EM is the culprit this time... At least it didn't also send me a new login and password (for once!)

Definitely not you Alain! My beef isn't with the timing of the request, we all need to get things done as and when we can, it's the reminder on a Sunday morning that seems tone deaf...

Surely it can't be hard to update the code to send a reminder on the n+2 work day...

Nah, probably the end of the road for us with this particular project (blame UKRI)

They even made an interactive evidence map:
research.ukhsa.gov.uk/evidence-gap...

Particularly relevant on a day when the first reports have emerged of imported Oropouche cases in the UK:
www.gov.uk/government/n...

It's a lie....🤫

Want to know more? Come to the talk by @danielacl.bsky.social today at #IHW2025 (room 2 at 11:39) or come to her poster tonight (number 3.14).

Congratulations to primary authors Holly and @danielacl.bsky.social on their first first-author research papers. This work was a fun collaboration with @deanelab.bsky.social, and many thanks to @bsfcharity.bsky.social for funding.

While pUL21 doesn’t bind a new surface on PP1, so no new antiviral drugs 😢, we have identified a new mode of PP1 binding via an extended beta sheet…this binding of a protein with no canonical SLiMs to PP1 suggests there might be many more PP1 adaptors in the cell than previously suggested.

Why would a virus keep a suboptimal RVxF motif rather than evolve higher affinity? We hypothesise that it is an additional layer of regulation, make sure that PP1 recruitment only happens in the right place, and at the right time post-infection, when local concentrations of pUL21/pORF38 are high.