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Reposted by Rosie Jackson

Dementia Researcher @dementiaresearcher.bsky.social · 29d

Postdoctoral Researcher Vacancy in Structural or Chemical Biology at CeTPD, University of Dundee. Focus on molecular glue discovery in MND and FTD. Closing date: 6th October

www.dementiaresearcher.nihr.ac.uk/job/postdoc-...

Postdoc Research Assistant: Protein Degradation

Postdoctoral Researcher Vacancy in Structural or Chemical Biology at CeTPD, University of Dundee. Focus on molecular glue discovery in MND and FTD.

www.dementiaresearcher.nihr.ac.uk

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Dementia Researcher @dementiaresearcher.bsky.social · Jul 23

Postdoc Research Assistant in Dr Arpan Mehta’s lab at University of Dundee, using CRISPR screens in iPSC-derived motor neurons to study ALS mechanisms. Closing date: 4th August

www.dementiaresearcher.nihr.ac.uk/job/postdoc-...

Postdoc Research Assistant: Investigating C9ORF72

Postdoc Research Assistant in Dr Arpan Mehta’s lab at University of Dundee, using CRISPR screens in iPSC-derived motor neurons to study ALS mechanisms.

www.dementiaresearcher.nihr.ac.uk

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Rosie Jackson @aramblingrosie.bsky.social · Jul 22

A nice productive morning for me then…

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Reposted by Rosie Jackson

Dementia Researcher @dementiaresearcher.bsky.social · Jun 21

Join Dr Arpan Mehta's lab at MRC PPU, Dundee, for a 12-month postdoc using CRISPR screens to explore ALS in iPSC-derived motor neurons. Closing date: 18th July

www.dementiaresearcher.nihr.ac.uk/job/postdoc-...

Postdoc Research Assistant: Mechanisms of the C9ORF72

Join Dr Arpan Mehta's lab at MRC PPU, University of Dundee, for a 12-month postdoc using CRISPR screens to explore ALS in iPSC-derived motor neurons.

www.dementiaresearcher.nihr.ac.uk

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Reposted by Rosie Jackson

Claire Durrant @clairedurrant1.bsky.social · Apr 30

So excited to see our work finally out today in Nature Communications! Brilliant summary by co-first author @sorayam.bsky.social below!

Dr Soraya M @sorayam.bsky.social · Apr 30

Our paper in Nature Comms is now online! Summary below but in short we use living human brain slice cultures in a number of different ways to model dementia processes. Big team effort led by myself, @robertmcgeachan.bsky.social and @clairedurrant1.bsky.social rdcu.be/ej647

Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures

Nature Communications - Understanding synapse loss in Alzheimer’s disease has been hampered by a lack of human model systems. Here, the authors show that manipulation of physiological or...

rdcu.be

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Tara Spires-Jones 🌈🔬 @tspiresjones.bsky.social · Apr 30

Fantastic to see this work from @clairedurrant1.bsky.social group out in print! Important results using living human brain tissue to study Alzheimer’s disease www.nature.com/articles/s41...

Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures - Nature Communications

Understanding synapse loss in Alzheimer’s disease has been hampered by a lack of human model systems. Here, the authors show that manipulation of physiological or pathological Aβ has differing effects...

www.nature.com

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Rosie Jackson @aramblingrosie.bsky.social · Apr 24

Always good to head back to st Andrews to chat with undergrads about neuroscience!

Reposted by Rosie Jackson

Dementia Researcher @dementiaresearcher.bsky.social · Apr 7

Dr David Koss @davidkoss.bsky.social at University of Dundee is seeking a Postdoctoral Research Assistant to work on novel nuclear alpha-synuclein (aSyn) pathology and elevated DNA damage in Dementia with Lewy bodies. Closing date: 29th April

www.dementiaresearcher.nihr.ac.uk/job/postdoc-...

Postdoc Research Assistant: DNA damage in LBD

Dr David Koss at University of Dundee is seeking a Postdoctoral Research Assistant to work on novel nuclear alpha-synuclein (aSyn) pathology and elevated DNA damage in Dementia with Lewy bodies

www.dementiaresearcher.nihr.ac.uk

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Rosie Jackson @aramblingrosie.bsky.social · Mar 18

We love ApoE!!
Had a blast at the AAIC #APOE conference. Two whole days full of great talks, fab posters and wonderful chat with 250 of my fellow ApoE aficionados!

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Rosie Jackson @aramblingrosie.bsky.social · Mar 8

In Edinburgh and just over heard a lad say to his friend that if Scotland loses today he’s going to piss on all the daffodils he can find.
Stay classy Scotland.
#sports!

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Kira Shaw @kirasha.bsky.social · Mar 7

I am excited to have been awarded a Wellcome Trust CDA fellowship to study whether menopause enhances AD risk by exacerbating vascular dysfunction. I will be starting my lab in Manchester in January 2026, and would love to connect with other researchers interested in sex differences and AD 🧠🩸 🔬.

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Reposted by Rosie Jackson

Dementia Researcher @dementiaresearcher.bsky.social · Mar 6

Dr @aramblingrosie.bsky.social at University of Dundee is seeking x2 #PhD Students to Investigate the effects of Rare ApoE variants on protein function & structure + the Impact of ApoE source and isoform on Neuroinflammation - Closing date: 31 March

www.dementiaresearcher.nihr.ac.uk/find/jobs/?f...

