Andrew Stern
@andrewmstern.bsky.social
Neurologist and Alzheimer disease scientist at Brigham and Women’s Hospital. My lab studies beta-amyloid aggregates as they occur in human brain. Also TDP-43 biomarkers. Associate PD for research at MGB neurology residency program. sternlab.bwh.harvard.edu
Hi Usha, I would be happy to discuss the misinformed narrative about the Alzheimer’s field Piller is pushing. And perhaps you or he can explain why my ongoing work and that of thousands of others is part of a “Devastating Legacy of Lies.”
December 3, 2025 at 11:31 AM
Hi Usha, I would be happy to discuss the misinformed narrative about the Alzheimer’s field Piller is pushing. And perhaps you or he can explain why my ongoing work and that of thousands of others is part of a “Devastating Legacy of Lies.”
Reposted by Andrew Stern
I fully agree. The term LLPS is probably not the correct one to describe what happens in cells.
However, the formation of dynamic low-order condensates driven by low affinity multivalent proteins (often highly disordered) seems to occur in cells.
However, the formation of dynamic low-order condensates driven by low affinity multivalent proteins (often highly disordered) seems to occur in cells.
November 30, 2025 at 4:06 PM
I fully agree. The term LLPS is probably not the correct one to describe what happens in cells.
However, the formation of dynamic low-order condensates driven by low affinity multivalent proteins (often highly disordered) seems to occur in cells.
However, the formation of dynamic low-order condensates driven by low affinity multivalent proteins (often highly disordered) seems to occur in cells.
If not LLPS, what term would you use to describe these quick off-rate polyvalent structures that show rapid FRAP recovery, droplet-mixing, etc? QuORPS?
November 16, 2025 at 11:44 PM
If not LLPS, what term would you use to describe these quick off-rate polyvalent structures that show rapid FRAP recovery, droplet-mixing, etc? QuORPS?
Well I see the appeal of using “liquid” as a term to describe a collection of polyvalent interactors, sliding along one another through rapid associations and dissociations. What would be a better term for this, distinct from aggregates with irreversible monovalent (oligovalent?) interactions?
November 16, 2025 at 7:33 PM
Well I see the appeal of using “liquid” as a term to describe a collection of polyvalent interactors, sliding along one another through rapid associations and dissociations. What would be a better term for this, distinct from aggregates with irreversible monovalent (oligovalent?) interactions?
Do you think it better to describe condensates as concentrations of disordered macromolecules with specific but polyvalent interactions and quick off-rates?
November 16, 2025 at 6:41 PM
Do you think it better to describe condensates as concentrations of disordered macromolecules with specific but polyvalent interactions and quick off-rates?
We are looking to hire a postdoc to take this and other TDP-43 assay development forward! Please re-post!
October 24, 2025 at 8:58 PM
We are looking to hire a postdoc to take this and other TDP-43 assay development forward! Please re-post!
Thanks guys. To be clear, I still favor that antibody directly binding to CAA could be a cause of ARIA. We just found that the difference in ARIA-E between lec and adu can’t be fully explained by differences in CAA preference.
May 22, 2025 at 12:51 PM
Thanks guys. To be clear, I still favor that antibody directly binding to CAA could be a cause of ARIA. We just found that the difference in ARIA-E between lec and adu can’t be fully explained by differences in CAA preference.
Reposted by Andrew Stern
