Targeting the somato-cognitive action network (SCAN) rather than motor regions doubles efficacy of TMS treatments for Parkinson’s disease. Seems that various DBS targets for Parkinson’s are selectively connected to the SCAN rather than effector-specific motor regions.🧪
www.nature.com/articles/s41...

The highlight of my week was the publication of "Parkinson’s disease as a somato-cognitive action network disorder" in @nature.com. It's a great paper that shows how conceptual changes in fundamental neuroscience - the discovery of SCAN - can improve treatment 🧪 www.nature.com/articles/s41...

Nature research paper: Parkinson’s disease as a somato-cognitive action network disorder

go.nature.com/4aemciV

It’s time to rethink Parkinson’s disease. Our work reframes PD as a disorder of the somato-cognitive action network (SCAN), and shows that normalizing SCAN connectivity represents a shared mechanism across diverse effective therapies.
rdcu.be/e2n4t
@ndosenbach.bsky.social @gordonneuro.bsky.social

Scientists just discovered a key brain network affected by Parkinson’s disease. The finding could change how doctors understand symptoms and lead to better treatments. 🧠 bit.ly/4qdpLMf

Parkinson's disease affects over 10 million people worldwide. A new study led by WashU Medicine researchers is paving the way for more personalized, non-invasive treatment, tackling this neurological disorder at its root. @ndosenbach.bsky.social medicine.washu.edu/news/brain-n...

I’m very excited about this new work describing the specific cortical-striatal circuits that are altered in Parkinson’s Disease and that should be targeted for optimal PD treatment.

www.nature.com/articles/s41...

My med school textbook says stimulants like Ritalin treat hyperactivity by “stimulating” the brain’s attention and cognitive control systems. We studied children taking stimulants in the ABCD Study, and the largest differences were actually in arousal and reward networks! Check out our preprint!

It turns out the brain🧠is silently🤫working when your arm is in a cast. 🩼 🚧
Plastic changes occur, and revert again when the cast is removed … not just in cortex.

It's shocking how little is known about the brainstem red nucleus. In our new paper “The human brainstem’s red nucleus was upgraded to support goal-directed action” out now in @naturecomms.bsky.social we show that current thinking on the red nucleus is in need of a serious upgrade. rdcu.be/ehbOy