How important is #epigenetics for human brain?

Researchers led by @mareikealbert.bsky.social used brain organoids 🧠 🧫 and Epi-CyTOF to show that histone methylation controls how brain cells multiply and how big the organoid grows.

Read more ➡️ tud.link/4ywe3g

#neuroscience #CMCBnews

Enjoy our new review article discussing epigenetic-metabolic interplay in brain development! It is a nice & fun collaborative work with Mareike Albert lab @mareikealbert.bsky.social doi.org/10.1016/j.ti...

⏳🧠 Developmental timing is key during neocortex development. Our new review with @takashi-namba.bsky.social lab discusses the role of epigenetic and metabolic regulation of developmental timing in neocortex evolution.

www.sciencedirect.com/science/arti...

💫 New preprint from the lab: Comparing great ape cerebral organoids, we found that human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution. Fantastic work from super-talented PhD student Theresa Schütze!

www.biorxiv.org/content/10.1...

How do different #PRC1 complexes contribute to the regulation of #NSC fate? Side-by-side comparison of canonical and non-canonical PRC1 in #proliferation and #differentiation.

Our study is now published:
www.life-science-alliance.org/content/8/4/...

By Janine Hoffmann @crtd-tud.bsky.social

Epigenetic mechanisms regulate the capacity of stem cells to proliferate and differentiate. This study dissects the role of canonical and non-canonical PRC1 in neural stem cell fate specification @mareikealbert.bsky.social @crtd-tud.bsky.social
https://buff.ly/3CM7q6t

Interested in using sliced cortical organoids for functional studies? Check out our step-by-step protocol for electroporation!

app.jove.com/t/67598/elec...

By our incredibly skilled technician Annika Kolodziejczyk 🤩