Lightnews — Scholar-powered news

Reposted by Adrien Peyrache

Dan Levenstein @dlevenstein.bsky.social · 5h

The Wu Tsai Institute at Yale is hiring another faculty member in neurocomputation. Come work with us in a growing community at the interface of neuroscience and AI!

More info below 👇

Wu Tsai Institute | Yale University @wutsaiyale.bsky.social · 5d

📣 WTI is hiring faculty positions! Are you interested in advancing our understanding of the brain + how it gives rise to cognition?

Two calls are open:

Open-rank search, Neurocomputation, deadline: 12.1.25
Senior search, Neurodevelopment, rolling review

🔗 wti.yale.edu/opportunities

#KnowTogether

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Adrien Peyrache @apeyrache.bsky.social · 23h

Every neuroscience lecture ever, summarized in one dog video.

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manfredic.bsky.social @manfredic.bsky.social · 6d

I’m pleased to share our new paper, “Hippocampal ripple diversity organizes neuronal reactivation dynamics in the offline brain”, out in @cp-neuron.bsky.social !

With @vitorlds.bsky.social and David Dupret, we show that diversity in ripple current profiles shapes reactivation dynamics

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Boris Bernhardt @borismontreal.bsky.social · 6d

🚨 New paper in Nature Methods:
HippoMaps: multiscale cartography of the human hippocampus

Open-source tools & data to explore structure and function of the 🍤🧠 (histology, in/ex vivo MRI, iEEG)

Led by @jordandekraker.bsky.social

docs: hippomaps.readthedocs.io
paper: doi.org/10.1038/s415...

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Kevin Mitchell @wiringthebrain.bsky.social · 6d

Just the most remarkable person and truly a beautiful soul

The New York Times @nytimes.com · 6d

Breaking News: Jane Goodall, one of the world’s most revered conservationists, died at 91. Her discoveries in the 1960s about how chimpanzees behaved in the wild broke new ground and represented what was called “one of the Western world’s great scientific achievements.” nyti.ms/42kpGxt

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D. Earl Stephens @dearlstephens.bsky.social · 6d

🕊️ The world has lost a revered conservationist -- a colossal power for what is truly good.

🕊️ Jane Goodall is a legend who helped open the door to science to the best humans among us: woman.

🕊️ She was brave, brilliant and introduced us to the best things among us: animals.

🕊️ I grieve her passing.

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Brokoslaw Laschowski @drlaschowski.bsky.social · Sep 5

Come join us at University of Toronto. We're hiring a Professor of computational cognitive neuroscience.

#neuroAI #compneuro jobs.utoronto.ca/job/Toronto-...

Professor - Computational Cognitive Neuroscience

jobs.utoronto.ca

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Adrien Peyrache @apeyrache.bsky.social · 16d

Thanks Richard. Reminding you our little run in Chile? ;)

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Adrien Peyrache @apeyrache.bsky.social · 16d

Post-tenure mid-life crisis project: complete ✅

3h27 at the marathon (PB!) and one very happy (if slightly zombie-like) man. Recovery phase starts now…

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Adrien Peyrache @apeyrache.bsky.social · 19d

Fascinating work! It pinpoints the origin of dopaminergic signaling as a filter of striatal activity computing temporal difference.
Excited to dig into this manuscript.

Malcolm Campbell @malcolmgcampbell.bsky.social · 19d

🚨Our preprint is online!🚨

www.biorxiv.org/content/10.1...

How do #dopamine neurons perform the key calculations in reinforcement #learning?

Read on to find out more! 🧵

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Adrien Peyrache @apeyrache.bsky.social · 19d

So happy to see Morgane Butler, a former and brilliant undergrad student in the lab, publishing her PhD work. Looks super interesting.

www.nature.com/articles/s41...

