Lightnews — Scholar-powered news

Reposted by Andrew Grotzinger

Institute for Behavioral Genetics (IBG) @ibg.colorado.edu · 9d

University of Colorado Boulder Department of Psychology & Neuroscience is searching for TWO tenure track assistant professors. This is open to all department areas, including Behavioral, Psychiatric, and Statistical Genetics🧬 jobs.colorado.edu/jobs/JobDeta...

Assistant Professor

jobs.colorado.edu

1 7 6

Reposted by Andrew Grotzinger

Tiffany Ito @tiffanyito.bsky.social · 16d

University of Colorado Boulder Psychology & Neuroscience is searching for TWO tenure track assistant professors!!

jobs.colorado.edu/jobs/JobDeta...

#socialpsychology #cogpsyc #PsychSciSky #PsychJob
#psycjobs #psychology

1/n

Assistant Professor

jobs.colorado.edu

4 110 110

Andrew Grotzinger @andrewgrotzinger.bsky.social · Aug 6

Amazing work from my colleague and postdoc Dr. Isabelle Foote on the genetic architecture of frailty. Encourage you to check it out!!!!

Institute for Behavioral Genetics (IBG) @ibg.colorado.edu · Aug 6

New work in Nature Genetics from IBG members lead by @isyfoote.bsky.social (along with @andrewgrotzinger.bsky.social) examining different measures of frailty using Genomic SEM. Findings reveal six genomic factors with unique biological pathways and clinical correlates. www.nature.com/articles/s41...

Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling - Nature Genetics

Multivariate genome-wide association analyses of the latent genetic architecture of frailty identify one general factor of genetic overlap across all frailty deficits and six factors indexing a shared...

www.nature.com

4 14

Reposted by Andrew Grotzinger

The Polygenic Score Catalog @pgscatalog.bsky.social · Aug 6

Some recent data:

- First scores for frailty measurements (@isyfoote.bsky.social & @andrewgrotzinger.bsky.social‬): www.pgscatalog.org/publication/...
- Comprehensive comparison of type 2 diabetes PGS in Qatari Biobank: www.pgscatalog.org/publication/...

Share PGS 👉 www.PGSCatalog.org/submit!

PGS Catalog - Foote IF, Nat Genet (2025) (Publication)

The Polygenic Score (PGS) Catalog is an open database of published PGS and the relevant metadata needed to apply and evaluate them correctly.

www.pgscatalog.org

3 9

Reposted by Andrew Grotzinger

Institute for Behavioral Genetics (IBG) @ibg.colorado.edu · Jul 21

Check out this new work from IBG graduate student @breunigsophie.bsky.social that applies Genomic SEM to examine the relationship between genomic factors for immune-mediated diseases and psychiatric disorders. www.nature.com/articles/s41...

Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders - Translational Psychiatry

Translational Psychiatry - Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders

www.nature.com

4 9

Andrew Grotzinger @andrewgrotzinger.bsky.social · May 22

The title on 2 😱 you're in too deep Perline 🤣

1 3

Reposted by Andrew Grotzinger

Ted Schwaba @tedmond.bsky.social · May 20

Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...

5 71 160

Andrew Grotzinger @andrewgrotzinger.bsky.social · May 16

I'm not 100% sure, but think if you have the data already downloaded you can run local analyses. Otherwise my sense if you have to analyze on RAP.

1

Reposted by Andrew Grotzinger

Ted Schwaba @tedmond.bsky.social · Mar 7

Out today, our method for comparing multivariate genetic architecture across groups of people, called Genomic Structural Invariance: www.nature.com/articles/s41...

(feat: @tuckerdrob.bsky.social @michelnivard.bsky.social @andrewgrotzinger.bsky.social @mijke.bsky.social @jorsmo.bsky.social et al.)

