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Reposted by Abhilasha Joshi, PhD

Aaron Milstein @neurosutras.bsky.social · 6d

Interesting new data on BTSP mechanisms from my old Janelia colleague @hiallen72.bsky.social
www.biorxiv.org/content/10.1...

Ca2+ Plateau Potentials Reflect Cross-Theta Cortico-Hippocampal Input Dynamics and Acetylcholine for Rapid Formation of Efficient Place-Cell Code

A central tenet of Systems Neuroscience lies in an understanding of memory and behavior through learning rules, but synaptic plasticity has rarely been shown to create functional single-neuron code in...

www.biorxiv.org

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Reposted by Abhilasha Joshi, PhD

Blake Richards @tyrellturing.bsky.social · 23d

For those interested in open neuroscience learning tools, check out the preprint for “RetINaBox: A hands-on tool for experimental neuroscience" that a couple students in my lab worked on in collaboration with the Trenholm lab:

www.biorxiv.org/content/10.1...

🧠📈 🧪

RetINaBox: A hands-on learning tool for experimental neuroscience

An exciting aspect of neuroscience research is developing and testing hypotheses via experimentation. However, due to logistical and financial hurdles, this compelling part of neuroscience research is...

www.biorxiv.org

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Reposted by Abhilasha Joshi, PhD

Colin Hoy @colinwhoy.bsky.social · 9d

Really incredible work to tease apart the contributions of theta oscillations and hippocampal replay! Great evidence that theta is coordinating pairs and populations of neurons, which is necessary for learning

Abhilasha Joshi, PhD @rhythmicspikes.bsky.social · 21d

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🚨 New preprint! 🚨

Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇

📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩

#neuroskyence

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Abhilasha Joshi, PhD @rhythmicspikes.bsky.social · 8d

… particular brain states matter most — so we can study & target those precise circuits/states in situations of disfunction.

(Experiments were planning to build in the lab but we are just getting started so will need to wait 💁🏽‍♀️)

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Abhilasha Joshi, PhD @rhythmicspikes.bsky.social · 8d

… even though the animals completed as many trials and immobility-related activity remained intact.

The precise mechanisms may vary across species, but these studies underscore how crucial it is to identify when (i.e. in which learning stage) and where (i.e. which circuits / oscillatory states) …

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Abhilasha Joshi, PhD @rhythmicspikes.bsky.social · 8d

(Sorry missed this. These studies are really important!)

What our these results really made me realize is how dissociable brain states are at both temporal and circuit levels. Just manipulating theta sequences during learning (in a hippocampus-dependent task) was enough to disrupt learning …

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Reposted by Abhilasha Joshi, PhD

Katrin Vogt @katrinvogt.bsky.social · 12d

How is valence computed in the brain? Check out our new preprint about a single cell that integrates excitatory and inhibitory input across modalities according to valence and impacts behavioral decisions. An exciting collaboration across many labs. Enjoy reading!
www.biorxiv.org/content/10.1...

A multisensory, bidirectional, valence encoder guides behavioral decisions

A key function of the brain is to categorize sensory cues as repulsive or attractive and respond accordingly. While we have some understanding of how sensory information is processed in the sensory pe...

www.biorxiv.org

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Reposted by Abhilasha Joshi, PhD

Wolf-Julian Neumann @julianneumann.bsky.social · 14d

New paper in Nature Biomedical Engineering by @timonmerk.bsky.social !

We built a platform that unites AI-based brain signal decoding with connectomics across 123 hours of recordings from 73 patients. A step toward adaptive, network-level neurotechnology.

www.nature.com/articles/s41...

Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants - Nature Biomedical Engineering

A modularized open-source pipeline for invasive brain signal decoding bridges the gap between closed-loop neuromodulation and clinical brain–computer interface approaches in a large patient cohort.

www.nature.com

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Reposted by Abhilasha Joshi, PhD

eartha mae @endoeartha.bsky.social · 13d

Very excited and proud to share my postdoctoral research with @neurrriot.bsky.social looking at the context-specific encoding of social behavior 💃🕺 in hormone-sensitive, large-scale brain networks in mice!

www.biorxiv.org/content/10.1...

