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Reposted by Wolf-Julian Neumann

Neuroengineering @neuroengineering.bsky.social · 12d

Better neural decoding using connectomics and emotional states? Check out @julianneumann.bsky.social newest study in Nature Biomed. Eng!

#neuroskyence #bci #compneurosky

Wolf-Julian Neumann @julianneumann.bsky.social · 14d

New paper in Nature Biomedical Engineering by @timonmerk.bsky.social !

We built a platform that unites AI-based brain signal decoding with connectomics across 123 hours of recordings from 73 patients. A step toward adaptive, network-level neurotechnology.

www.nature.com/articles/s41...

Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants - Nature Biomedical Engineering

A modularized open-source pipeline for invasive brain signal decoding bridges the gap between closed-loop neuromodulation and clinical brain–computer interface approaches in a large patient cohort.

www.nature.com

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Reposted by Wolf-Julian Neumann

Andreas Horn @andreashorn.org · 14d

🔥🔥🔥Glad to see this finally out – huge congratulations to @timonmerk.bsky.social & @julianneumann.bsky.social & team!!

Wolf-Julian Neumann @julianneumann.bsky.social · 14d

New paper in Nature Biomedical Engineering by @timonmerk.bsky.social !

We built a platform that unites AI-based brain signal decoding with connectomics across 123 hours of recordings from 73 patients. A step toward adaptive, network-level neurotechnology.

www.nature.com/articles/s41...

Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants - Nature Biomedical Engineering

A modularized open-source pipeline for invasive brain signal decoding bridges the gap between closed-loop neuromodulation and clinical brain–computer interface approaches in a large patient cohort.

www.nature.com

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Reposted by Wolf-Julian Neumann

Prof. Vladimir Litvak @vlitvak.bsky.social · 14d

Looks amazing! Congratulations!

Wolf-Julian Neumann @julianneumann.bsky.social · 14d

New paper in Nature Biomedical Engineering by @timonmerk.bsky.social !

We built a platform that unites AI-based brain signal decoding with connectomics across 123 hours of recordings from 73 patients. A step toward adaptive, network-level neurotechnology.

www.nature.com/articles/s41...

Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants - Nature Biomedical Engineering

A modularized open-source pipeline for invasive brain signal decoding bridges the gap between closed-loop neuromodulation and clinical brain–computer interface approaches in a large patient cohort.

www.nature.com

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Wolf-Julian Neumann @julianneumann.bsky.social · 14d

This has been a huge collaborative effort across Berlin, Boston and Beijing. I am truly grateful for the fantastic team spirit that has allowed us to develop this platform together.

a cartoon of tweety and jerry saying they are a team .

ALT: a cartoon of tweety and jerry saying they are a team .

media.tenor.com

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Wolf-Julian Neumann @julianneumann.bsky.social · 14d

The bigger picture: AI + connectomics are reshaping neurotechnology. Have a look at our recent perspective in Nature Reviews Neurology www.nature.com/articles/s41...

From adaptive deep brain stimulation to adaptive circuit targeting - Nature Reviews Neurology

Deep brain stimulation (DBS) is a highly effective treatment option for movement disorders and is also being explored for other brain disorders. This Perspective proposes a unified framework, termed adaptive circuit targeting, which combines adaptive and connectomic DBS to enable decoding of symptom severity from brain signals and activation of relevant symptom-response circuits.

www.nature.com

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Wolf-Julian Neumann @julianneumann.bsky.social · 14d

Inspired by @andreashorn.org, the core is connectomics-informed decoding: each electrode contact is mapped to a “fingerprint” of whole-brain connectivity, which predicts decoding performance. This enables out-of-cohort generalization without patient-specific training. is the innovator.

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Wolf-Julian Neumann @julianneumann.bsky.social · 14d

For epilepsy, we optimized seizure detection using AI-guided parameter discovery. Connectomics revealed a distributed seizure network (hippocampus, cingulate, occipital cortex), enabling more accurate, personalized detection. Our parameters were constrained to device capabilities.

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Wolf-Julian Neumann @julianneumann.bsky.social · 14d

In depression, we decoded emotional states from the subgenual cingulate. Better decoding correlated with clinical outcomes after DBS, and network maps aligned with known TMS targets. A link between invasive decoding and non-invasive therapy for the next-generation of AI inspired neuromodulation.

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Wolf-Julian Neumann @julianneumann.bsky.social · 14d

For movement disorders, connectomics-informed decoders generalized across Parkinson’s and epilepsy patients. Plug-and-play decoding without per-patient calibration triggered adaptive DBS in a newly recruited patient. #cebra outperformed other decoder architectures.

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Wolf-Julian Neumann @julianneumann.bsky.social · 14d

Traditional brain–computer interfaces (BCIs) often need individual retraining for every patient. Our approach shows that generalizable decoders can work across cohorts in Europe, the US, and China—sometimes even outperforming individual models. The platform translates offline data to real-time.

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Wolf-Julian Neumann @julianneumann.bsky.social · 14d

New paper in Nature Biomedical Engineering by @timonmerk.bsky.social !

We built a platform that unites AI-based brain signal decoding with connectomics across 123 hours of recordings from 73 patients. A step toward adaptive, network-level neurotechnology.

www.nature.com/articles/s41...

Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants - Nature Biomedical Engineering

A modularized open-source pipeline for invasive brain signal decoding bridges the gap between closed-loop neuromodulation and clinical brain–computer interface approaches in a large patient cohort.

www.nature.com

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Reposted by Wolf-Julian Neumann

Allen Institute @alleninstitute.org · Sep 4

Fentanyl is 100x stronger than morphine and it's reshaping the public health landscape.

