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Reposted by Anna Gloyn

pankbase.bsky.social @pankbase.bsky.social · Sep 5

Anna Gloyn (@annagloyn.bsky.social), Jie Liu, Noel Burtt, and Marcela Brissova from the PanKbase team gave a webinar for the HIRN webinar series. If you missed it and want to know how PanKbase might help compliment your type I diabetes research, watch it here: youtu.be/3qLiBdIOJhY?...

HIRN Webinar: PanKbase: A Centralized Knowledge Base of the Human Pancreas for Diabetes Research

YouTube video by Human Islet Research Network

youtu.be

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Reposted by Anna Gloyn

Academy of Medical Sciences @acmedsci.bsky.social · Jul 9

It's a big day at the Academy as we welcome our 2025 Fellows 🎉

We’re celebrating 54 remarkable scientists joining our esteemed Fellowship of 1,450 leading researchers.

📣 Meet our new Fellows: ow.ly/VtGs50WmPqc
🌟 And our Honorary Fellows: ow.ly/4syL50WmPyi

And stay tuned for highlights!

Image of a table with booklets and name tags

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Reposted by Anna Gloyn

Academy of Medical Sciences @acmedsci.bsky.social · Jul 9

🎉 Our New Fellows Admissions Day is in full swing!

We're welcoming an inspiring group of leaders advancing research and shaping the future of medicine! 💡

A man presenting at a lectern with a PowerPoint presentation behind him

A woman asking a question into a microphone

A woman presenting at a lectern with a PowerPoint presentation behind her

Two people standing and talking to each other

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Anna Gloyn @annagloyn.bsky.social · Jul 4

It was such a pleasure to collaborate 🙂

a group of people are dancing in a hallway and the word team work is visible

ALT: a group of people are dancing in a hallway and the word team work is visible

media.tenor.com

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James Russ-Silsby @jamesr-s.bsky.social · Jul 3

Really proud of this Exeter–Stanford collaboration identifying bi-allelic variants in PAX4 as a novel cause of transient neonatal diabetes—the first new genetic cause of this subtype described in over a decade. This work expands our understanding of beta cell development.
🔗 doi.org/10.1016/j.mo...

Complete Loss of PAX4 causes Transient Neonatal Diabetes in Humans

Gene discovery studies in individuals with diabetes diagnosed within 6 months of life (neonatal diabetes, NDM) can provide unique insights into the de…

www.sciencedirect.com

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pankbase.bsky.social @pankbase.bsky.social · Jul 3

Our DEG explorer enables interactive visualizations of differential gene expression within human pancreatic islets. Data was generated from the integrated single-cell RNA sequencing from 140 human donors sourced from HPAP, IIDP, and Prodo. Check out the tutorial here: youtu.be/jL8SgEMF_sg?...

PanKbase Differential Gene Expression Browser - June 2025

YouTube video by PanKbase

youtu.be

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Anna Gloyn @annagloyn.bsky.social · Jun 23

It was such a great session!!! I was honoured to present with you and Romi with superb Charing from Miriam!! 🧬

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chalab2022.bsky.social @chalab2022.bsky.social · May 25

Please check out our new paper on bioRxiv evaluating genetic background influences on heterogenous responses to S64F MAFA!: www.biorxiv.org/content/10.1...

Genetic background influences the heterogeneous phenotypes driven by the MAFAS64F MODY variant in male mice

Pancreatic β-cells require several key factors to appropriately secrete insulin to maintain euglycemia. One such factor is MafA, a transcription factor fundamental to β-cell function. We previously id...

www.biorxiv.org

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chalab2022.bsky.social @chalab2022.bsky.social · Jun 23

Thrilled and honored to be a part of this amazing session on rare genetics and GWAS in diabetes with @Romina39356029‪ @annagloyn.bsky.social and @miriam_udler ! #ADA2025

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · Jun 23

Dr. Anna Gloyn at #ADA2025: Multiomic data reveals diabetes heterogeneity, linking polygenic scores, islet traits, and regulatory networks.
@amdiabetesassn.bsky.social @annagloyn.bsky.social
#ADASciSessions #T2D #genomics #multiomics

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pankbase.bsky.social @pankbase.bsky.social · Jun 16

PanKbase #ADA spotlight: PanKbase PI, Dr. Jie Liu, Associate Professor of Computational Medicine and Bioinformatics
Michigan Medical School will be presenting during the session "Decoding Diabetes—AI-Driven Advances in Genetic Research". June 23rd 3:15 PM - 4:15 PM. Look forward to seeing you there!

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pankbase.bsky.social @pankbase.bsky.social · Jun 16

Edit to the time, Julie will now be presenting at 5:30pm.

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pankbase.bsky.social @pankbase.bsky.social · Jun 17

PanKbase #ADA poster alert!!! Dr. Ha Vu (@hahvu.bsky.social) will be presenting her work on our PanKbase platform: "PanKbase Integrated Single-Cell Map—A Comprehensive Atlas of Human Pancreatic Islets Unlocking Insights into Type 1 and Type 2 Diabetes" Sunday, June 22 at 12:30p CT (Poster 2121-LB).

