Great cross-disciplinary work with @cgatist.bsky.social @sjoerdvbeentjes.bsky.social @breesheyrh.bsky.social Olivier Labayle, Kelsey Tetley-Campbell, Mark van der laan @berkeleyctml.bsky.social (n/n)

Now published: TarGene stat/ML engine doi.org/10.1093/bios...
TarGene pipeline: targene.github.io/targene-pipe...
General purpose TMLE Julia package: doi.org/10.21105/jos... (3/n)

DNA variants modulate each other’s effects, but finding interactions in population cohorts is hard due to tiny effect sizes + massive testing burden. Using TarGene on 9 nuclear hormone receptor mechanisms we uncovered 535 2-point & 185 3-point interactions, revealing sex-biased genetic risk. (2/n)

We integrate population genetics, functional genomics & targeted ML to uncover 100s of TF-linked epistatic interactions across 768 traits in UK Biobank. Epistasis, informed by mechanism, empowered by robust stat/ML, is detectable & widespread. doi.org/10.1101/2025... (1/n)

New course “EMBO Causality in Biomedicine”: We have organised the first EMBO course in *causal* stats/ML methods for quantitative biomedicine. @sjoerdvbeentjes.bsky.social @nimahejazi.org @pablormier.bsky.social @DariaSokolova @CarolineUhler

Very much looking forward to teaching and discussing!

📢 Now published:
www.embopress.org/doi/full/10.....
Since the preprint, we replicated 9 of 14 traits in All of Us & showed that #pwME with PEM-like symptoms have stronger biomarker differences.
bsky.app/profile/cgat...

📢Now published!
Know that clustering cells in reduced dimensions is problematic?
Want to identify cell subtypes or states *without* clustering?
Then check out Stator which finely resolves states & subtypes even among apparently homogeneous cells Thread
www.embopress.org/doi/full/10....

I am STOKED that myself and @avakhamseh.bsky.social are looking for a joint EastBIO PhD candidate across @uniofaberdeen.bsky.social and @uoe-sps.bsky.social to develop cutting-edge statistical models at the interface of single cell genomics and quantitative genetics: shorturl.at/vQo0P pls reskeet!