Andreas Horn
@andreashorn.org
Schilling Professor for Computational Neurology at the @netstim.org / University Cologne. Author of @lead-dbs.org & @stimulatingbrains.org
If you are interested in these topics, be sure to also check out the supplementary material which features a massive database with all the data Lauren and Garance compiled. There's certainly data worth for a few more studies and analyses in that dataset.
December 19, 2025 at 10:19 PM
If you are interested in these topics, be sure to also check out the supplementary material which features a massive database with all the data Lauren and Garance compiled. There's certainly data worth for a few more studies and analyses in that dataset.
For CM, localisation effects may be dependent on the form of epilepsy, with stimulation of the parvocellular CM being associated with better outcomes in generalised epilepsy.
December 19, 2025 at 10:19 PM
For CM, localisation effects may be dependent on the form of epilepsy, with stimulation of the parvocellular CM being associated with better outcomes in generalised epilepsy.
What is special about this metaanalysis is that Lauren also compiled stimulation locations across studies.
She shows metaanalytic evidence that in ANT-DBS, proximity of stimulation sites to the mamillothalamic tract is associated with optimal seizure reduction – both on a study and patient level.
She shows metaanalytic evidence that in ANT-DBS, proximity of stimulation sites to the mamillothalamic tract is associated with optimal seizure reduction – both on a study and patient level.
December 19, 2025 at 10:19 PM
What is special about this metaanalysis is that Lauren also compiled stimulation locations across studies.
She shows metaanalytic evidence that in ANT-DBS, proximity of stimulation sites to the mamillothalamic tract is associated with optimal seizure reduction – both on a study and patient level.
She shows metaanalytic evidence that in ANT-DBS, proximity of stimulation sites to the mamillothalamic tract is associated with optimal seizure reduction – both on a study and patient level.
In a massive effort, Lauren compiled evidence from 124 studies, corresponding to 1210 patients and 20 distinct surgical targets – giving an unprecedented overview about how DBS to different targets works for different types of epilepsy.
December 19, 2025 at 10:19 PM
In a massive effort, Lauren compiled evidence from 124 studies, corresponding to 1210 patients and 20 distinct surgical targets – giving an unprecedented overview about how DBS to different targets works for different types of epilepsy.
What is the status of DBS for epilepsy?
Find out in our new review/metaanalysis spearheaded by @laurenahart.bsky.social & Garance Meyer in JNNP: pubmed.ncbi.nlm.nih.gov/40666371/
A 🧵 — please RT for reach! 🙏
Find out in our new review/metaanalysis spearheaded by @laurenahart.bsky.social & Garance Meyer in JNNP: pubmed.ncbi.nlm.nih.gov/40666371/
A 🧵 — please RT for reach! 🙏
December 19, 2025 at 10:19 PM
What is the status of DBS for epilepsy?
Find out in our new review/metaanalysis spearheaded by @laurenahart.bsky.social & Garance Meyer in JNNP: pubmed.ncbi.nlm.nih.gov/40666371/
A 🧵 — please RT for reach! 🙏
Find out in our new review/metaanalysis spearheaded by @laurenahart.bsky.social & Garance Meyer in JNNP: pubmed.ncbi.nlm.nih.gov/40666371/
A 🧵 — please RT for reach! 🙏
Have a wonderful holiday season everyone!
@maikemustin.bsky.social @patriciazvarova.bsky.social Aysu Sahin, Adriana Arrais, Christine Paulus @richarddemann.bsky.social Benjamin Selaskowski, Jan Philipp Payonk @zhongkemei.bsky.social Hannes Heylen
@maikemustin.bsky.social @patriciazvarova.bsky.social Aysu Sahin, Adriana Arrais, Christine Paulus @richarddemann.bsky.social Benjamin Selaskowski, Jan Philipp Payonk @zhongkemei.bsky.social Hannes Heylen
December 17, 2025 at 12:22 PM
Have a wonderful holiday season everyone!
