apoetsch.bsky.social
Anna Poetsch
@apoetsch.bsky.social
2.3K followers 290 following 65 posts
Computational Biologist at TU Dresden. Interested in how genomes encode their own stability.
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apoetsch.bsky.social
Anna Poetsch @apoetsch.bsky.social · 7d
Thank you for having me, it was really a very informative, stimulating and motivating few days!
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apoetsch.bsky.social
Anna Poetsch @apoetsch.bsky.social · 7d
It was a pleasure to talk Genome Stability for a few days with the DFG - FOR5504 for. It is really exciting to see the community in and around Cologne looking for genome stability in whole organisms and the context of the sequence. I am excited about what else is going to come.
bjornschumacher.bsky.social
Björn Schumacher @bjornschumacher.bsky.social · 8d
Amazing retreat of the @dfg.de Research Unit FOR5504 on the Physiological Causes and Consequences of Genome Instability and the Institute for Genome Stability in Aging and Disease with keynotes by @apoetsch.bsky.social and @garinis.bsky.social
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apoetsch.bsky.social
Anna Poetsch @apoetsch.bsky.social · 11d
Me: I got a new type of compliment from an audience member: "Your talk was so Gen Z"
My lab: This was not a compliment...
Me: 🥲 (but..., but..., I still think it was meant to be one...)
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Reposted by Anna Poetsch
apoetsch.bsky.social
Anna Poetsch @apoetsch.bsky.social · 13d
I am happy to share some thoughts on using AI to generate viruses (in German). www.spiegel.de/wissenschaft...
(S+) Künstliche Intelligenz: KI-designtes Virus tötet Kolibakterien
US-Forscher haben mithilfe von künstlicher Intelligenz Viren hergestellt und ihnen bestimmte Eigenschaften gegeben, weltweit sind sie damit wohl die Ersten. Die Möglichkeit KI-generierten Lebens schei...
www.spiegel.de
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Reposted by Anna Poetsch
apoetsch.bsky.social
Anna Poetsch @apoetsch.bsky.social · 13d
The ARD Wissenschaftsredaktion talked to me about AI generated viruses. Interested? Here you can listen to it (in German). www.swr.de/leben/gesund...
Die ersten KI-generierten Viren als Hoffnung im Kampf gegen resistente Bakterien
Forschende aus Stanford haben erstmals Viren entwickelt, die von einer KI entworfen wurden. Einige dieser KI-Viren konnten antibiotikaresistente Bakterien infizieren und abtöten - ein möglicher Durchb...
www.swr.de
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apoetsch.bsky.social
Anna Poetsch @apoetsch.bsky.social · 13d
There is a new Master of Physics of Life in the house. Congratulations, Adnan! Well done! It was really a superb Defense!
@poldresden.bsky.social
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apoetsch.bsky.social
Anna Poetsch @apoetsch.bsky.social · 13d
The ARD Wissenschaftsredaktion talked to me about AI generated viruses. Interested? Here you can listen to it (in German). www.swr.de/leben/gesund...
Die ersten KI-generierten Viren als Hoffnung im Kampf gegen resistente Bakterien
Forschende aus Stanford haben erstmals Viren entwickelt, die von einer KI entworfen wurden. Einige dieser KI-Viren konnten antibiotikaresistente Bakterien infizieren und abtöten - ein möglicher Durchb...
www.swr.de
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apoetsch.bsky.social
Anna Poetsch @apoetsch.bsky.social · 13d
I am happy to share some thoughts on using AI to generate viruses (in German). www.spiegel.de/wissenschaft...
(S+) Künstliche Intelligenz: KI-designtes Virus tötet Kolibakterien
US-Forscher haben mithilfe von künstlicher Intelligenz Viren hergestellt und ihnen bestimmte Eigenschaften gegeben, weltweit sind sie damit wohl die Ersten. Die Möglichkeit KI-generierten Lebens schei...
www.spiegel.de
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apoetsch.bsky.social
Anna Poetsch @apoetsch.bsky.social · 13d
Dear CRC TRR 341, thanks for having me. It was fascinating to learn more about the genomes of plants in their ecological context!
trr341.bsky.social
CRC TRR 341 "Plant Ecological Genetics" @trr341.bsky.social · 14d
Our 5th Internal Progress Colloquium is coming to an end! Two days full of scientific interactions. Honoured to have with us Caroline Müller (Bielefeld University) and @apoetsch.bsky.social! Our ECRs have progressed enormously and this makes us so happy!
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apoetsch.bsky.social
Anna Poetsch @apoetsch.bsky.social · 29d
I have already been part of your movement without knowing :-)
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Reposted by Anna Poetsch
craigandersn.bsky.social
Craig Anderson @craigandersn.bsky.social · Aug 19
Would you like to do some unique experiments in cancer genomics and mutagenesis, in beautiful Munich? Well then apply for this PhD position: jobs.dkfz.de/en/jobs/1679...

