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arkanalabs.bsky.social
Arkana Labs
@arkanalabs.bsky.social
800 followers 760 following 720 posts
We're a center for renal & neuromuscular pathology focused on one thing: improving care for patients. #renal #pathsky #renalpath #neuropath #neuromuscular #kidneypath
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arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 22h
Here is today’s #eyeSCANdy! Spicular amyloid deposit showing blunt conical formations with interconnecting fibrils. 

Photo courtesy of Dr. Stephen Bonsib. #renal #pathology #kidneypath #pathsky #nephsky
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arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 1d
A sample from the pathology teaching slide set on Infection-related Glomerulonephritis: Schistosomal Glomerulonephritis, jointly prepared by Arkana Laboratories and @goKDIGO. http://KDIGO.org/guidelines/gd/

#KDIGO #pathology #renal #renalpath #kidneypath #nephsky #pathsky
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Reposted by Arkana Labs
juancarlosqvelez.bsky.social
Juan Carlos Q Vélez, MD @juancarlosqvelez.bsky.social · 8d
Strong signal for better kidney biopsy adequacy favoring 16G needle over 18G (w/ = complication rate) in pediatric pts 12-18 years-old, extending established norm 4 adults. Only 4 children <12, a smaller 18G needle is safer. #KidneyBiopsyAcademy @kidneycon.bsky.social @arkanalabs.bsky.social
aspneph.bsky.social
aspneph.bsky.social @aspneph.bsky.social · 8d
Adequacy and safety of pediatric native kidney biopsy using 16- and 18-gauge needles
Adequacy and safety of pediatric native kidney biopsy using 16- and 18-gauge needles - Pediatric Nephrology
Background The native kidney biopsy is an important diagnostic procedure in pediatric nephrology. Recent meta-analyses did not find the size of the needle as a risk factor for bleeding complications,…
buff.ly
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arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 1d
3/ By electron microscopy this case demonstrated numerous, randomly arranged fibrils that measured ~10 nm characteristic of amyloid fibrils within mesangial areas with extension into numerous capillary loops. Congo red stain was positive in glomeruli.
arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 1d
2/ This finding is classically seen with amyloidosis. Other glomeruli in this case demonstrated areas of PAS-weak to negative staining of mesangial areas which is another feature that should raise suspicion for possible amyloidosis.
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arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 1d
1/ The light microscopic image of a Jones silver stain shows a glomerulus with demonstrates numerous elongated, fine spicules which some regard as the "eyelash sign".

#renalpath #kidneypath #pathology #renal #pathX
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arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 1d
However, the prominent IgG deposits also involving the associated arteriole in this case are an important clue that helps argue for a secondary etiology. This patient, in fact, was found to have systemic lupus erythematosus. (2/2)

#TeachingPoints #kidneypath #renal
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arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 1d
This immunofluorescence (IF) image shows extensive granular glomerular capillary wall IgG deposits, consistent with membranous glomerulopathy. The glomerular staining pattern as seen by IF is not specific for either primary or secondary membranous glomerulopathy. (1/2)

#pathology #pathsky #nephsky
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arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 2d
Thank you to @juancarlosqvelez.bsky.social, @nephrowhitt.bsky.social, and Dr. Vandana Niyyar for joining @nephrosharma.bsky.social, and @glombandit.bsky.social for this discussion!

#Renal #kidneypath #nephrology #nephsky
Glom Goals: Why Adequacy Matters
Renal pathologists Dr. Shree Sharma and Dr. Tiff Caza sit down with nephrologists Dr. Juan Carlos Velez, Dr. Bill Whittier, and Dr. Vandana Dua Niyyar to discuss the rising renal biopsy inadequacy…
youtu.be
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arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 2d
Improving biopsy adequacy rates is essential to improving patient care.

To understand more about the renal biopsy adequacy crisis, listen to our podcast: youtu.be/GSUhu9ysNyM?...

#Renal #kidneypath #nephrology #nephsky
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arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 2d
What is your leading diagnosis when seeing this finding along the glomerular capillary loops?

