Paper here: pubmed.ncbi.nlm.nih.gov/40666371/
Please RT for reach! 🙏

If you are interested in these topics, be sure to also check out the supplementary material which features a massive database with all the data Lauren and Garance compiled. There's certainly data worth for a few more studies and analyses in that dataset.

For CM, localisation effects may be dependent on the form of epilepsy, with stimulation of the parvocellular CM being associated with better outcomes in generalised epilepsy.

What is special about this metaanalysis is that Lauren also compiled stimulation locations across studies.
She shows metaanalytic evidence that in ANT-DBS, proximity of stimulation sites to the mamillothalamic tract is associated with optimal seizure reduction – both on a study and patient level.

In a massive effort, Lauren compiled evidence from 124 studies, corresponding to 1210 patients and 20 distinct surgical targets – giving an unprecedented overview about how DBS to different targets works for different types of epilepsy.

Have a wonderful holiday season everyone!

@maikemustin.bsky.social @patriciazvarova.bsky.social Aysu Sahin, Adriana Arrais, Christine Paulus @richarddemann.bsky.social Benjamin Selaskowski, Jan Philipp Payonk @zhongkemei.bsky.social Hannes Heylen

Thank you for the ornamental present from Veerle's & Pablo's neurosurgery lab (Rabea Schmahl ❤️).

And yes, these Christmas baubles look surprisingly similar to my brain (not my idea..).

Robert Chen, Elisa Konofagou, Yihua Ning, Emilie Mace, Daniel Razansky, Lennart Verhagen, Shan Siddiqi, Andreas Vlachos, Hartwig Siebner, Indrit Bègue, Jonathan Downar, Minmin Luo – and of course Christian Lüscher!

Eric Yttri, Wolf-Julian Neumann, Simon Little, Edouardo Moraud, John Eraifej, Carine Karachi, Brian Lau, Meaghan Creed, Alan Mardinly, Jerome Lecoq, Philippe Domenech, Tifei Yuan, Jean-Francois Aubry, Charlotte Luff