Repeated head trauma causes neuron loss and inflammation in young athletes - Nature

Repetitive head impacts from contact sports are associated with brain inflammation, vascular damage and neuron loss that are independent of hyperphosphorylated tau pathology.

www.nature.com

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Adrien Peyrache @apeyrache.bsky.social · 20d

Beautiful work showing a link between hippocampal theta sequence and learning, but not subsequent replay.

Abhilasha Joshi, PhD @rhythmicspikes.bsky.social · 20d

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🚨 New preprint! 🚨

Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇

📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩

#neuroskyence

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Adrien Peyrache @apeyrache.bsky.social · 20d

Congrats! Super interesting study.

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Dan Levenstein @dlevenstein.bsky.social · 21d

Turns out BTSP is not All You Need™️?

Adrien Peyrache @apeyrache.bsky.social · 21d

« Diverse calcium dynamics underlie place field formation in hippocampal CA1 pyramidal cells. »

A fundamental study now published @elife.bsky.social

elifesciences.org/reviewed-pre...

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Adrien Peyrache @apeyrache.bsky.social · 21d

« Diverse calcium dynamics underlie place field formation in hippocampal CA1 pyramidal cells. »

A fundamental study now published @elife.bsky.social

elifesciences.org/reviewed-pre...

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Adrien Peyrache @apeyrache.bsky.social · 21d

Congrats Luke!!

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Guillaume Viejo @guillaumeviejo.bsky.social · 21d

Finally preprinted! TL;DR: thalamic head-direction neurons can shape their activity regardless of input. Big thanks to @apeyrache.bsky.social and master experimentalist @sskromne.bsky.social .

Adrien Peyrache @apeyrache.bsky.social · 22d

🚨New preprint alert!

The thalamus has long been seen as a relay of sensory signals to cortex.
But could it also generate its own structured activity?
Our study explores this question in the head-direction (HD) system.

Some explanation 🧵👇 1/13

www.biorxiv.org/content/10.1...

Coherent dynamics of thalamic head-direction neurons irrespective of input

While the thalamus is known to relay and modulate sensory signals to the cortex, whether it also participates in active computation and intrinsic signal generation remains unresolved. The anterodorsal...

www.biorxiv.org

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Adrien Peyrache @apeyrache.bsky.social · 22d

thanks!

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Adrien Peyrache @apeyrache.bsky.social · 22d

Merci ;)

Adrien Peyrache @apeyrache.bsky.social · 22d

Hope you enjoy the read, and we’d love to hear your thoughts and comments!

Fin/13

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Adrien Peyrache @apeyrache.bsky.social · 22d

Huge thanks to @guillaumeviejo.bsky.social and @sskromne.bsky.social for this amazing piece of work 💪

It’s been a long journey. These experiments are truly heroic: the LMN is only ~100 µm wide and sits 6 mm deep… not easy to hit with a silicon probe! 🧠🎯

12/13

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Adrien Peyrache @apeyrache.bsky.social · 22d

In conclusion, like many other recent studies, this work shows that the thalamus is not just a relay. Here we show it can certainly generate coherent internal dynamics on its own.

11/13

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Adrien Peyrache @apeyrache.bsky.social · 22d

Our model showed that divergent LMN inputs, local inhibition, and strong non-linear thresholds are sufficient for the ADN to form coherent pop. activity, even from random input
We predict that thalamic inhibition is crucial for this phenomenon & does certainly more than what we suggest here.
10/13

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Adrien Peyrache @apeyrache.bsky.social · 22d

How s this possible? Unlike cortex, the thalamus lacks local excitatory loops.
We found ADN neurons switch abruptly between silent and active states, a non-linear firing mode that can create structure from noise.
This was described by @dlevenstein.bsky.social

www.biorxiv.org/content/10.1...

9/13

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Adrien Peyrache @apeyrache.bsky.social · 22d

We silenced cortical feedback and saw LMN activity collapse into noise during non-REM, showing LMN relies on cortex to stay organized in sleep.

In the same condition, ADN neurons remained tightly coordinated even when PSB was silenced, showing the thalamus can self-organize coherent dynamics

8/13

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