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andre-head.bsky.social
Andrea Testa
@andre-head.bsky.social
1.1K followers 470 following 12 posts
He/Him | TPD Biotech startup (#2)👷🧬📈 Scientist🔬 Medicinal chemistry⚗️ Chemical biology🧪| musician🎹🎶 | weightlifter 🏋️| 🇮🇹🏴󠁧󠁢󠁳󠁣󠁴󠁿🏳️‍🌈
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andre-head.bsky.social
Andrea Testa @andre-head.bsky.social · Jan 2
Really pleased to share this story from Amphista Therapeutics on the discovery and MoA of a potent and selective BRD9 "targeted glue" degrader. The compound also works in vivo and is orally bioavailable! Fantastic work from the team on a super fun project!
www.biorxiv.org/content/10.1...
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Reposted by Andrea Testa
ritastrack.bsky.social
Rita Strack @ritastrack.bsky.social · Jun 17
Today's Bioorganic bingo 😂
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Reposted by Andrea Testa
lewisgoodall.com
Lewis Goodall @lewisgoodall.com · May 16
In two important ways Labour empowered Nigel Farage and Faragism this week. Both were strategic mistakes. We’ve seen this story before.

New writing from me.

open.substack.com/pub/goodalla...
Labour seems determined to elevate Farage and Faragism- they should stop.
And why Starmer is "better"at foreign policy than domestic
open.substack.com
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andre-head.bsky.social
Andrea Testa @andre-head.bsky.social · Apr 14
Not a bad commute to work.. 🚲
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andre-head.bsky.social
Andrea Testa @andre-head.bsky.social · Mar 18
Nice timing to introduce @trimtech.bsky.social on this platform! Learn more about @trimtech.bsky.social foundational science here:
zkozicka.bsky.social
Zuzanna Kozicka @zkozicka.bsky.social · Mar 18
Very excited for our next seminar this Thursday, March 20th:
Martin Schwalm (@thesgc.bsky.social, formerly Knapp lab) will share insights on UPS inhibitors and Dean Clift (TRIMTECH Tx) will discuss hijacking TRIM21 for protein #degradation!

👉Join us at 12 PM EST/ 5 pm CET (‼️ US/EU time mismatch ‼️)
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andre-head.bsky.social
Andrea Testa @andre-head.bsky.social · Mar 13
Congratulations Rich! 🎉🎉
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Reposted by Andrea Testa
dereklowe.bsky.social
Derek Lowe @dereklowe.bsky.social · Mar 12
The first bifunctional protein degrader to deliver Phase III data! It seems to work, but people were definitely expecting more:
A Bifunctional Degrader Reads Out in Phase 3
www.science.org
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andre-head.bsky.social
Andrea Testa @andre-head.bsky.social · Mar 5
And that's us! The news is out! #TRIMTECH
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andre-head.bsky.social
Andrea Testa @andre-head.bsky.social · Jan 2
Thanks for sharing, Dan!! 🙏
andre-head.bsky.social
Andrea Testa @andre-head.bsky.social · Jan 2
Really pleased to share this story from Amphista Therapeutics on the discovery and MoA of a potent and selective BRD9 "targeted glue" degrader. The compound also works in vivo and is orally bioavailable! Fantastic work from the team on a super fun project!
www.biorxiv.org/content/10.1...
1 10 29
andre-head.bsky.social
Andrea Testa @andre-head.bsky.social · Jan 1
Wishing everyone a happy new year, pushing forward our science, hobbies and passions, surrounded by people we enjoy spending time with!
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andre-head.bsky.social
Andrea Testa @andre-head.bsky.social · Dec 22
Amazing work!! Congratulations @alessiociulli.bsky.social and @alesalerno.bsky.social 💡🥂
alessiociulli.bsky.social
Alessio Ciulli @alessiociulli.bsky.social · Dec 21
🚨 Exciting News! 🚨

What happens when unconventional ideas drive to push boundaries? 🚀 Meet FerroTACs: a novel #PROTAC design using ferrocene as core unit to re-imagining linker design and fine-tune their phys-chem properties. Learn more about our work led by @alesalerno.bsky.social here: 🧪👇 1/5
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Reposted by Andrea Testa
dangrabarczyk.bsky.social
Dan Grabarczyk @dangrabarczyk.bsky.social · Dec 21
Happy to share our UBR4 structures. Check out the preprint to see how this giant E4 ligase complex selects substrates for ubiquitin chain extension. We also look at conservation and adaptations across humans, nematodes and plants.
www.biorxiv.org/content/10.1...
@clausenlab.bsky.social
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andre-head.bsky.social
Andrea Testa @andre-head.bsky.social · Nov 24
Fantastic to see more ternary complex structures of #PROTACs recruiting novel E3 ligases!! www.nature.com/articles/s41...
Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity - Nature Communications
The authors show that DCAF1, a substrate receptor of CUL4 and EDVP E3 ligases, can be recruited by PROTACs to degrade the cancer drug target, WDR5. They also report the crystal structures of PROTAC te...
www.nature.com
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andre-head.bsky.social
Andrea Testa @andre-head.bsky.social · Nov 20
Hi Jordan, can you add me to the list please? Feel like I've degraded BRD4 quite a lot in the last 10 years 🤣
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andre-head.bsky.social
Andrea Testa @andre-head.bsky.social · Nov 15
Randomly meeting friends from #Dundee in Hong Kong airport 🥰🥰🥰
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andre-head.bsky.social
Andrea Testa @andre-head.bsky.social · Nov 15
First post on here, on my way back from a fantastic #TPD conference in Shenzhen, China. Great science and a level of engagement well above expectations! Thanks for having me!!
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