You'll learn a lot and it'll be fun and interesting!
#DKTK @dkfz.bsky.social @lmumuenchen.bsky.social
PhD Student in Mutational Processes Driving Somatic Evolution
jobs.dkfz.de
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apoetsch.bsky.social
Anna Poetsch @apoetsch.bsky.social · Aug 12
Exciting to see the @grunewaldlab.bsky.social finding new target candidates against metastases of Ewing sarcoma.
It makes one wonder how general this pathway disruption might be and whether it may work with other sarcomas or metastatic cancers in general… 🤔
grunewaldlab.bsky.social
Grünewald Lab @grunewaldlab.bsky.social · Aug 11
Very proud on our stellar Alina Ritter for her frist first-author paper:

Targeting CXADR-mediated AKT signaling suppresses tumorigenesis and enhances #chemotherapy efficacy in #Ewing #sarcoma

tinyurl.com/3kcs3bc9

@dkfz.bsky.social
@uniheidelberg.bsky.social
@nct-heidelberg.bsky.social
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Anna Poetsch @apoetsch.bsky.social · Jul 31
"i think every participant will treasure the experience forever ❤️"
Yes ☺️
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apoetsch.bsky.social
Anna Poetsch @apoetsch.bsky.social · Jul 31
We have a postdoc position for a project that is very analogous. The deadline has passed, but feel free to still apply, if you are interested. 🧵 6/6
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Anna Poetsch @apoetsch.bsky.social · Jul 31
Such an interdisciplinary interaction also makes ways back to the clinic short, so we hope that these findings can lead to predictive biomarkers for treatment response. Or does modulating NFkB signaling maybe even have potential as a co-treatment strategy 🤔? 🧵 5/6
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Anna Poetsch @apoetsch.bsky.social · Jul 31
A big shoutout to the Stange Lab at UK Dresden (www.uniklinikum-dresden.de/de/das-klini...), who are building up a very valuable resource with models for gastrointestinal tumours, on which studies like this are based. 🧵 4/6
Stange Lab - Gastrointestinal stem cell and cancer biology
www.uniklinikum-dresden.de
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Anna Poetsch @apoetsch.bsky.social · Jul 31
We find changes in the clonal dynamics, but the most striking treatment-related change is the downregulation of inflammatory NFkB signaling in a subpopulation of cells, independent of the genetics of the tumor. This transcriptional memory persists in the organoids without an immune system. 🧵 3/6
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Anna Poetsch @apoetsch.bsky.social · Jul 31
In this paper we used data from patient derived organoids from adenomas of the gastroesophageal junction treated with neoadjuvant FLOT chemotherapy in the patient, or of the organoids from the untreated tumour. We reconstructed the clonal dynamics and integrated the single cell transcriptomes.🧵 2/6
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Anna Poetsch @apoetsch.bsky.social · Jul 31
We are happy to present a new paper on gastric tumour evolution in response to peri-operative chemotherapy. www.biorxiv.org/content/10.1... 🧵 1/6
Tumor clone dynamics in gastro-esophageal cancer organoids reveal a non-genetic memory of neoadjuvant chemotherapy via downregulation of NFκB signaling
Adenocarcinomas of the gastroesophageal junction exhibit genetic and non-genetic heterogeneity that impact clinical outcomes, though the underlying mechanisms behind drug resistance remain poorly unde...
www.biorxiv.org
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apoetsch.bsky.social
Anna Poetsch @apoetsch.bsky.social · Jul 30
We find that both the 🧬 sequence and the epigenome contribute essential information and the models perform best, when trained on both. But who contributes what? To answer this, interpretable machine learning helps and it is in the paper 😉 🧵 4/4
apoetsch.bsky.social
Anna Poetsch @apoetsch.bsky.social · Jul 30
For this we use our 🧬-language model, GROVER www.nature.com/articles/s42..., and classical machine learning. 🧵 3/4
DNA language model GROVER learns sequence context in the human genome - Nature Machine Intelligence
Genomes can be modelled with language approaches by treating nucleotide bases A, C, G and T like text, but there is no natural concept of what the words would be and whether there is even a ‘language’...
www.nature.com
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apoetsch.bsky.social
Anna Poetsch @apoetsch.bsky.social · Jul 30
In this paper we disentangle what determines the genomic location of 🧬-double strand breaks looking at the 🧬 sequence and the epigenome 🧵 2/4
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Anna Poetsch @apoetsch.bsky.social · Jul 30
We are happy to present a new paper on the sequence dependence of 🧬-double strand breaks. www.biorxiv.org/content/10.1...
🧵 1/4
Using the DNA language model, GROVER, to parse sequence and epigenetic effects on genome stability
Genome stability is shaped by DNA sequence and epigenomic context, but their relative contributions to double-strand break (DSB) sensitivity remain unclear. We show that the DNA language model, GROVER...
www.biorxiv.org
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apoetsch.bsky.social
Anna Poetsch @apoetsch.bsky.social · Jul 29
Usually aggressive food preparation (vegetarian)
apoetsch.bsky.social
Anna Poetsch @apoetsch.bsky.social · Jul 29
I do. Only the tips, but recurrently so.
Also 🐙, if you can call the tips of the arms fingers….
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