Lightnews — Scholar-powered news

The Polygenic Score Catalog @pgscatalog.bsky.social · Aug 6

Some recent data:

- First scores for frailty measurements (@isyfoote.bsky.social & @andrewgrotzinger.bsky.social‬): www.pgscatalog.org/publication/...
- Comprehensive comparison of type 2 diabetes PGS in Qatari Biobank: www.pgscatalog.org/publication/...

Share PGS 👉 www.PGSCatalog.org/submit!

PGS Catalog - Foote IF, Nat Genet (2025) (Publication)

The Polygenic Score (PGS) Catalog is an open database of published PGS and the relevant metadata needed to apply and evaluate them correctly.

www.pgscatalog.org

3 9

The Polygenic Score Catalog @pgscatalog.bsky.social · Jul 24

Check out the latest and most powerful polygenic scores for body mass index and obesity from @roelofajsmit.bsky.social et al. in the PGS Catalog: www.pgscatalog.org/publication/.... Thanks to the authors for submitting the data pre-publication! Submission information @ www.pgscatalog.org/submit

1

The Polygenic Score Catalog @pgscatalog.bsky.social · Jul 22

At #ISMB2025 in Liverpool? Interested in polygenic scores? Ben Wingfield will be back at his poster this afternoon at 4 PM (B507 / TransMed) to discuss all things pgsc_calc - our portable, scalable Nextflow workflow, designed for PGS calculation at scale in TREs! Go say hello!

1 3

The Polygenic Score Catalog @pgscatalog.bsky.social · Jun 17

Check out this PRS (www.pgscatalog.org/publication/...) and more in the latest PGS Catalog data release! Thanks to @pnatarajanmd.bsky.social & co for submitting their scores! See www.pgscatalog.org/submit for information about how to share your work!

2 3

The Polygenic Score Catalog @pgscatalog.bsky.social · May 26

Great to see so many PGS Catalog IDs in the wild on posters at #ESHG2025, #OpenData and #FAIRdata for all! Users and submitters are the lifeblood of the resource, get in touch if you ever have feedback or suggestions for improvement!

1 5

Reposted by The Polygenic Score Catalog

Sam Lambert @iamslambert.bsky.social · May 23

Great fun sharing the @pgscatalog.bsky.social at the pre- #ESHG25 course on open-source genomics resources. Thanks to Juliana Cerqueira and Inga Prokopenko for the invite!

Looking forward to the rest of the conference!

2 6

The Polygenic Score Catalog @pgscatalog.bsky.social · May 20

Interested in the results of the BARCODE PRS-guided prostate cancer screening study last month in @nejm.org? Just added to the Catalog is the PRS that was used in the cohort: www.pgscatalog.org/score/PGS005.... This and more in the latest release!

8 12

Reposted by The Polygenic Score Catalog

Andrea Ganna @andganna.bsky.social · Apr 28

🚨 EBI has just lunched a new portal to calculate genetic scores from individual-level genetic data.

Check it out 👇. It is very cool!

geneticscores.org

It is linked with the @pgscatalog.bsky.social

This was supported by INTERVENE

GeneticScores.org

GeneticScores.org provides tools and data to help AI developers and human health researchers make better polygenic scores

geneticscores.org

10 12

The Polygenic Score Catalog @pgscatalog.bsky.social · Apr 17

Another highlight from this release is a new score for all-cause dementia, 🔗: www.pgscatalog.org/score/PGS005.... Thanks to D'Aoust et al. for sharing!

Mike Inouye @mikeinouye.bsky.social · Mar 5

A polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

1 7

The Polygenic Score Catalog @pgscatalog.bsky.social · Apr 17

Thanks to @mglevin.bsky.social for sharing this new heart failure PRS from @naturegenet.bsky.social, 🔗: www.pgscatalog.org/score/PGS005.... This and more in the latest release, submit your scores at www.pgscatalog.org/submit!

1 3 10

Reposted by The Polygenic Score Catalog

Sam Lambert @iamslambert.bsky.social · Apr 1

Interested in calculating polygenic scores in the All Of Us workbench? Like those from @pgscatalog.bsky.social? Take a look at our new documentation for how to run pgsc_calc in the cloud environment: pgsc-calc.readthedocs.io/en/latest/ho.... Very much work-in-progress, optimisations incoming!

