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Reposted by Sam Lambert

Mike Inouye @mikeinouye.bsky.social · 3d

ICYMI 👉 Quantifying the fairness of polygenic risk scores: our modelling and analysis for CVD risk prediction www.medrxiv.org/content/10.1...

Overall PRS fairness levels similar to or better than traditional predictors (age, sex, BP, lipids)

h\t @iamslambert.bsky.social @clairecoffey.bsky.social

Current polygenic risk scores are unlikely to exacerbate unfairness in cardiovascular disease risk prediction

Background Current cardiovascular disease (CVD) risk prediction models place many individuals in an intermediate risk category where clinical decision-making remains uncertain, highlighting a critical...

www.medrxiv.org

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Reposted by Sam Lambert

Emil Uffelmann @euffelmann.bsky.social · 12d

Our new paper is out, in which we developed an approach to transform Polygenic Scores (PGSs) into disorder probabilities (i.e., the absolute lifetime disorder risk).

Below a thread 👇

open access link: rdcu.be/eIjvC

Estimating disorder probability based on polygenic prediction using the BPC approach

Nature Communications - Here the authors present a method to transform polygenic scores into disorder probabilities using only GWAS summary statistics, genotype data and a prior - no tuning sample...

rdcu.be

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Reposted by Sam Lambert

Sam Lambert @iamslambert.bsky.social · 19d

Algorithmic fairness metrics have made big inroads in the AI/ML fields to investigate model bias. A clever PhD student (@clairecoffey.bsky.social) thought, why don't you see these methods applied to CVD risk prediction or polygenic risk scores? Enter our new preprint: www.medrxiv.org/content/10.1...

Current polygenic risk scores are unlikely to exacerbate unfairness in cardiovascular disease risk prediction

Background: Current cardiovascular disease (CVD) risk prediction models place many individuals in an intermediate risk category where clinical decision-making remains uncertain, highlighting a…

www.medrxiv.org

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Sam Lambert @iamslambert.bsky.social · 19d

On a personal note, it's great to have the first preprint out from my first PhD student! bsky.app/profile/clai...

Claire Coffey @clairecoffey.bsky.social · Mar 10

I passed my PhD viva! 🎉 Thank you to everyone who has been a part of this incredible journey, especially my supervisors @iamslambert.bsky.social, Angela Wood, and @mikeinouye.bsky.social 😄

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Sam Lambert @iamslambert.bsky.social · 19d

There's much more in the preprint - a great team effort from @clairecoffey.bsky.social @sritchie73.bsky.social, Lisa Pennells, Angela Wood & @mikeinouye.bsky.social all from @cambridge-ceu.bsky.social!

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Sam Lambert @iamslambert.bsky.social · 19d

Clinical statements (AHA, ESC) have suggested that PRS may be most useful as a risk-enhancing factor for those at intermediate risk. We used PRS to reclassify individuals at intermediate risk by QRISK3 and showed improved sensitivity and fairness benefits (particularly for age & sex).

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Sam Lambert @iamslambert.bsky.social · 19d

We evaluated PRS in two contexts, as a standalone risk predictor and as a risk-enhancing factor. Given the known performance differences across ancestries, we were surprised to find that the fairness of PRS predictions across ethnicities was equal to or lower other CVD risk factors when used alone.

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Sam Lambert @iamslambert.bsky.social · 19d

Algorithmic fairness metrics have made big inroads in the AI/ML fields to investigate model bias. A clever PhD student (@clairecoffey.bsky.social) thought, why don't you see these methods applied to CVD risk prediction or polygenic risk scores? Enter our new preprint: www.medrxiv.org/content/10.1...

Current polygenic risk scores are unlikely to exacerbate unfairness in cardiovascular disease risk prediction

Background: Current cardiovascular disease (CVD) risk prediction models place many individuals in an intermediate risk category where clinical decision-making remains uncertain, highlighting a…

www.medrxiv.org

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Reposted by Sam Lambert

Mike Inouye @mikeinouye.bsky.social · 19d

Awesome work by @clairecoffey.bsky.social @iamslambert.bsky.social @sritchie73.bsky.social Lisa Pennells and Angela Wood

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Reposted by Sam Lambert

Mike Inouye @mikeinouye.bsky.social · 19d

PRS are well know to have variable performance across ancestries, frequently with a European bias. We looked closely at fairness of PRS for CVD risk prediction, both with PRS on it's own and in an integrated risk score...

Our results were surprising... 👉 www.medrxiv.org/content/10.1...

Current polygenic risk scores are unlikely to exacerbate unfairness in cardiovascular disease risk prediction

Background: Current cardiovascular disease (CVD) risk prediction models place many individuals in an intermediate risk category where clinical decision-making remains uncertain, highlighting a critica...

www.medrxiv.org

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Reposted by Sam Lambert

BHF Cardiovascular Epidemiology Unit at Cambridge @cambridge-ceu.bsky.social · 19d

🚨Exciting fully funded PhD opportunity!

