Antiretroviral Therapy for Multiple Sclerosis
@art4ms.bsky.social
Rationale for Antiretroviral Therapy for Treatment of Multiple Sclerosis art4ms.com #multiplesclerosis #ms #ebv
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art4ms.com - Antiretroviral Therapy for Multiple Sclerosis
EBV drives Multiple Sclerosis. Elimination of EBV is a rational therapy for MS. The antiviral medication tenofovir alafenamide inhibits of EBV reactivation.
art4ms.com
EBV causes Multiple Sclerosis. Evidence indicating that EBV drives MS is growing. If EBV is drives MS then elimination of EBV would be a rational therapy. There are licensed drugs with activity against EBV, such as the antiviral tenofovir alafenamide. #multiplesclerosis #ms #ebv
art4ms.com
art4ms.com
There is a reduced risk of developing MS in HIV+ patients taking antiretroviral therapy. There are also several cases of patients who presented indefinite remission or resolution of multiple sclerosis symptoms after induction of ART.
#ms #ebv #multiplesclerosis
link.springer.com/article/10.1...
#ms #ebv #multiplesclerosis
link.springer.com/article/10.1...
Human immunodeficiency virus and multiple sclerosis: a review of the literature - Neurological Research and Practice
Multiple sclerosis (MS) and human immunodeficiency virus (HIV) infection are frequent and well-studied nosological entities. Yet, comorbidity of MS and HIV has only been rarely reported in the medical...
link.springer.com
January 22, 2026 at 11:58 AM
There is a reduced risk of developing MS in HIV+ patients taking antiretroviral therapy. There are also several cases of patients who presented indefinite remission or resolution of multiple sclerosis symptoms after induction of ART.
#ms #ebv #multiplesclerosis
link.springer.com/article/10.1...
#ms #ebv #multiplesclerosis
link.springer.com/article/10.1...
In the era of antiviral trials for multiple sclerosis the answer lies in the details
#ebv #ms #multiplesclerosis #art4ms #antiviral
www.dropbox.com/scl/fo/1qutc...
#ebv #ms #multiplesclerosis #art4ms #antiviral
www.dropbox.com/scl/fo/1qutc...
January 22, 2026 at 1:40 AM
In the era of antiviral trials for multiple sclerosis the answer lies in the details
#ebv #ms #multiplesclerosis #art4ms #antiviral
www.dropbox.com/scl/fo/1qutc...
#ebv #ms #multiplesclerosis #art4ms #antiviral
www.dropbox.com/scl/fo/1qutc...
Radiologic and clinical stability in an HIV-negative multiple sclerosis patient after #tenofovir: An updated case report
#MultipleSclerosis #MS #EBV
www.dropbox.com/scl/fo/1qutc...
#MultipleSclerosis #MS #EBV
www.dropbox.com/scl/fo/1qutc...
January 22, 2026 at 1:37 AM
Radiologic and clinical stability in an HIV-negative multiple sclerosis patient after #tenofovir: An updated case report
#MultipleSclerosis #MS #EBV
www.dropbox.com/scl/fo/1qutc...
#MultipleSclerosis #MS #EBV
www.dropbox.com/scl/fo/1qutc...
HIV infection and multiple sclerosis: a case with unexpected “no evidence of disease activity” status #multiplesclerosis #ms #antiviral #ebv #antiretroviral #taf #tenofovir
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
HIV infection and multiple sclerosis: a case with unexpected “no evidence of disease activity” status - Fernando Labella, Fernando Acebrón, María del Carmen Blanco-Valero, Alba Rodrígez-Martín, Ángela...
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system whose etiology remains unclear. It has been suggested that MS can...
journals.sagepub.com
January 21, 2026 at 4:43 PM
HIV infection and multiple sclerosis: a case with unexpected “no evidence of disease activity” status #multiplesclerosis #ms #antiviral #ebv #antiretroviral #taf #tenofovir
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
Tenofovir as a treatment option for multiple sclerosis
www.sciencedirect.com/science/arti...
#MS #EBV #MultipleSclerosis
www.sciencedirect.com/science/arti...
#MS #EBV #MultipleSclerosis
Tenofovir as a treatment option for multiple sclerosis
Some antiretroviral medications are also inhibitors of EBV. We describe a patient with highly active MS who was infected with HIV and started HIV-trea…
www.sciencedirect.com
January 21, 2026 at 11:50 AM
Tenofovir as a treatment option for multiple sclerosis
www.sciencedirect.com/science/arti...
#MS #EBV #MultipleSclerosis
www.sciencedirect.com/science/arti...
#MS #EBV #MultipleSclerosis
Reposted by Antiretroviral Therapy for Multiple Sclerosis
#MS_Selfie Newsletter - Necessary, but insufficient
Getting naysayers to understand and accept “EBV is necessary, but insufficient to develop MS” is important, as they often review and reject grant applications. And ..... => buff.ly/8rCPzQJ
Getting naysayers to understand and accept “EBV is necessary, but insufficient to develop MS” is important, as they often review and reject grant applications. And ..... => buff.ly/8rCPzQJ
Necessary, but insufficient
Getting naysayers to understand and accept “EBV is necessary, but insufficient to develop MS” is important, as they often review and reject grant applications. And .....
gavingiovannoni.substack.com
January 13, 2026 at 10:12 AM
#MS_Selfie Newsletter - Necessary, but insufficient
Getting naysayers to understand and accept “EBV is necessary, but insufficient to develop MS” is important, as they often review and reject grant applications. And ..... => buff.ly/8rCPzQJ
Getting naysayers to understand and accept “EBV is necessary, but insufficient to develop MS” is important, as they often review and reject grant applications. And ..... => buff.ly/8rCPzQJ
Tenofovir prodrugs potently inhibit Epstein–Barr virus lytic DNA replication by targeting the viral DNA polymerase
#EBV #MS #MultipleSclerosis #antivirals #ARTMS #ART4MS
www.pnas.org/doi/10.1073/...