#DiagnoseThis #pathology #renal #kidneypath #nephsky #pathsky
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arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 5d
The image below shows glomerular polymer emboli, seen as non-refractile, non-polarizable, basophilic foreign material (arrows) occluding the glomerular capillaries.

#kidneypath #pathology #renal #pathsky #nephsky
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arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 6d
Minimal change disease may show a subtle, finely granular, cytoplasmic IgG staining in podocytes (podocyte dusting) on immunofluorescence. This finding has been associated with podocyte injury mediated by nephrin autoantibodies.

#pathology #kidneypath #renal #pathsky #nephsky
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arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 7d
🎉 Congrats to the newest Arkana Renal Rotation Award winners! These residents earned a hands-on renal pathology experience with expert mentorship, a reference book, and support. 👏

Learn more: www.arkanalabs.com/education/re...
arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 7d
A sample from the pathology teaching slide set on Focal Segmental Glomerulosclerosis in Adults, jointly prepared by Arkana Laboratories and @goKDIGO. http://KDIGO.org/guidelines/gd/

#KDIGO #pathology #renal #renalpath #kidneypath #pathsky #nephsky
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arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 8d
Here is today’s #eyeSCANdy! Glomerular tuft with overall intact architecture. Discrete masses of specular amyloid (long arrows) interrupt smooth uninvolved segments of capillary loop (short arrows).

Photo courtesy of Dr. Stephen Bonsib. #renal #pathology #kidneypath #pathsky #nephsky
arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 8d
The answer is: C.) PCR fragment analysis of DPMK

To learn more, head to our blog: www.arkanalabs.com/ring-fibers/

#neuropath #neuromuscular #neuronotes #pathology #pathX
Ring Fibers
The images demonstrate ring fibers with fluorescence with congo red staining under polarized light. Distal muscle weakness, mild myotonia, ring fibers, and mild CK elevation are consistent with myoton...
www.arkanalabs.com
arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 8d
Overall, the biopsy in this case demonstrated a dense granulomatous tubulointerstitial nephritis which after clinical exclusion of other causes (i.e. infection, drug/hypersensitivity) were compatible with the patient's known prior history of sarcoidosis.
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arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 8d
At the end of the arrow is what is known as an asteroid body which is classically associated with sarcoidosis;
however, these are by no means specific for sarcoid as asteroid bodies have been seen in many other conditions including infections, various malignancies, foreign body granulomas, cysts,etc
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arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 8d
The light microscopic image shows a portion of a non-necrotizing granuloma comprised of
histiocytes with giant-cell formation and intermixed lymphoplasmacytic inflammation.

#renalpath #kidneypath #pathology #renal #pathsky
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arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 8d
3/ Reference: Sethi S et al. Focal and segmental glomerulosclerosis: clinical and kidney biopsy correlations. Clin Kidney J. 2014 Dec;7(6):531-7.PMID: 25503953.
arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 8d
2/For example in a patient with the nephrotic syndrome whose biopsy shows FSGS lesions and no significant immune deposits by immunofluorescence, the presence of global effacement of podocyte foot processes by electron microscopy (as seen in Fig 1) provides support for a “primary” FSGS (see ref).
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arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 8d
1/ Knowing whether a patient has clinical nephrotic syndrome and knowing the degree of podocyte foot process effacement can be helpful diagnostic clues in separating “primary” from “secondary” forms of focal segmental glomerulosclerosis (FSGS).

#TeachingPoints #kidneypath #pathology #pathsky
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arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 9d
Answer choices:
A.) PCR fragment analysis of CNBP
B.) Muscular dystrophy gene panel
C.) PCR fragment analysis of DPMK
D.) Myositis specific antibody panel

#NeuroNotes #neuropath #pathology #neuromuscularpath #neurosky #pathsky
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arkanalabs.bsky.social
Arkana Labs @arkanalabs.bsky.social · 9d
Which genetic test is required to establish the diagnosis in this 59-year-old with distal muscle weakness, mild myotonia, and persistently elevated CPK values (200-300 U/L)?

#NeuroNotes #neuropath #pathology #neuromuscularpath #neurosky #pathsky
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