job market,an exceptional scientist
Reposted by Ali Shariati
Understanding human embryogenesis by building programmable stem cell-based models
Understanding human embryogenesis by building programmable stem cell-based models
Stem cell-based embryo models provide an alternative system to study an elusive period of development. Programmed mouse embryo models have recently been generated by activating two endogenous regulatory elements via epigenome editing. In this forum article, we discuss this achievement along with the potential of translating it to engineering models of human embryogenesis.
dlvr.it
September 3, 2025 at 12:03 PM
Understanding human embryogenesis by building programmable stem cell-based models
In this short article, we share our thoughts on how integrating synthetic biology tools 🛠️ into stem cell–based embryo models can improve their controllability and enhance their capabilities; cell.com/trends/cell-... 🧵1/2
Understanding human embryogenesis by building programmable stem cell-based models
Stem cell-based embryo models provide an alternative system to study an elusive period
of development. Programmed mouse embryo models have recently been generated by activating
two endogenous regulato...
cell.com
September 3, 2025 at 4:43 AM
In this short article, we share our thoughts on how integrating synthetic biology tools 🛠️ into stem cell–based embryo models can improve their controllability and enhance their capabilities; cell.com/trends/cell-... 🧵1/2
Hard to fully celebrate anything these days with so much happening around the world. Still, I’m grateful for the chance to support our stem cell community @isscr.org as a new early career editor @stemcellreports.bsky.social. Looking forward to receiving your stem cell manuscripts! #stemcells
July 3, 2025 at 5:02 PM
Hard to fully celebrate anything these days with so much happening around the world. Still, I’m grateful for the chance to support our stem cell community @isscr.org as a new early career editor @stemcellreports.bsky.social. Looking forward to receiving your stem cell manuscripts! #stemcells
Really grateful to @bernasozen.bsky.social
and @harrymcnamara.bsky.social
for their thoughtful preview of our CRISPRa-programmed embryo model in @cp-cellstemcell.bsky.social. Love the title and the insight. means a lot to us!🙏🏾
and @harrymcnamara.bsky.social
for their thoughtful preview of our CRISPRa-programmed embryo model in @cp-cellstemcell.bsky.social. Love the title and the insight. means a lot to us!🙏🏾
From genes to geometry: Controlling embryo models by programming genomic activation
From genes to geometry: Controlling embryo models by programming genomic activation
Embryo-like models derived from stem cells have emerged as powerful tools to study early development. In this issue, Lodewijk et al. demonstrate that activating just two enhancers via CRISPR activation (CRISPRa) in mouse embryonic stem cells (ESCs) can drive self-organization into structured embryo-like models, offering a genome-driven approach in stem cell and developmental biology.
dlvr.it
June 5, 2025 at 6:20 PM
Really grateful to @bernasozen.bsky.social
and @harrymcnamara.bsky.social
for their thoughtful preview of our CRISPRa-programmed embryo model in @cp-cellstemcell.bsky.social. Love the title and the insight. means a lot to us!🙏🏾
and @harrymcnamara.bsky.social
for their thoughtful preview of our CRISPRa-programmed embryo model in @cp-cellstemcell.bsky.social. Love the title and the insight. means a lot to us!🙏🏾
We wrote this step-by-step method to make it easier for more labs to use CRISPRa to program early embryonic development. Happy to help if you want to start with this or refine your system. Huge thanks to our coauthors and editors link.springer.com/protocol/10.... #stemcells #embryo #crispr
May 31, 2025 at 12:14 AM
We wrote this step-by-step method to make it easier for more labs to use CRISPRa to program early embryonic development. Happy to help if you want to start with this or refine your system. Huge thanks to our coauthors and editors link.springer.com/protocol/10.... #stemcells #embryo #crispr
Reposted by Ali Shariati
[1] Expert in cell segmentation @ali-shariati.bsky.social said that the field of spatial transcriptomics has advanced rapidly in recent years, but accurately defining cell boundaries so that transcripts can be assigned to the correct cell with high precision has remained a key bottleneck.
May 30, 2025 at 9:53 PM
[1] Expert in cell segmentation @ali-shariati.bsky.social said that the field of spatial transcriptomics has advanced rapidly in recent years, but accurately defining cell boundaries so that transcripts can be assigned to the correct cell with high precision has remained a key bottleneck.