Applications are open for a DTP iCase interdisciplinary PhD studentship in Public Health and Primary Care supervised by @eliasallara.bsky.social

Apply by 2 Dec 2025 👉 www.cam.ac.uk/jobs/dtp-ica...

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Reposted by Sam Lambert

Mike Inouye @mikeinouye.bsky.social · Aug 27

Sept is approaching & I can already hear initial chats/enquiries for potential PhD studies happening!

If you're interested in a PhD, check out our department @cam.ac.uk www.phpc.cam.ac.uk/education-an...

We've a super interdisciplinary faculty spanning primary care, data science, epidemiology etc

Doctoral Training | Department of Public Health and Primary Care (PHPC)

Course Code – MDPU22 A doctorate from the University of Cambridge is primarily a research degree based on a research programme developed in conjunction with a supervisor.

www.phpc.cam.ac.uk

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Reposted by Sam Lambert

Loïc Lannelongue @loiclnlg.bsky.social · 23d

⏰ Last couple of days to apply to join my group @Cambridge as a postdoc and work on the environmental (un)sustainability of AI!

⏳ Closing September 16th.

✏️ Apply here: tinyurl.com/2ukkp8yx

Or learn more about what we do at www.lannelongue-group.org

Initial examples of research projects below 👇

Research Associate*/Research Assistant in Sustainability of AI (Fixed Term)

An exciting opportunity has arisen for a talented researcher to join our team as part of the Green Algorithms Initiative, one of the leading academic teams in the field of sustainable computing. The

www.cam.ac.uk

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Reposted by Sam Lambert

Mike Inouye @mikeinouye.bsky.social · Aug 3

ICYMI it's not a Max Planck directorship but still a great opportunity to join an exciting research environment down under 😁 bsky.app/profile/mike...

Mike Inouye @mikeinouye.bsky.social · Jul 25

📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791...

You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁

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Reposted by Sam Lambert

Mike Inouye @mikeinouye.bsky.social · Jul 25

📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791...

You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁

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Reposted by Sam Lambert

Chris Wallace @chr1sw.bsky.social · Jul 2

Is anyone aware of PhD students having access to #allofus data? We are being told it's impossible. Which seems... impractical... given that students do so much of the research in many places. Please reskeet even if you don't know the answer? Would really like to resolve this barrier for my student.

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Sam Lambert @iamslambert.bsky.social · Jul 1

Interested in methods for updating risk prediction models (time-to-event) with new features? Check out this new paper with Will Underwood & co introducing the CARE method, and an application where we augment SCORE2 with PGS & IMD: arxiv.org/abs/2506.23870.

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Reposted by Sam Lambert

OmicsPred @omicspred.bsky.social · Jun 16

We're working closely with our PredictDB colleagues to bring you an integrated resource for multi-omic predictors

We're happy to announce that PrediXcan GTExV8 expression predictors are now annotated and openly available via OmicsPred! www.omicspred.org

More info www.omicspred.org/publication/...

OmicsPred is an atlas of genetic scores for prediction of multi-omics data.

www.omicspred.org

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Reposted by Sam Lambert

Mike Inouye @mikeinouye.bsky.social · Jun 16

Super excited to see beginning integration of PredictDB into OmicsPred!

We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org

More on its way... a wonderful collab with @hakyim.bsky.social & co!

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Reposted by Sam Lambert

Mike Inouye @mikeinouye.bsky.social · Jun 12

❓Has anyone looked at the overlap between MVP and All of Us? Big enough to worry about when training/testing PGS?

cc @sritchie73.bsky.social @iamslambert.bsky.social

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Reposted by Sam Lambert

Mike Inouye @mikeinouye.bsky.social · May 29

NB: The Polygenic Score Catalog has just lost its NIH funding. It was substantial. We are now on auxillary funding sources.

If anyone has a spare £1m plz DM

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Reposted by Sam Lambert

Mike Inouye @mikeinouye.bsky.social · May 3

From a genomics & bioinformatics perspective, these new NIH policies will likely knock out the pillars of these research fields across the world. No joke. Reseachers everywhere should be aware and **non-US funders need to step up** to fill the big gaps that will appear in the coming months.

Emma Chory, Ph.D. @chorye.bsky.social · May 3

How are folks handling NIH’s no foreign subawards policy? Anyone working with big consortia (e.g. Human Protein Atlas, Sweden), this will become a massive problem—some orgs are the only source for rare reagents/proteins, and distribute them at cost. Curious the implications/plans for navigating.

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Sam Lambert @iamslambert.bsky.social · May 29

My pleasure!

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Sam Lambert @iamslambert.bsky.social · May 25

Lots of food for thought about circadian regulation during the #eshg2025 genetic epidemiology session today… 🤔 am I too sleep deprived to understand?

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Sam Lambert @iamslambert.bsky.social · May 24

@hasanga.bsky.social from @mikeinouye.bsky.social / @cambridgebaker.bsky.social @cambridge-ceu.bsky.social sharing new results for local-ancestry effects on CAD risk loci. #ESHG2025

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