Short summary and the highlights of our findings: "Distinct Roles for TSLP and IL-33 in Experimental Eosinophilic Esophagitis" youtu.be/Hbic3xv38yY?... דרך
@YouTube

@EosinophilSoc

@AllergyEaaci

Short summary and the highlights of our findings: "Distinct Roles for TSLP and IL-33 in Experimental Eosinophilic Esophagitis" youtu.be/Hbic3xv38yY?... דרך
@YouTube

@EosinophilSoc

@AllergyEaaci

The study was funded by
@usisraelbsf
@IsraelAcademy
@azrielifdn
@AstraZeneca

8/8

🧬 RNA-seq analysis of esophageal tissue revealed that TSLP controls the expression of IL-13-dependent genes central to human EoE:
🧪 Eotaxins, IL-19, FLG, KLK5, IL36RN, IL1R2
📌 TSLP shapes barrier integrity, IL-1 signaling, and epithelial differentiation.
7/8

🧪 Key finding #2
IL-33 plays a more limited role.
Il33⁻/⁻ mice showed reduced eosinophilia, but no impact on tissue remodeling suggesting non-redundant roles for TSLP and IL-33 in EoE.
6/8

🧪 Key finding #1
TSLP is essential for EoE pathogenesis.
Crlf2⁻/⁻ mice were nearly completely protected from developing EoE.
Neutralizing TSLP reduced:
✅ Eosinophilia
✅ Basal cell proliferation
✅ Vascularization
✅ Lamina propria thickening
5/8

To answer this, we used genetic and antibody-based approaches in a validated mouse model of EoE (onlinelibrary.wiley.com/doi/10.1111/...).
We studied WT, Il33⁻/⁻, and Crlf2⁻/⁻ (TSLP receptor knockout) mice, and applied neutralizing antibodies to TSLP or IL-5.
4/8

Two epithelial-derived cytokines TSLP and IL-33 have been implicated in allergic diseases.
But what is their role in EoE?
And are they redundant or functionally distinct in driving this disease?
#Immunology #EoE #Eosinophils
3/8

🔬 EoE is a chronic food allergy-induced inflammation of the esophagus that is currently on the rise. It is characterized by eosinophilia, basal cell hyperplasia, and tissue remodeling. It causes swallowing difficulties, pain, and growth delay. @EosinophilSoc #Allergy
2/8

Just published in @AllergyEaaci
Led by @dsilvaanish66 in collaboration with @RothenbergLab @ChenVarol @AstraZeneca. We reveal a non-redundant and key role for TSLP in eosinophilic esophagitis (EoE)- a chronic allergic disease of the esophagus.
onlinelibrary.wiley.com/doi/10.1111/...
🧵👇
1/8

Total disgrace!

This is unacceptable. A total disgrace. Shame on the organizers. Leave science out of it! I am appalled to see this in the microbiology community 🦠

Our recent review is out!
Great working on this with
@GrisaruSharon and @BethJacobsen
www.sciencedirect.com/science/arti...

Thanks Shai

Preprint 📢📢
Epithelial cell-derived cytokines such as TSLP snd IL-33 likely have key roles in the initiation of allergic diseases. We show that despite co-upregulation/expression of IL-33 and TSLP in EoE, TSLP has a dominant role.

www.biorxiv.org/content/10.1...

Over the past few years, emerging data suggest that type 2 immune responses can have protective roles in cancer. This new review nicely summarizes recent advances in the field.
www.nature.com/articles/s41...

Mark your calendars for 22 January 2025! IES & EMBRN are coming together for a joint webinar on Single Cell Dissection of Human Mast Cells, Basophils and Eosinophils. Register now: eosinophil-society.org/webinars/jan...

In two replicate trials, depemokimab, an ultra-long-acting anti–interleukin-5 biologic therapy, reduced exacerbations in patients who had severe asthma with an eosinophilic phenotype @NEJM
www.nejm.org/doi/full/10....

Join us at the 13th Biennial Congress of the International Eosinophil Society Meeting, which will be held in Montpellier, France (July 2025). See details here:
www.eosinophil-society.org/congress/2025

We have a great program!