Alex Monell
@amonell.bsky.social
Bioinformatics PhD Student at UC San Diego @GoldrathLab @yeo_lab
Reposted by Alex Monell
📢 Join our team at @alleninstitute.bsky.social! We're hiring a Bioinformatics Scientist II for spatial transcriptomics in immunology.
Our latest work in Nature shows how tissue architecture shapes immune cell diversity. Now we're expanding our team!
Learn more: alleninstitute.org/careers/jobs...
Our latest work in Nature shows how tissue architecture shapes immune cell diversity. Now we're expanding our team!
Learn more: alleninstitute.org/careers/jobs...
Jobs
We are working to solve the biggest mysteries in bioscience.
alleninstitute.org
January 31, 2025 at 7:07 PM
📢 Join our team at @alleninstitute.bsky.social! We're hiring a Bioinformatics Scientist II for spatial transcriptomics in immunology.
Our latest work in Nature shows how tissue architecture shapes immune cell diversity. Now we're expanding our team!
Learn more: alleninstitute.org/careers/jobs...
Our latest work in Nature shows how tissue architecture shapes immune cell diversity. Now we're expanding our team!
Learn more: alleninstitute.org/careers/jobs...
Reposted by Alex Monell
This week @science.org Sarfatis, Moffitt et al. from @bostonchildrens.bsky.social @harvardmed.bsky.social @broadinstitute.org
Highly multiplexed spatial transcriptomics in bacteria | Science www.science.org/doi/10.1126/...
#microsky #microbial #microbiology #genomics
#transcriptomic 🦠🧫
Highly multiplexed spatial transcriptomics in bacteria | Science www.science.org/doi/10.1126/...
#microsky #microbial #microbiology #genomics
#transcriptomic 🦠🧫
Highly multiplexed spatial transcriptomics in bacteria
Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hin...
www.science.org
January 24, 2025 at 4:30 AM
This week @science.org Sarfatis, Moffitt et al. from @bostonchildrens.bsky.social @harvardmed.bsky.social @broadinstitute.org
Highly multiplexed spatial transcriptomics in bacteria | Science www.science.org/doi/10.1126/...
#microsky #microbial #microbiology #genomics
#transcriptomic 🦠🧫
Highly multiplexed spatial transcriptomics in bacteria | Science www.science.org/doi/10.1126/...
#microsky #microbial #microbiology #genomics
#transcriptomic 🦠🧫
Reposted by Alex Monell
New: Amir Ferry, Ananda Goldrath and colleagues @ucsdhealthsci.bsky.social show that differentiation of tissue-resident memory T cells (TRM) is accompanied by the upregulation of the conventional DC1 (cDC1) chemoattractant, Xcl1. https://buff.ly/4hrKCYe
#MucosalImmunology #TumorImmunology
#MucosalImmunology #TumorImmunology
January 22, 2025 at 5:14 PM
New: Amir Ferry, Ananda Goldrath and colleagues @ucsdhealthsci.bsky.social show that differentiation of tissue-resident memory T cells (TRM) is accompanied by the upregulation of the conventional DC1 (cDC1) chemoattractant, Xcl1. https://buff.ly/4hrKCYe
#MucosalImmunology #TumorImmunology
#MucosalImmunology #TumorImmunology
Reposted by Alex Monell
Good to see moscot-tools.org published in @nature.com ! We made existing Optimal Transport (OT) applications in single-cell genomics scalable and multimodal, added a novel spatiotemporal trajectory inference method and found exciting new biology in the pancreas! tinyurl.com/33zuwsep
Mapping cells through time and space with moscot - Nature
Moscot is an optimal transport approach that overcomes current limitations of similar methods to enable multimodal, scalable and consistent single-cell analyses of datasets across spatial and temporal...
tinyurl.com
January 23, 2025 at 8:42 AM
Good to see moscot-tools.org published in @nature.com ! We made existing Optimal Transport (OT) applications in single-cell genomics scalable and multimodal, added a novel spatiotemporal trajectory inference method and found exciting new biology in the pancreas! tinyurl.com/33zuwsep
Reposted by Alex Monell
How do T cells find the proper instructions to navigate tissues? In the Goldrath Lab @ucsdhealthsci.bsky.social, Amir Ferry mapped it out play-by-play. Potentiating these interactions strengthens the immunity cycle and enhances tumor control 1/n
New: Amir Ferry, Ananda Goldrath and colleagues @ucsdhealthsci.bsky.social show that differentiation of tissue-resident memory T cells (TRM) is accompanied by the upregulation of the conventional DC1 (cDC1) chemoattractant, Xcl1. https://buff.ly/4hrKCYe
#MucosalImmunology #TumorImmunology
#MucosalImmunology #TumorImmunology
January 22, 2025 at 6:53 PM
How do T cells find the proper instructions to navigate tissues? In the Goldrath Lab @ucsdhealthsci.bsky.social, Amir Ferry mapped it out play-by-play. Potentiating these interactions strengthens the immunity cycle and enhances tumor control 1/n
Reposted by Alex Monell
It turns out the immune system is playing 4D chess while we thought it was just playing checkers. Using #spatialtranscriptomics from @10xgenomics.bsky.social and @vizgen.bsky.social we were able to peek into the secret lives of tissue resident T cells in the gut as they form after infection 1/n
Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted - Nature
Profiling of the location and transcriptome of tissue-resident memory CD8 T cell formation at single-transcript resolution finds regionalized signalling as the basis of immune diversity in t...
www.nature.com
January 22, 2025 at 5:37 PM
It turns out the immune system is playing 4D chess while we thought it was just playing checkers. Using #spatialtranscriptomics from @10xgenomics.bsky.social and @vizgen.bsky.social we were able to peek into the secret lives of tissue resident T cells in the gut as they form after infection 1/n
Excited that our work went public, Take a look at Max’s thread outlining our research 🧪
@reinacampos.bsky.social @heeg.io
www.nature.com/articles/s41...
@reinacampos.bsky.social @heeg.io
www.nature.com/articles/s41...
January 22, 2025 at 10:18 PM
Excited that our work went public, Take a look at Max’s thread outlining our research 🧪
@reinacampos.bsky.social @heeg.io
www.nature.com/articles/s41...
@reinacampos.bsky.social @heeg.io
www.nature.com/articles/s41...