Jobs in Dementia Research

Find all the latest jobs in dementia research, in the UK and across the world. Working in all areas of discovery from fundamental science, clinical research, care and social sciences.

www.dementiaresearcher.nihr.ac.uk

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Rosie Jackson @aramblingrosie.bsky.social · Mar 5

I dont think I could afford you Tal, but if you ever want a sabbatical then we have dolphins, pies, and pints!

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Rosie Jackson @aramblingrosie.bsky.social · Mar 5

Now is the moment!! If you'd like to come and do a PhD with me in sunny Dundee then I have not 1 but 2 funded PhD positions in my lab looking at #ApoE.

Please reach out with any questions!

Come do science with us, it'll be fun!

www.dundee.ac.uk/phds/opportu...

www.dundee.ac.uk/phds/opportu...

Investigating the impact of ApoE source and isoform on Neuroinflammation | University of Dundee, UK

A PhD project at the University of Dundee

www.dundee.ac.uk

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Rosie Jackson @aramblingrosie.bsky.social · Feb 24

#ARUK2025 here I come!

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Rosie Jackson @aramblingrosie.bsky.social · Feb 17

Come and talk about mental health with us Wednesday at noon GMT!

Your mental health is so so important and we all have one; it may be great, it may need nurtured, but the more we talk about it the more we understand it.

I can't promise you any answers but hopefully you'll learn you're not alone!

Dementia Researcher @dementiaresearcher.bsky.social · Feb 17

Research can be demanding, often taking a toll on mental well-being. This weeks webinar is dedicated to helping researchers navigate these pressures! Break the stigma! With @leahfullegar.bsky.social @aramblingrosie.bsky.social

communities.dementiaresearcher.nihr.ac.uk/c/events/you...

Salon - You're not alone... supporting good Mental Health

19th February, 12.00 pm GMT - Struggling with stress in academia? Join us to explore mental health support and resilience for researchers, students, and academics.

communities.dementiaresearcher.nihr.ac.uk

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Dementia Researcher @dementiaresearcher.bsky.social · Feb 2

The last of our new first time contributors is Athina Grigoriou, from the Koss Lab at University of Dundee. Working to identify a reciprocal relationship between DNA damage and neurodegeneration, specifically in synucleiopathies.

www.dementiaresearcher.nihr.ac.uk/profile-athi...

Profile – Athina Grigoriou, University of Dundee - DEMENTIA RESEARCHER

Athina Grigoriou, PhD Student at the University of Dundee working to identify a reciprocal relationship between DNA damage and neurodegeneration, specifically in synucleiopathies

www.dementiaresearcher.nihr.ac.uk

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Rosie Jackson @aramblingrosie.bsky.social · Feb 3

SO beautiful!!
Would you consider the beautiful photo of the day thing again for a little while. It was such a source of joy during covid and we might need some of that for the next wee while.

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Rosie Jackson @aramblingrosie.bsky.social · Jan 30

Replicaiton is so important because when p<0.05 that means there is a 5% chance you got your results by chance. 5% is small but its not nothing so everytime it is confirmed the confidence grows.

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Rosie Jackson @aramblingrosie.bsky.social · Jan 30

That feeling you get when you read a study that was similar (but crucially different) to yours and saw a similar result is such an amazing feeling.

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Rosie Jackson @aramblingrosie.bsky.social · Nov 29

Absolutely crucial paper showing that fixation time is important for RNAscope!

We also saw this when setting up our work and I only wish a paper like this had existed at the time so we knew where and how to focus our efforts!!!

Sarah Jäkel @sjaekel.bsky.social · Nov 29

The first paper of the Jäkel lab is out!
We have shown that the RNA detection in human FFPE brain tissue significantly changes with fixation time. Chose your tissue well before doing an experiment!

doi.org/10.1093/brai...

Impact of fixation duration on messenger RNA detectability in human formalin-fixed paraffin embedded brain tissue

Hurler et al. performed RNAScope on post-mortem human brain tissue and found mRNA signal detection to be highly dependent on fixation time. Considering the

doi.org

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Reposted by Rosie Jackson

Dementia Researcher @dementiaresearcher.bsky.social · Nov 28

If you missed this weeks webinar with tips on 'peer reviewing your first paper' you can watch the recording here:

communities.dementiaresearcher.nihr.ac.uk/c/events/pee...

Dementia Researcher Salon - Peer Reviewing your First Paper

communities.dementiaresearcher.nihr.ac.uk

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Rosie Jackson @aramblingrosie.bsky.social · Nov 27

JOin us now to hear about how to review your first paper
communities.dementiaresearcher.nihr.ac.uk/live/peer-re...

Dementia Researcher Communities

Login to Dementia Researcher Communities community via email or SSO today.

communities.dementiaresearcher.nihr.ac.uk

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Rosie Jackson @aramblingrosie.bsky.social · Nov 21

Would you be able to add me to this please.
Thanks 😀

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Rosie Jackson @aramblingrosie.bsky.social · Nov 21

Just by Tarbert, we did a quick stop on the way to Islay!

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