Amritesh Sarkar
@amritesh-iisc.bsky.social
PhDing @IIScBangalore; affiliated to @SrimontaGayen.
Interests: epigenetics, embryonic development, XCI-XCU, omics
Interests: epigenetics, embryonic development, XCI-XCU, omics
Reposted by Amritesh Sarkar
Stress controls epigenetic inheritance!
A histone ubiquitylation-based regulatory hub links stress/environmental signaling to heterochromatin self-propagation and epigenetic inheritance-reshaping how we think about development, drug resistance, and cancer
👉 nature.com/articles/s41586-025-09899-8
A histone ubiquitylation-based regulatory hub links stress/environmental signaling to heterochromatin self-propagation and epigenetic inheritance-reshaping how we think about development, drug resistance, and cancer
👉 nature.com/articles/s41586-025-09899-8
January 7, 2026 at 4:46 PM
Stress controls epigenetic inheritance!
A histone ubiquitylation-based regulatory hub links stress/environmental signaling to heterochromatin self-propagation and epigenetic inheritance-reshaping how we think about development, drug resistance, and cancer
👉 nature.com/articles/s41586-025-09899-8
A histone ubiquitylation-based regulatory hub links stress/environmental signaling to heterochromatin self-propagation and epigenetic inheritance-reshaping how we think about development, drug resistance, and cancer
👉 nature.com/articles/s41586-025-09899-8
Reposted by Amritesh Sarkar
Epigenetics Update - Single-nucleus multiomics of murine gonads reveals transcriptional regulatory network underlying supporting lineage differentiation bit.ly/4aPlECl
#Epigenetics #SingleCell #Multiomics #Gonads
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Empower your research with high-res epigenetic insights at epigenometech.com
#Epigenetics #SingleCell #Multiomics #Gonads
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Empower your research with high-res epigenetic insights at epigenometech.com
January 7, 2026 at 8:38 AM
Epigenetics Update - Single-nucleus multiomics of murine gonads reveals transcriptional regulatory network underlying supporting lineage differentiation bit.ly/4aPlECl
#Epigenetics #SingleCell #Multiomics #Gonads
---
Empower your research with high-res epigenetic insights at epigenometech.com
#Epigenetics #SingleCell #Multiomics #Gonads
---
Empower your research with high-res epigenetic insights at epigenometech.com
Reposted by Amritesh Sarkar
Extremely excited & proud to share our new preprint - we provide for the first time a single cell map of the mouse brain across sex, the estrous cycle, and peripartum! Data are 🔥 👇
"Single-cell map of the female brain across reproductive transitions"
www.biorxiv.org/content/10.6...
"Single-cell map of the female brain across reproductive transitions"
www.biorxiv.org/content/10.6...
January 4, 2026 at 8:45 PM
Extremely excited & proud to share our new preprint - we provide for the first time a single cell map of the mouse brain across sex, the estrous cycle, and peripartum! Data are 🔥 👇
"Single-cell map of the female brain across reproductive transitions"
www.biorxiv.org/content/10.6...
"Single-cell map of the female brain across reproductive transitions"
www.biorxiv.org/content/10.6...
Reposted by Amritesh Sarkar
Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
Escape from X inactivation is directly modulated by Xist noncoding RNA
Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...
rdcu.be
December 15, 2025 at 4:22 PM
Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
Excited to share my first-ever publication, now out in @stemcellreports.bsky.social !! Heartiest congratulations to
Hemant and @barorunumi.bsky.social for jointly leading the work. Grateful to my PI, Srimonta for giving me this opportunity to contribute to this study.
#m6A #X:A_dosage @isscr.org
Hemant and @barorunumi.bsky.social for jointly leading the work. Grateful to my PI, Srimonta for giving me this opportunity to contribute to this study.
#m6A #X:A_dosage @isscr.org
Delighted to share our publication in @stemcellreports.bsky.social on the role of #m6A_RNA methylation in #Xchromosome dosage compensation during #embryogenesis, jointly driven by Hemant and @barorunumi.bsky.social. 🔗 www.cell.com/stem-cell-re...
@isscr.org
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@isscr.org
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The role of m6A RNA methylation in the maintenance of X chromosome inactivation and X-to-autosome dosage compensation in early embryonic lineages
In this article, Gayen and colleagues demonstrate that m6A RNA methylation is dispensable
for the maintenance of X chromosome inactivation; however, it partly contributes to
the maintenance of X to au...
www.cell.com
December 15, 2025 at 6:56 AM
Excited to share my first-ever publication, now out in @stemcellreports.bsky.social !! Heartiest congratulations to
Hemant and @barorunumi.bsky.social for jointly leading the work. Grateful to my PI, Srimonta for giving me this opportunity to contribute to this study.
#m6A #X:A_dosage @isscr.org
Hemant and @barorunumi.bsky.social for jointly leading the work. Grateful to my PI, Srimonta for giving me this opportunity to contribute to this study.
#m6A #X:A_dosage @isscr.org
Reposted by Amritesh Sarkar
Thrilled to share that @Avinchal from our lab presented her work on effect of heat-humidity stress on fetal development and #epigenetic regulation in the recent #GordonConference on "Epigenetic Variation: Mechanisms and Impact across Systems" #ClimateChange #GlobalWarming #MaternalChildHealth
November 21, 2025 at 12:59 PM
Thrilled to share that @Avinchal from our lab presented her work on effect of heat-humidity stress on fetal development and #epigenetic regulation in the recent #GordonConference on "Epigenetic Variation: Mechanisms and Impact across Systems" #ClimateChange #GlobalWarming #MaternalChildHealth