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Angelica Ronald

@angelicaronald.bsky.social

200 followers 390 following 7 posts

Professor of Psychology and Genetics at University of Surrey

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Reposted by Angelica Ronald

Dr Georgina Hosang @drhosang.bsky.social · 16d

*New paper* showing that subclinical #hypomania @ 18:
-sig linked to 14 psychiatric/neurodev diagnoses
-Highest genetic correlations: ADHD, drug & alcohol misuse
-Highest enviro correlations: psychosis, anorexia & bipolar
acamh.onlinelibrary.wiley.com/doi/full/10....
@angelicaronald.bsky.social

Reposted by Angelica Ronald

London Genetics Network @ldngenenet.bsky.social · Jul 14

Thanks to @uniofsurrey.bsky.social for funding this event.
London Genetics Network is a special interest group funded by the UK Genetic Society. If you are a researcher working in human genetics in London or the surrounding areas please email us to join the network: [email protected]

Reposted by Angelica Ronald

London Genetics Network @ldngenenet.bsky.social · Jul 14

🔔 LGN Summer Lecture! Wed 16 Jul @ UCL Bloomsbury. @dr-appie.bsky.social (Amsterdam UMC) on “Genetic Architecture of a Social Construct”. ☕ 15:30 coffee | 16:00 talk | 🤝 17:00 networking. Members: check your email for the invite from the LGN mailing list.

Reposted by Angelica Ronald

Mike Inouye @mikeinouye.bsky.social · Jun 12

Realizing the promise of genome-wide association studies for effector gene prediction www.nature.com/articles/s41...

Angelica Ronald @angelicaronald.bsky.social · Jun 10

On 26th June check out the conference @acamh.bsky.social ‘Neurodiversity: Cutting-Edge Research, Evolving Perspectives, and Effective Innovations - 2025 Jack Tizard Memorial International Conference’. www.acamh.org/event/neurod...
Talks on new research and innovative approaches to #Neurodiversity

Neurodiversity: Cutting-Edge Research, Evolving Perspectives, and Effective Innovations - 2025 Jack Tizard Memorial International Conference

'Neurodiversity: Cutting-Edge Research, Evolving Perspectives, and Effective Innovations' is the 2025 Jack Tizard Memorial Conference that brings together leading experts to explore neurodiversity res...

Reposted by Angelica Ronald

Nature @nature.com · May 31

Researchers with ADHD discuss its peaks and valleys and how they structure their work lives to succeed

https://go.nature.com/3FitQh4

Scientists with ADHD speak up: when fire meets focus

Nature - Researchers with ADHD discuss its peaks and valleys and how they structure their work lives to succeed.

Reposted by Angelica Ronald

Melanie de Wit @mmdewit.bsky.social · May 31

(9/9) It was a great pleasure working on this with Morgan Morgan, Ilan Libedinsky, Chloe Austerberry, Sander Begeer, @dr-appie.bsky.social, @angelicaronald.bsky.social and @tincatwin.bsky.social

Reposted by Angelica Ronald

Melanie de Wit @mmdewit.bsky.social · May 31

(8/9) To conclude, due to inconsistent associations and limited generalizability, we underscore that the autism polygenic score does not have clinical utility and should only be applied for scientific purposes, with improvements needed for a deeper understanding of autism’s polygenic underpinnings

Reposted by Angelica Ronald

Melanie de Wit @mmdewit.bsky.social · May 31

(7/9) We show that the autism polygenic score, as a standalone variable associates consistently with autism diagnostic status but is unable to capture the spectrum’s complex phenotypical and etiological differences and its genetic overlap with other traits and conditions.

Reposted by Angelica Ronald

Melanie de Wit @mmdewit.bsky.social · May 31

(6/9) Associations with outcomes other than those mentioned above were inconclusive and effect sizes generally small (median r = 0.03). Hence, our results suggest the autism polygenic score may lack the statistical power to adequately capture polygenic effects.

Reposted by Angelica Ronald

Melanie de Wit @mmdewit.bsky.social · May 31

(5/9) Our systematic review also revealed evidence for associations with social behavior, depression, motor skills and physical activity, although these results show incongruency over samples.

Reposted by Angelica Ronald

Melanie de Wit @mmdewit.bsky.social · May 31

(4/9) A meta-analysis of nine studies revealed strong evidence for an association between the autism polygenic score and autism diagnosis in independent cohorts (meta-analytic r = 0.158 (95% CI 0.067 – 0.249)), which supports the polygenic score’s specificity.