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NIDDK Information Network @dknet.org · Jun 17

Planning your #ADA2025 visit? Don’t miss the NIDDK #DataScience Corner hosted by #dkNET!
📍 Between ADA Member Lounge & Product Theater 1
🗓 Visit during the reception or exhibit hours
🎉 Celebrate 75 years of #NIDDK!
🔗 dknet.org/data-science...
#ADASciSessions

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pankbase.bsky.social @pankbase.bsky.social · Jun 20

Welcome to Chicago! If you're at the 85th Scientific Sessions of the #ADA, stop by the PanKbase booth 1047 in the exhibit hall to learn about the our updated single cell browser, ask questions, or give us feedback. youtu.be/sNEGvSIjh3M?...

PanKbase Single Cell Browser Tutorial - June 2025

YouTube video by PanKbase

youtu.be

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pankbase.bsky.social @pankbase.bsky.social · Jun 18

Romina Bevacqua and PanKbase PI Anna Gloyn (@annagloyn.bsky.social) preview the presentations of #ADA session Genetic Regulation of Beta-Cell Mass and Function in Humans—Lessons from GWAS and Rare Genetics happening June 22, at 1:30 p.m. CT in Room W194 AB www.adameetingnews.org/genetic-regu...

Genetic Regulation of Beta-Cell Mass and Function in Humans—Lessons from GWAS and Rare Genetics - ADA Meeting News

Anna Gloyn, DPhil, and Romina J. Bevacqua, PhD, preview presentations at the 85th Scientific Sessions. Attendees in Chicago can watch the session in-person Sunday, June 22, at 1:30 p.m. CT.

www.adameetingnews.org

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Reposted by Anna Gloyn

pankbase.bsky.social @pankbase.bsky.social · Jun 2

Check out the platform at pankbase.org. Come see us at the 85th Scientific Sessions of the American Diabetes Association #ADA2025 #DataScience Booth 1047!!! We'd love to discuss more what we're doing and hear your feedback.

PanKbase | PanKBase

pankbase.org

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pankbase.bsky.social @pankbase.bsky.social · Jun 2

What is PanKbase? Watch our introduction video to find out: youtu.be/glGHni2tXGg?....

PanKbase Introduction Video

YouTube video by PanKbase

youtu.be

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pankbase.bsky.social @pankbase.bsky.social · Jun 9

We're less than two weeks away from #ADA2025. PanKbase, booth 1047 will be located in the NIDDK #DataScience corner. Come see us to learn more about the platform and meet the PanKbase team.

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pankbase.bsky.social @pankbase.bsky.social · Jun 10

PanKbase #ADA2025 spotlight: PI @annagloyn.bsky.social presents Sun. the 22nd at 2pm CDT. Session: Genetic Regulation of Beta-Cell Mass and Function in Humans: Lessons from GWAS and Rare Genetics. Her talk: "Integrating Multiomic Data to Understand Complex Gene Regulatory Networks in Islets"

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Daniel Drucker @danieljdrucker.bsky.social · Jun 4

Progress in Polygenic Risk Scores (PRS), which take multiple disease-modifying variants into account, are increasingly powerful tools to identify, predict and classify #diabetes mellitus @natrevendo.nature.com www.nature.com/articles/s41...

Diabetes mellitus polygenic risk scores: heterogeneity and clinical translation - Nature Reviews Endocrinology

In this Review, the authors discuss different methods for assessing polygenic risk of diabetes mellitus and the utility of polygenic risk scores in classifying and screening for diabetes mellitus. The...

www.nature.com

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Mike Inouye @mikeinouye.bsky.social · Jun 5

📣 Latest from the lab: Performance of deep-learning-based approaches to improve polygenic scores www.nature.com/articles/s41...

Its thought deep learning will substantially improve PGS but the reality is MANY have tried but no/little gain has been seen so far. Here we report our negative results.

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Vaughn Cooper @vscooper.micropopbio.org · Jun 5

Wishing I were Ferris!

🤯 40 years ago!

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Nature Reviews Endocrinology @natrevendo.nature.com · Jun 4

New content online: Diabetes mellitus polygenic risk scores: heterogeneity and clinical translation

Diabetes mellitus polygenic risk scores: heterogeneity and clinical translation

Nature Reviews Endocrinology, Published online: 04 June 2025; doi:10.1038/s41574-025-01132-wIn this Review, the authors discuss different methods for assessing polygenic risk of diabetes mellitus and the utility of polygenic risk scores in classifying and screening for diabetes mellitus. The current limitations of these scores and ways of overcoming these limitations are also covered.

www.nature.com

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Anna Gloyn @annagloyn.bsky.social · Jun 4

Out today from #HectorOrtega & #SethASharp A state of the art review on polygenic risk scores (#PRS) in diabetes. This is your #101 on what we currently know about them and their application to understanding disease heterogeneity & clinical translation.

Read for free here - rdcu.be/eprel

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