#EBV #MS #MultipleSclerosis #antivirals #ARTMS #ART4MS
www.pnas.org/doi/10.1073/...
January 20, 2026 at 11:50 PM
Tenofovir prodrugs potently inhibit Epstein–Barr virus lytic DNA replication by targeting the viral DNA polymerase
#EBV #MS #MultipleSclerosis #antivirals #ARTMS #ART4MS
www.pnas.org/doi/10.1073/...
#EBV #MS #MultipleSclerosis #antivirals #ARTMS #ART4MS
www.pnas.org/doi/10.1073/...
The below chart has important implications regarding TAF dose. Fig 5G indicates that the standard dose of TAF would reach a concentration needed to block 40% of DNA replication (EC40) mediated by the EBV polymerase after 40 min in their in vitro assay.
www.pnas.org/doi/10.1073/...
#ms #ebv
www.pnas.org/doi/10.1073/...
#ms #ebv
January 20, 2026 at 11:48 PM
The below chart has important implications regarding TAF dose. Fig 5G indicates that the standard dose of TAF would reach a concentration needed to block 40% of DNA replication (EC40) mediated by the EBV polymerase after 40 min in their in vitro assay.
www.pnas.org/doi/10.1073/...
#ms #ebv
www.pnas.org/doi/10.1073/...
#ms #ebv
Tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF), are both tenofovir prodrugs that improve the absorption and delivery of tenofovir, which gets converted into its active form inside cells to stop viral replication #multiplesclerosis #ebv #ms
www.descovyhcp.com/taf-pharmaco...
www.descovyhcp.com/taf-pharmaco...
January 20, 2026 at 11:45 PM
Tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF), are both tenofovir prodrugs that improve the absorption and delivery of tenofovir, which gets converted into its active form inside cells to stop viral replication #multiplesclerosis #ebv #ms
www.descovyhcp.com/taf-pharmaco...
www.descovyhcp.com/taf-pharmaco...
Tenofovir disoproxil fumerate TDF at 300mg daily has been used for PrEP for over a decade. This may indicate that doses of tenofovir alafenamide fumerate TAF greater than 25mg are safe long term, however this needs further study. #PrEP #MultipleSclerosis #EBV
January 20, 2026 at 10:01 PM
Tenofovir disoproxil fumerate TDF at 300mg daily has been used for PrEP for over a decade. This may indicate that doses of tenofovir alafenamide fumerate TAF greater than 25mg are safe long term, however this needs further study. #PrEP #MultipleSclerosis #EBV
Below are clinical trials looking at tenofovir for treatment of Multiple Sclerosis. #EBV #antiretroviral #MS #antiviral art4ms.com
clinicaltrials.gov/study/NCT059...
mstrials.org.au/fatigue-in-r...
www.helse-bergen.no/en/neuro-sys...
clinicaltrials.gov/study/NCT059...
mstrials.org.au/fatigue-in-r...
www.helse-bergen.no/en/neuro-sys...
art4ms.com - Antiretroviral Therapy for Multiple Sclerosis
EBV drives Multiple Sclerosis. Elimination of EBV is a rational therapy for MS. The antiviral medication tenofovir alafenamide inhibits of EBV reactivation.
art4ms.com
January 20, 2026 at 9:42 PM
Below are clinical trials looking at tenofovir for treatment of Multiple Sclerosis. #EBV #antiretroviral #MS #antiviral art4ms.com
clinicaltrials.gov/study/NCT059...
mstrials.org.au/fatigue-in-r...
www.helse-bergen.no/en/neuro-sys...
clinicaltrials.gov/study/NCT059...
mstrials.org.au/fatigue-in-r...
www.helse-bergen.no/en/neuro-sys...
EBV causes Multiple Sclerosis. Evidence indicating that EBV drives MS is growing. If EBV is drives MS then elimination of EBV would be a rational therapy. There are licensed drugs with activity against EBV, such as the antiviral tenofovir alafenamide. #multiplesclerosis #ms #ebv
art4ms.com
art4ms.com
art4ms.com - Antiretroviral Therapy for Multiple Sclerosis
EBV drives Multiple Sclerosis. Elimination of EBV is a rational therapy for MS. The antiviral medication tenofovir alafenamide inhibits of EBV reactivation.
art4ms.com
January 20, 2026 at 9:27 PM
EBV causes Multiple Sclerosis. Evidence indicating that EBV drives MS is growing. If EBV is drives MS then elimination of EBV would be a rational therapy. There are licensed drugs with activity against EBV, such as the antiviral tenofovir alafenamide. #multiplesclerosis #ms #ebv
art4ms.com
art4ms.com