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Antony W. Oliver (Tony)

@antonywoliver.bsky.social

91 followers 30 following 6 posts

News, views and opinions of Dr Antony W Oliver, Principal Research Fellow in the Genome Damage and Stability Centre, University of Sussex, UK @gdsc-sussex

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Antony W. Oliver (Tony) @antonywoliver.bsky.social · Sep 3

Enjoying a little rest and recuperation in Rejkyavik, Iceland.

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Reposted by Antony W. Oliver (Tony)

Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · Sep 3

#New-Paper Rass laboratory reveal DNA2 to be a gatekeeper to homologous recombination at stalled DNA replication forks, rrequired to stave off cellular senescence. Their findings provide a molecular explanation for the association of DNA2 with primordial dwarfism and cancer.

doi.org/10.1038/s415...

DNA2 enables growth by restricting recombination-restarted replication - Nature

DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

doi.org

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Antony W. Oliver (Tony) @antonywoliver.bsky.social · Aug 30

... and this one too! Again, quite amazing microscopy. Major congrats to Maria + colleagues for getting this story online.

Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · Aug 27

#NEW_PAPER

In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR).

rdcu.be/eCGxF

Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex

Nature Communications - Centromeres play an essential function in faithful chromosome segregation. Here, the authors demonstrate the mechanism by which human cells dynamically modulate the activity...

rdcu.be

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Antony W. Oliver (Tony) @antonywoliver.bsky.social · Aug 30

A bit like buses...
Nice to see this work online - there is quite the amazing amount of data in this manuscript, all power to Rob Zach + colleagues!

Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · Aug 29

#NEW_PAPER
The Hochegger laboratory + collaborators investigate the sensitivity of cancer cells to a highly selective inhibitor of human Greatwall kinase (GWL) + the BB5alpha-to-GWL expression ratio is a predictive biomarker for the cellular reponse to Greatwall-targeted therapeutics. rdcu.be/eC4Hf

The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells

Nature Communications - The authors develop and characterise a selective Greatwall inhibitor, C-604, and show that its cytotoxicity stems from PP2A-B55α hyperactivation. They identify...

rdcu.be

Reposted by Antony W. Oliver (Tony)

Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · Feb 28

Many congratulations to Dr. Will Foster on succesfully defending his PhD thesis on Greatwall Kinase (GWL); co-supervissed by Tony Oliver and Helfrid Hochegger.

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Antony W. Oliver (Tony) @antonywoliver.bsky.social · Jan 8

Snowy campus #nofilter

Antony W. Oliver (Tony) @antonywoliver.bsky.social · Jan 8

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Antony W. Oliver (Tony) @antonywoliver.bsky.social · Dec 6

Well, I’ve joined BlueSky… (at long last) and look forward to posting some stuff on here soonest. Meanwhile @gdsc-sussex.bsky.social have also made the transition!