Reposted by Angelica Ronald

Melanie de Wit @mmdewit.bsky.social · May 31

(3/9) The latest autism GWAS, led by @jakobgrove.bsky.social led to a wealth of studies assessing the relations between the autism PGS and various phenotypes. We included a total of 72 of these studies.

Reposted by Angelica Ronald

Melanie de Wit @mmdewit.bsky.social · May 31

(2/9) 🧬Genetic factors play a substantial role in the etiology of autism and its co-occurrence with other conditions and traits. We aimed to clarify the associations between the autism polygenic score and autism diagnosis, autistic traits, and related behavioral and neurobiological traits

Reposted by Angelica Ronald

Melanie de Wit @mmdewit.bsky.social · May 31

(1/9) 📣 OUT NOW! 📣

So excited to share that our systematic review and meta-analysis on the autism polygenic score is now published in JAACAP Open @jaacapjournals.bsky.social.

doi.org/10.1016/j.ja...

A (long) thread of our main findings ⤵️

Reposted by Angelica Ronald

Daniel MacArthur @dgmacarthur.bsky.social · May 24

Excited to be in Milan for #eshg2025! If you’re interested in leading analysis of large, diverse cohorts with WGS and cellular genomic data in Australia, I’d be keen to chat - we’re looking to fill a variety of senior comp bio roles: populationgenomics.org.au/careers/ #eshg25

Careers - Centre for Population Genomics

populationgenomics.org.au

Reposted by Angelica Ronald

Ted Schwaba @tedmond.bsky.social · May 20

Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...

Reposted by Angelica Ronald

Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · May 16

Want to learn more?

Read: 'Scientists discover the genes influencing when babies take their first steps'

www.surrey.ac.uk/news/scienti....

And 'Genes influencing when babies walk discovered, and these genes affect longer-term outcomes too'

communities.springernature.com/posts/genes-...

Scientists discover the genes that influence when babies start walking | University of Surrey

www.surrey.ac.uk

Reposted by Angelica Ronald

Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · May 16

📣Out now 📣

In a GWAS meta-analysis, @angelicaronald.bsky.social and colleagues identified 11 independent genome-wide significant loci associated with age at onset of walking.

www.nature.com/articles/s41...

Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry - Nature Human Behaviour

A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and gene...

Reposted by Angelica Ronald

King's Perinatal Functional Imaging Group, Tomoki Arichi @kingspfig.bsky.social · May 8

Very excited about this important piece of work with @angelicaronald.bsky.social characterising gene associations with age of walking onset. We also show using dHCP data that these are related to volume in key brain motor regions (like the deep grey nuclei and cerebellum) even as a newborn infant

Angelica Ronald @angelicaronald.bsky.social · May 7

Our gene discovery project on age at onset of walking is out today! Find the paper here www.nature.com/articles/s41... Huge thanks to the cohorts, collaborators & coauthors, in particular first author Dr Anna Gui 1/n

Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry - Nature Human Behaviour

A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and gene...

Reposted by Angelica Ronald

Surrey Psychology @surreypsychology.bsky.social · May 7

🧬 👶 🐥 How do genes influence when a baby takes their first step?
Our colleague Prof Angelica Ronald explores this question in a fascinating new blog post on Psychology Today. Drawing on her team’s recent publ in #NatureHumanBehaviour and #NatureGenetics.
www.psychologytoday.com/us/blog/surr...

How Genes Influence the Timing of a Baby's First Step

The science behind motor milestones and learning to walk.

www.psychologytoday.com

Reposted by Angelica Ronald

Nature Human Behaviour @nathumbehav.nature.com · May 7

A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and genetic overlap with ADHD and brain phenotypes.

Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry - Nature Human Behaviour

A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and genetic overlap with ADHD and brain phenotypes.

Reposted by Angelica Ronald

University of Surrey @uniofsurrey.bsky.social · May 7

Scientists discover the genes influencing when babies take their first steps, study finds:

www.surrey.ac.uk/news/scienti...

@angelicaronald.bsky.social

Angelica Ronald @angelicaronald.bsky.social · May 7

Delighted to be able to work with you on this, @markhjoh.bsky.social !

Reposted by Angelica Ronald

Simon Fisher @profsimonfisher.bsky.social · May 7

Common DNA variants account for around a quarter of variability in age at onset of walking "...an important milestone that links genetically to a range of later health, educational & behavioural outcomes", according to new @nathumbehav.nature.com paper by @angelicaronald.bsky.social & colleagues.🧬🧪

Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry - Nature Human Behaviour

A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and gene...