Comparison of the multivariate genetic architecture of eight major psychiatric disorders across sex - Nature Genetics

Genomic structural invariance, an extension of genomic structural equation modeling, identifies similarities and differences between males and females in the genetic architectures of eight psychiatric...

www.nature.com

1 20 48

Andrew Grotzinger @andrewgrotzinger.bsky.social · Jan 28

One of my talented graduate students (@breunigsophie.bsky.social) is putting together an immune-psychiatric focused symposium submission for the Behavior Genetics Association 2025 meeting in Atlanta. She needs one more talk to fill the symposium; if interested send me a message!

1 2 5

Andrew Grotzinger @andrewgrotzinger.bsky.social · Dec 6

GNA estimates conditional genetic associations across traits, SNPs, or genes. In an empirical application, we show that a GWAS of Type 2 Diabetes implicates broad pathways (e.g. chemical reactions in the body) whereas SNP-level GNA results pinpoint core disease processes (e.g. insulin secretion) 2/2

Genomic network analysis characterizes genetic architecture and identifies trait-specific biology

Pervasive genetic overlap across human complex traits necessitates developing multivariate methods that can parse pleiotropic and trait-specific genetic signals. Here, we introduce Genomic Network Ana...

www.medrxiv.org

2

Andrew Grotzinger @andrewgrotzinger.bsky.social · Dec 6

You've heard of DNA, but what about GNA? Very excited about this preprint with @jgthorp.bsky.social and others that introduces Genomic Network Analysis (GNA), an open-source multivariate tool for performing network analysis using GWAS summary statistics as input. 1/2
www.medrxiv.org/content/10.1...

Genomic network analysis characterizes genetic architecture and identifies trait-specific biology

Pervasive genetic overlap across human complex traits necessitates developing multivariate methods that can parse pleiotropic and trait-specific genetic signals. Here, we introduce Genomic Network Ana...

www.medrxiv.org

4 10 29

Reposted by Andrew Grotzinger

Jackson Thorp @jgthorp.bsky.social · Dec 6

New preprint! www.medrxiv.org/content/10.1...
We introduce Genomic Network Analysis (GNA), a method to conduct network analysis on GWAS sumstats / estimate conditional genetic associations at multiple levels of analysis.
@andrewgrotzinger.bsky.social @zaccyg.bsky.social @drwilliamreay.bsky.social

Genomic network analysis characterizes genetic architecture and identifies trait-specific biology

Pervasive genetic overlap across human complex traits necessitates developing multivariate methods that can parse pleiotropic and trait-specific genetic signals. Here, we introduce Genomic Network Ana...

www.medrxiv.org

2 15

Reposted by Andrew Grotzinger

Sarah Harris @saraheharris99.bsky.social · Dec 2

Exciting post-doc position available working on my NIH funded project "Longitudinal multi-omic biomarkers for neurocognitive decline prior to dementia onset". Based in the beautiful city of Edinburgh within @edinunilbc.bsky.social elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Postdoctoral Research Associate

The Lothian Birth Cohorts Group within the Psychology Department, School of Philosophy, Psychology and Language Sciences is seeking a PDRA on a full time, fixed term contract until 30th of June 2025 i...

elxw.fa.em3.oraclecloud.com

6 8

Reposted by Andrew Grotzinger

Abdel Abdellaoui @dr-appie.bsky.social · Oct 4

If you're not following the Behavior Genetics Association account yet (@behaviorgenetic.bsky.social), please do! 🧬🧠🤸🏽

Me and Margot van de Weijer will be running it for the time being, sharing BGA updates and summaries of interesting research from their classic journal 📜

RTs appreciated! 🙏🏽

7 12

Andrew Grotzinger @andrewgrotzinger.bsky.social · Sep 26

My take would be that start values are conceptually the closest to what you are describing. Most softwares allow for specifying this in some fashion. This tells the SEM software to start by trying out the suggested values and then expands the search space from there.