@maikemustin.bsky.social @patriciazvarova.bsky.social Aysu Sahin, Adriana Arrais, Christine Paulus @richarddemann.bsky.social Benjamin Selaskowski, Jan Philipp Payonk @zhongkemei.bsky.social Hannes Heylen
@maikemustin.bsky.social @patriciazvarova.bsky.social Aysu Sahin, Adriana Arrais, Christine Paulus @richarddemann.bsky.social Benjamin Selaskowski, Jan Philipp Payonk @zhongkemei.bsky.social Hannes Heylen
Thank you for the ornamental present from Veerle's & Pablo's neurosurgery lab (Rabea Schmahl ❤️).
December 17, 2025 at 12:22 PM
Thank you for the ornamental present from Veerle's & Pablo's neurosurgery lab (Rabea Schmahl ❤️).
And yes, these Christmas baubles look surprisingly similar to my brain (not my idea..).
December 17, 2025 at 12:22 PM
And yes, these Christmas baubles look surprisingly similar to my brain (not my idea..).
Merry Christmas from the Network Stimulation Institute in Cologne.
And yes, these are DBS electrodes hanging at our Christmas tree.
And yes, these are DBS electrodes hanging at our Christmas tree.
December 17, 2025 at 12:22 PM
Merry Christmas from the Network Stimulation Institute in Cologne.
And yes, these are DBS electrodes hanging at our Christmas tree.
And yes, these are DBS electrodes hanging at our Christmas tree.
See you in Geneva! We have such an incredible line up of speakers this year!
#optoDBS2026 – registration now open at www.optodbs.ch
As last time, we are expanding scope way beyond just DBS and optogenetics – for instance including TMS and LIFU applications this year!
#optoDBS2026 – registration now open at www.optodbs.ch
As last time, we are expanding scope way beyond just DBS and optogenetics – for instance including TMS and LIFU applications this year!
December 15, 2025 at 8:55 PM
See you in Geneva! We have such an incredible line up of speakers this year!
#optoDBS2026 – registration now open at www.optodbs.ch
As last time, we are expanding scope way beyond just DBS and optogenetics – for instance including TMS and LIFU applications this year!
#optoDBS2026 – registration now open at www.optodbs.ch
As last time, we are expanding scope way beyond just DBS and optogenetics – for instance including TMS and LIFU applications this year!
Congratulations to @barbarahollunder.bsky.social for her @natneuro.nature.com paper to be listed in @thetransmitter.bsky.social's 2025 special report on the state of neuroscience among
“The buzziest neuroscience papers of 2023, 2024”
www.thetransmitter.org/community/th...
“The buzziest neuroscience papers of 2023, 2024”
www.thetransmitter.org/community/th...
November 17, 2025 at 8:13 AM
Congratulations to @barbarahollunder.bsky.social for her @natneuro.nature.com paper to be listed in @thetransmitter.bsky.social's 2025 special report on the state of neuroscience among
“The buzziest neuroscience papers of 2023, 2024”
www.thetransmitter.org/community/th...
“The buzziest neuroscience papers of 2023, 2024”
www.thetransmitter.org/community/th...
Effect of sliding a cryosectioned brain slice (almost invisible without polarization filters) into a pair of horizontal filters.
November 6, 2025 at 12:40 PM
Effect of sliding a cryosectioned brain slice (almost invisible without polarization filters) into a pair of horizontal filters.
Truly mesmerizing data – and a true honor to see diese heiligen Hallen!
November 6, 2025 at 12:40 PM
Truly mesmerizing data – and a true honor to see diese heiligen Hallen!
Blown away after visiting INM-1 led by Katrin Amunts this Monday – Markus Axer and her showed us their setup of acquiring whole-brain slices (e.g. 7,000 of them to make up Bigbrain 1) – and the mesmerizing effects of polarized light on cryosectioned (raw) brain sections as can be seen in the video.
November 6, 2025 at 12:40 PM
Blown away after visiting INM-1 led by Katrin Amunts this Monday – Markus Axer and her showed us their setup of acquiring whole-brain slices (e.g. 7,000 of them to make up Bigbrain 1) – and the mesmerizing effects of polarized light on cryosectioned (raw) brain sections as can be seen in the video.
Super happy to have one of the official iconic BigBrain trophies on my desk after giving a keynote at the recent HIBALL summit.
