Han et al. demonstrate that binding of eIF3 to distinct sites in mRNA 5′ UTRs mediates chaperone recruitment to translating 80S ribosomes. This recruitment is essential for the correct folding of nascent ER membrane proteins, indicating that instructions for ER membrane protein folding are hardwired in the genome.

Abstract. Accurate protein synthesis requires ribosomes to integrate signals from distant functional sites and execute complex dynamics. Despite advances i

A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...

Abstract. Modifications of RNA, known as the epitranscriptome, affect gene expression, translation, and splicing in eukaryotes, with implications for devel

Ali et al. report that multiple 12q-amplified genes collaborate with AKT in sarcomagenesis, including METTL1. This oncogenic function of METTL1 is independent of its methyltransferase activity. METTL1...