Reposted by Ali Shariati
New from Dr. @ali-shariati.bsky.social's lab: Dr. Gerrald Lodewijk and Sayaka Kozuki used #CRISPR activation to enable the self-organization of mouse ESCs into pre-gastrulation embryo models!
📃 @cp-cellstemcell.bsky.social - bit.ly/3QYzW8x
🎙️- bit.ly/3R0KMuB
📃 @cp-cellstemcell.bsky.social - bit.ly/3QYzW8x
🎙️- bit.ly/3R0KMuB
April 7, 2025 at 6:17 PM
New from Dr. @ali-shariati.bsky.social's lab: Dr. Gerrald Lodewijk and Sayaka Kozuki used #CRISPR activation to enable the self-organization of mouse ESCs into pre-gastrulation embryo models!
📃 @cp-cellstemcell.bsky.social - bit.ly/3QYzW8x
🎙️- bit.ly/3R0KMuB
📃 @cp-cellstemcell.bsky.social - bit.ly/3QYzW8x
🎙️- bit.ly/3R0KMuB
Human cells differ in size by ~5 orders of magnitude! Interesting read on how surface to volume ration and diffusion determines limits of a cell's size! www.asimov.press/p/cell-size?... #CellBiology
What Limits a Cell’s Size?
Two physical constraints help explain why cells are so tiny: surface area-to-volume ratios and diffusion. The first article in our new Data Series.
www.asimov.press
March 26, 2025 at 3:29 PM
Human cells differ in size by ~5 orders of magnitude! Interesting read on how surface to volume ration and diffusion determines limits of a cell's size! www.asimov.press/p/cell-size?... #CellBiology
To my 12 followers: please spread the word about this exciting teaching faculty #job opportunity! #AcademicChatter #Facultyjob
The Department of Chemistry & Biochemistry @UCSC
invites applications for an Assistant Teaching Professor. Looking for a dedicated faculty member to bring enthusiasm/excitement to the delivery of undergrad instruction, deadline 5/14/25!
recruit.ucsc.edu/JPF01884
invites applications for an Assistant Teaching Professor. Looking for a dedicated faculty member to bring enthusiasm/excitement to the delivery of undergrad instruction, deadline 5/14/25!
recruit.ucsc.edu/JPF01884
General Chemistry Assistant Teaching Professor (Initial Review Date: May 14, 2025)
University of California, Santa Cruz is hiring. Apply now!
recruit.ucsc.edu
March 25, 2025 at 10:11 PM
To my 12 followers: please spread the word about this exciting teaching faculty #job opportunity! #AcademicChatter #Facultyjob
Reposted by Ali Shariati
Online Now! Lodewijk et al. develop a CRISPRa-programmed embryo model using mouse pluripotent cells. By introducing controllable CRISPR activation tools into pluripotent cells, they enabled the efficient generation of a reproducible model. These tools were also used to disrupt… #stemcells
Self-organization of mouse embryonic stem cells into reproducible pre-gastrulation embryo models via CRISPRa programming
Lodewijk et al. develop a CRISPRa-programmed embryo model using mouse pluripotent cells. By introducing controllable CRISPR activation tools into pluripotent cells, they enabled the efficient generation of a reproducible model. These tools were also used to disrupt developmental pathways, offering a method to study mechanisms of developmental disorders.
dlvr.it
March 21, 2025 at 2:10 PM
Online Now! Lodewijk et al. develop a CRISPRa-programmed embryo model using mouse pluripotent cells. By introducing controllable CRISPR activation tools into pluripotent cells, they enabled the efficient generation of a reproducible model. These tools were also used to disrupt… #stemcells
👋 first post here! I’m excited to start by sharing our work on CRISPRa-programmed embryo models! We show that CRISPR activation of 2 elements is sufficient to form an embryo model similar to a natural embryo www.sciencedirect.com/science/arti... @cp-cellstemcell.bsky.social @ucscgenomics.bsky.social
March 20, 2025 at 10:06 PM
👋 first post here! I’m excited to start by sharing our work on CRISPRa-programmed embryo models! We show that CRISPR activation of 2 elements is sufficient to form an embryo model similar to a natural embryo www.sciencedirect.com/science/arti... @cp-cellstemcell.bsky.social @ucscgenomics.bsky.social