Even though it was a nuisance and led to lots of issues in the BigBrain 1 space, this uniquely skewed brain shape is now iconic and went into the annals of neuroscience.
Even though it was a nuisance and led to lots of issues in the BigBrain 1 space, this uniquely skewed brain shape is now iconic and went into the annals of neuroscience.
November 6, 2025 at 12:28 PM
Super happy to have one of the official iconic BigBrain trophies on my desk after giving a keynote at the recent HIBALL summit.
Even though it was a nuisance and led to lots of issues in the BigBrain 1 space, this uniquely skewed brain shape is now iconic and went into the annals of neuroscience.
Even though it was a nuisance and led to lots of issues in the BigBrain 1 space, this uniquely skewed brain shape is now iconic and went into the annals of neuroscience.
We made the tract openly available in our Lead-DBS software and its association with OCD symptom relief has been confirmed by a series of independent articles (for a review see: www.biologicalpsychiatryjournal.com/article/S000... ).
October 30, 2025 at 10:26 PM
We made the tract openly available in our Lead-DBS software and its association with OCD symptom relief has been confirmed by a series of independent articles (for a review see: www.biologicalpsychiatryjournal.com/article/S000... ).
Originally, the 'OCD response tract' has been defined in a paper by Ningfei Li et al. (www.nature.com/articles/s41...).
October 30, 2025 at 10:26 PM
Originally, the 'OCD response tract' has been defined in a paper by Ningfei Li et al. (www.nature.com/articles/s41...).
A 26-year-old female with refractory OCD who underwent bilateral ALIC DBS. Initial programming yielded limited benefit for OCD symptoms. Reprogramming based on the 'OCD response tract' led to additional symptom relief.
October 30, 2025 at 10:26 PM
A 26-year-old female with refractory OCD who underwent bilateral ALIC DBS. Initial programming yielded limited benefit for OCD symptoms. Reprogramming based on the 'OCD response tract' led to additional symptom relief.
Nice case report led by Ben Shofty's team adding prospective evidence for tract based reprogramming in deep brain stimulation for obsessive compulsive disorder out in @biologicalpsych.bsky.social:
www.biologicalpsychiatryjournal.com/article/S000...
🧵
www.biologicalpsychiatryjournal.com/article/S000...
🧵
October 30, 2025 at 10:26 PM
Nice case report led by Ben Shofty's team adding prospective evidence for tract based reprogramming in deep brain stimulation for obsessive compulsive disorder out in @biologicalpsych.bsky.social:
www.biologicalpsychiatryjournal.com/article/S000...
🧵
www.biologicalpsychiatryjournal.com/article/S000...
🧵
Exciting Sievers lecture by Kamil Uludag ar the HIBALL symposium: what is needed to enable single subject fmri?
W shoutout to main developments w LNM @foxmdphd.bsky.social, functional fingerprinting and digital twins.
W shoutout to main developments w LNM @foxmdphd.bsky.social, functional fingerprinting and digital twins.
October 28, 2025 at 9:02 AM
Exciting Sievers lecture by Kamil Uludag ar the HIBALL symposium: what is needed to enable single subject fmri?
W shoutout to main developments w LNM @foxmdphd.bsky.social, functional fingerprinting and digital twins.
W shoutout to main developments w LNM @foxmdphd.bsky.social, functional fingerprinting and digital twins.
Of course most exciting for me: cytoarchitectonic proof that the VIM exists (and is not a subunit of VL as implied by the Jones nomenclature).
October 28, 2025 at 8:36 AM
Of course most exciting for me: cytoarchitectonic proof that the VIM exists (and is not a subunit of VL as implied by the Jones nomenclature).
Truly awe-inspiring updates around BigBrain given by Katrin Amunts at the HIBALL closing symposium in Berlin today.
October 28, 2025 at 8:24 AM
Truly awe-inspiring updates around BigBrain given by Katrin Amunts at the HIBALL closing symposium in Berlin today.
Ghostwriting of the finest sense.
October 3, 2025 at 7:11 AM
Ghostwriting of the finest sense.