In a new #LabNotes episode, dive into the neuroscience of addiction and the human stories behind the crisis: alleninstitute.org/news/lab-not...

Feat. researchers Christian Luscher and Seattle's Recovery Cafe.

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Reposted by Wolf-Julian Neumann

Alexander Mathis @trackingskills.bsky.social · Sep 4

Something exciting just left the gym -- meet Arnold the first generalist musculoskeletal control policy!

The human body has 600+ muscles, yet we seamlessly coordinate them for everything from whispering a syllable to felling a forrest. How? www.arxiv.org/abs/2508.18066

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Reposted by Wolf-Julian Neumann

Mackenzie Weygandt Mathis @trackingactions.bsky.social · Sep 4

I might be biased, but I think this is one of the most exciting developments in generalized musculoskeletal control in years ⬇️. Congrats to the team (I’m not involved!) 💪🔥

Alexander Mathis @trackingskills.bsky.social · Sep 4

Something exciting just left the gym -- meet Arnold the first generalist musculoskeletal control policy!

The human body has 600+ muscles, yet we seamlessly coordinate them for everything from whispering a syllable to felling a forrest. How? www.arxiv.org/abs/2508.18066

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Reposted by Wolf-Julian Neumann

Michael Fox @foxmdphd.bsky.social · Sep 5

Can connectomic DBS go beyond where to stimulate to inform who and when? Great discussion @dbsthinktank.bsky.social with @rolstonjohn.bsky.social @julianneumann.bsky.social suggest yes! @braincircuits.bsky.social

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Reposted by Wolf-Julian Neumann

Lukas Goede @lukasgoede.bsky.social · Sep 4

What might the future of deep brain stimulation look like?

Not just continuous stimulation, but decoding symptoms in real time and directing stimulation to the right brain circuits.

Fascinating perspective article by @andreashorn.org & @julianneumann.bsky.social in @natrevneurol.nature.com:

Andreas Horn @andreashorn.org · Sep 3

In #DeepBrainStimulation

the two major developments across the last decade have been

1. Adaptive DBS and
2. Connectomic DBS

In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:

Could the two be united into a common framework?

www.nature.com/articles/s41...

A 🧵

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Reposted by Wolf-Julian Neumann

Andreas Horn @andreashorn.org · Sep 3

In #DeepBrainStimulation

the two major developments across the last decade have been

1. Adaptive DBS and
2. Connectomic DBS

In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:

Could the two be united into a common framework?

www.nature.com/articles/s41...

A 🧵

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Reposted by Wolf-Julian Neumann

Yuchao Wang @itsyuchao.bsky.social · Aug 28

🚨 New paper alert!
Excited to share our latest work in Movement Disorders:
“Somato-Cognitive Action Network in Focal Dystonia”
👉 doi.org/10.1002/mds....

We found asynchrony between SCAN and cerebellum in different dystonia subtypes. Thread below.
#dystonia #fMRI #PrecisionFunctionalMapping #neuro

Somato‐Cognitive Action Network in Focal Dystonia

Background The central pathology causing idiopathic focal dystonia remains unclear. The recently identified somato-cognitive action network (SCAN) has been implicated. Objective We tested whether ...

doi.org

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Reposted by Wolf-Julian Neumann

Andreas Horn @andreashorn.org · Aug 22

🚨 New preprint out! 🚨
“Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application”
🔗 doi.org/10.1101/2025...

🧵 A short thread:

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Reposted by Wolf-Julian Neumann

Mackenzie Weygandt Mathis @trackingactions.bsky.social · Aug 19

So great to meet up with the talented @julianneumann.bsky.social today! His work on merging neuro, AI, and clinical applications is very exciting. He was the first to use and extend #CEBRA for human experiments 🚀🧠 #neuroskynce

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Wolf-Julian Neumann @julianneumann.bsky.social · Aug 19

Starstruck to be in the presence of one of the most disruptive and inspiring AI and neuroscientists. I loved the recent Cell cover story by Mackenzie on decoding the brain, check it out of you haven't: www.cell.com/cell/fulltex...

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Reposted by Wolf-Julian Neumann

Michael Okun @michaelokun.bsky.social · May 26

When location is everything: Why does brain ‘real estate’ determine the success of focused ultrasound (FUS) and DBS? Ever notice how the difference between success and struggle in FUS and DBS may come down to just a few millimeters? Precise placement is common to be THE deciding factor in outcome.

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Reposted by Wolf-Julian Neumann

Andreas Horn @andreashorn.org · Jun 7

Is it time to standardize preoperative imaging for deep brain stimulation?
Christoph Guettler & Anna Tietze say yes in @imagingneurosci.bsky.social – a thread 🧵

direct.mit.edu/imag/article...

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Reposted by Wolf-Julian Neumann

Isaiah Kletenik @isaiahneuro.bsky.social · Feb 13

Reduced function or injury to the frontal pole may increase creativity by disengaging the self-monitoring & cognitive control actions of the frontal pole to allow novelty seeking & creativity to be unleashed. @braincircuits.bsky.social @foxmdphd.bsky.social @julianneumann.bsky.social

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Reposted by Wolf-Julian Neumann

Andreas Horn @andreashorn.org · Apr 16

Probably the most insightful and most important paper on physiomarkers of subthalamic DBS in a long while. Bravo @julianneumann.bsky.social @tsbinns.com and team!!

Out at @natcomms.nature.com:
www.nature.com/articles/s41...

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