Running the PGS Catalog Calculator via the All of Us workbench — Polygenic Score (PGS) Catalog Calculator documentation

pgsc-calc.readthedocs.io

1 10 24

The Polygenic Score Catalog @pgscatalog.bsky.social · Mar 31

Discover data from our latest release:
- New PGS for atrial fibrillation (buff.ly/E1TkmKv)
- PGS optimised for East Asian ancestry in cancer (buff.ly/gLkYKVo) and 10 other common diseases (buff.ly/nG7rOIq)

Find out how to submit your data here: buff.ly/nJCjUMr

2 3

Reposted by The Polygenic Score Catalog

EMBL-EBI Training @training.ebi.embl.org · Mar 11

We're pleased to announce our latest free online tutorial! This is for anyone who wants to find out more about polygenic scores and how to explore the data in the PGS Catalog: www.ebi.ac.uk/training/onl...

Produced in collaboration with @pgscatalog.bsky.social

Online tutorial
Polygenic scores and the PGS Catalog
Predicting genetic risks and traits
Access anytime, anywhere

3 9

The Polygenic Score Catalog @pgscatalog.bsky.social · Mar 4

📣 Excited to share our new tutorial with @training.ebi.embl.org ! The course covers the basics of polygenic scores and describes the PGS Catalog resources (buff.ly/L8e6a3J, including pgsc_calc), a great overview of the area. Access the course online at buff.ly/CEBWMio!

11 25

The Polygenic Score Catalog @pgscatalog.bsky.social · Feb 26

Also out today is this multi-ancestry PGS for PSA! 🔗: www.pgscatalog.org/publication/...

Linda Kachuri @lindakachuri.bsky.social · Feb 11

📣 Happy to share our latest paper - an exciting step forward for PSA genetics with a much larger and more diverse GWAS and a more predictive PGS ⚡️

@johnwitte.bsky.social
@stanford-cancer.bsky.social
@stanfordmedicine.bsky.social

Nature Genetics @natgenet.nature.com · Feb 11

📢ONLINE @naturegenet.bsky.social

📰Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups.

By Thomas Hoffmann, @lindakachuri.bsky.social, @johnwitte.bsky.social and co.

⬇️

www.nature.com/articles/s41...

3 6

The Polygenic Score Catalog @pgscatalog.bsky.social · Feb 26

Now available in the PGS Catalog 🔗: www.pgscatalog.org/publication/...! Thanks to authors like Sean for submitting the data directly, find out how to submit your data at pgscatalog.org/submit

1 3 7

The Polygenic Score Catalog @pgscatalog.bsky.social · Feb 6

Welcome @omicspred.bsky.social (www.omicspred.org) to 🦋! OmicsPred focuses on curating genetic scores for omics-traits (genes, proteins, metabolites) to power large-scale association analyses. Check it out!

1 9

Reposted by The Polygenic Score Catalog

GWAS Catalog @gwascatalog.bsky.social · Jan 20

Are you going to #FOG2025? Meet us to learn about the integration of processes with PGSCatalog or metadata generation and harmonisation pipelines for #SumStats. Share your data bit.ly/38rNSjx #openaccess

3 8

Reposted by The Polygenic Score Catalog

The Polygenic Score Catalog @pgscatalog.bsky.social · Nov 26

Let's start with introductions! The PGS Catalog is an open database of polygenic scores and the relevant metadata required for accurate application and evaluation. Everything is on our website www.PGSCatalog.org, and our newest publication describes how far we've come: rdcu.be/d1vTG since 2019!

Gif of Julie Andrews singing "Let's start at the very beginning" from Sound of Music.

1 12 15

The Polygenic Score Catalog @pgscatalog.bsky.social · Nov 27

If you're interested in the PGS Catalog Calculator we're hosting a free training webinar @ebi.embl.org on December 4th: www.ebi.ac.uk/training/eve... (registration required). Come along, or catch up with the recording after!

cc @iamslambert.bsky.social

8 10

The Polygenic Score Catalog @pgscatalog.bsky.social · Nov 26

The Catalog isn't just a knowledgebase and source of polygenic scores, we also provide open-soruce tools to make PGS calculation easier and more reproducible! You can find our pgsc_calc tool on github (github.com/PGScatalog/p...) with extensive documentation (pgsc-calc.readthedocs.io/en/latest/).

1 6 12

The Polygenic Score Catalog @pgscatalog.bsky.social · Nov 26

Let's start with introductions! The PGS Catalog is an open database of polygenic scores and the relevant metadata required for accurate application and evaluation. Everything is on our website www.PGSCatalog.org, and our newest publication describes how far we've come: rdcu.be/d1vTG since 2019!

1 12 15