#neuroskyence #compneurosky 🧪
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Reposted by Abhilasha Joshi, PhD

clykken.bsky.social @clykken.bsky.social · 14d

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How can the brain create countless unique memories using a single, universal metric of space? We’ve been waiting for the answer to this for two decades!
Read it here:
www.biorxiv.org/content/10.1...

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Abhilasha Joshi, PhD @rhythmicspikes.bsky.social · 13d

How interesting! Going on the reading list. Congratulations @clykken.bsky.social 👏🏽

Abhilasha Joshi, PhD @rhythmicspikes.bsky.social · 14d

What an excellent read ✅👏🏽

Highly recommend! I loved how the author (Evelyn Fox Keller) really dived deep into the concept of “understanding” or a feeling for the organism and on the role of “intuition” in making discoveries.

A lot to think about too: few permanent positions, science in war …!

Good science cannot proceed without a deep emotional investment on the part of the scientist.

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Reposted by Abhilasha Joshi, PhD

George Dragoi @georgedragoi.bsky.social · 18d

Interesting theta sequence-replay-learning relationships! Consistent with Winson's '78 work on theta disruption impairing learning and our (Farooq & Dragoi '19; DOI: 10.1126/science.aav0502) work on emergence of preplay and waking rest replay prior to theta sequences during rat postnatal development

Abhilasha Joshi, PhD @rhythmicspikes.bsky.social · 21d

1/
🚨 New preprint! 🚨

Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇

📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩

#neuroskyence

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Reposted by Abhilasha Joshi, PhD

Neurodata Without Borders @nwb.org · Aug 18

NWB just turned 10 years old! Researchers worldwide have downloaded 1.9 PB of NWB data from @dandiarchive.org. This animation shows the reach of NWB, facilitating collaboration across the globe. What impact has open neurophysiology data had on your science? Share your stories! 🧠

@openscience

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Abhilasha Joshi, PhD @rhythmicspikes.bsky.social · 18d

Thanks @arnaghosh.bsky.social 🙌🏽

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Abhilasha Joshi, PhD @rhythmicspikes.bsky.social · 19d

I’d watch this movie 😍🍿🥤

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Abhilasha Joshi, PhD @rhythmicspikes.bsky.social · 20d

On the point about functional dissociation: maybe I can clarify that it was about “whether theta sequences during locomotion are necessary for observing the sequential structure in reply”

We have evidence that they are not necessary & hence the two may be part of separate underlying computations.

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Abhilasha Joshi, PhD @rhythmicspikes.bsky.social · 20d

semi yes 😬 Thing is we don’t know (I think) what memory looks like (is it theta sequences or it is replay or something else). Same for learning.

The interesting thing is here is that replay structure is intact (whatever we have measured) & animals still can’t seem to do better at the task.

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Abhilasha Joshi, PhD @rhythmicspikes.bsky.social · 20d

Thanks Gaurav 🙌🏽

Abhilasha Joshi, PhD @rhythmicspikes.bsky.social · 20d

Thank you 😊 please do let us know if you have any feedback 🙌🏽

a cartoon character is dancing in front of a crowd

ALT: a cartoon character is dancing in front of a crowd

media.tenor.com

Abhilasha Joshi, PhD @rhythmicspikes.bsky.social · 20d

Thank @laurelinelogiaco.bsky.social 😻

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Abhilasha Joshi, PhD @rhythmicspikes.bsky.social · 20d

Thanks @gbouvier.bsky.social 💁🏽‍♀️

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Abhilasha Joshi, PhD @rhythmicspikes.bsky.social · 20d

Thank you 🙌🏽

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Abhilasha Joshi, PhD @rhythmicspikes.bsky.social · 20d

Thanks @apeyrache.bsky.social went through multiple rounds of disbelieving but that’s the data 🫡

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Abhilasha Joshi, PhD @rhythmicspikes.bsky.social · 20d

Thanks yeah — was the first time testing the code/data sharing during bioarxiv submission process. Took a village (&Sam Bray’s) support to get that done but I’m really happy with how the manuscript turned out and happy to share data/code too while making claims 😬

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