1 2

Andrew Grotzinger @andrewgrotzinger.bsky.social · Sep 23

Here's a picture of my current lab (graduate students Luke Schaffer, Jeremy Lawrence, Sophie Breunig and my postdoc Dr. Isy Foote). We are a collaborative, productive, and nice group and I hope you'll consider joining us!

4

Andrew Grotzinger @andrewgrotzinger.bsky.social · Sep 23

Students in my lab have an interest in at least one of the research areas listed above, but are not required to engage in research in all areas. Information on how to apply can be found here. Due date for applications is November 15th.
www.colorado.edu/psych-neuro/...

Faculty Recruiting Graduate Students

Recruitment Plans for Fall 2025 Prospective grad

www.colorado.edu

1 1

Andrew Grotzinger @andrewgrotzinger.bsky.social · Sep 23

🚨Writing to say that I am actively recruiting PhD students in the clinical -or- behavioral, psychiatric, and statistical genetics program (BPSG) at CU Boulder for a Fall 2025 start date. My lab focuses on genomic methods development and applications to psychiatric and aging outcomes (e.g., dementia)

1 11 12

Reposted by Andrew Grotzinger

medRxivpreprint @medrxivpreprint.bsky.social · Jul 19

Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders https://www.medrxiv.org/content/10.1101/2024.07.18.24310651v1

Importance: Autoimmune and autoinflammatory diseases have been linked to psychiatric disorders in th

www.medrxiv.org

3 3

Reposted by Andrew Grotzinger

Sophie Breunig @breunigsophie.bsky.social · Aug 15

New preprint just dropped! 🧬🦠
For this project, we looked at the genetic relationships between psychiatric disorders and immune-mediated diseases.

Check out the full paper here: www.medrxiv.org/content/10.1...

Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders

medRxiv - The Preprint Server for Health Sciences

www.medrxiv.org

6 2 7

Andrew Grotzinger @andrewgrotzinger.bsky.social · Aug 7

4. One more! Preprint from graduate student Jeremy Lawrence that looks at the links between a wide-range of physical and psychiatric disorders. Findings include that substance use disorders, MDD, and ADHD are as associated with medical traits as with psychiatric. www.medrxiv.org/content/10.1...

Shared Genetic Liability across Systems of Psychiatric and Physical Illness

medRxiv - The Preprint Server for Health Sciences

www.medrxiv.org

Andrew Grotzinger @andrewgrotzinger.bsky.social · Jul 25

3. IBG graduate student Luke Schaffer investigated the genetic signal in autism spectrum disorder (ASD) that is unique of ADHD. Findings reveal clinical correlates, genes, and biological pathways unique to ASD: www.ncbi.nlm.nih.gov/pmc/articles...

Characterizing Genetic Pathways Unique to Autism Spectrum Disorder at Multiple Levels of Biological Analysis

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by atypical patterns of social functioning and repetitive/restricted behaviors. ASD commonly co-occurs with ADHD and, des...

www.ncbi.nlm.nih.gov

1 3

Andrew Grotzinger @andrewgrotzinger.bsky.social · Jul 25

2. IBG graduate student Sophie Breunig examined genetic links between immune-mediated and psychiatric factors. Findings reveal unique psychiatric links for factors defined by autoimmune vs autoinflammatory diseases: www.medrxiv.org/content/10.1...

Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders

medRxiv - The Preprint Server for Health Sciences

www.medrxiv.org

1 3

Andrew Grotzinger @andrewgrotzinger.bsky.social · Jul 25

Proud mentor moment! Three preprints recently released from the lab:
1. Postdoc Dr. Isy Foote examined the genetic architecture of frailty. Analyses reveal seven factors of frailty with unique genetic associations, clinical correlates, and biological pathways: www.medrxiv.org/content/10.1...

Uncovering the multivariate genetic architecture of frailty with genomic structural equation modelling

medRxiv - The Preprint Server for Health Sciences

www.medrxiv.org

1 1 11