Angelo Frei
@angelofrei.bsky.social
Medicinal Inorganic Chemistry Group Leader
SNSF Ambizione Fellow
2024- Lecturer in Chemistry, University of York (UK)
Dog Dad, Space Nerd, DnD Enthusiast
SNSF Ambizione Fellow
2024- Lecturer in Chemistry, University of York (UK)
Dog Dad, Space Nerd, DnD Enthusiast
Great idea, hopefully this will expand! Moving from CH-AUS-UK-CH-UK messed up any pension I had quite thoroughly!
December 3, 2025 at 9:46 AM
Great idea, hopefully this will expand! Moving from CH-AUS-UK-CH-UK messed up any pension I had quite thoroughly!
Reposted by Angelo Frei
We call these mechanism based sirtuin inhibitors SirTraps that trap the enzyme via this ADP ribose adduct onlinelibrary.wiley.com/doi/10.1002/... 2/
From Pharmacophore to Warhead: NAD+‐Targeting Triazoles as Mechanism‐Based Sirtuin Inhibitors
We report “Sirtuin Trapping Ligands” (SirTraps), mechanism-based 1,2,3-triazole inhibitors that hijack sirtuin (SIRT) catalysis to form covalent triazolium– or triazole–ADP-ribose (ADPR) adducts from...
onlinelibrary.wiley.com
November 2, 2025 at 1:20 PM
We call these mechanism based sirtuin inhibitors SirTraps that trap the enzyme via this ADP ribose adduct onlinelibrary.wiley.com/doi/10.1002/... 2/
Congratulations Ronan!
October 23, 2025 at 6:42 AM
Congratulations Ronan!