Hmmm. Jasper. 😉

Consider me thoroughly jealous! I’ve been a couple of times. It’s an amazing place and always a lot of fun.

Ah, cool! Good timing, it seems! 😁 We’ve had a few along related themes (influence of solvent, pH, flow rate, etc.) for different reasons. Choice of solvents also influences observation of protonated species (in addition to radical ions).

Good that it has been useful and you didn’t lose everything over the needle position, then! On a related note, and not intended as a shameless self-plug, have you seen Mary’s paper on flow rates? Started with discussion in community about what people saw by APPI. pubs.acs.org/doi/full/10....

Oh wow! That’s a lot of work… Yup, another variable but one that is less easy to control in a repeatable manner. There’s a lot to model and some parameters are dependent on each other. 😬

Haha, yes. Not breaking the graphite ferrule is the key concern. First thing to check is the transfer line (detached) and that liquid passes through. After that, if you can see through the union. Put together, that’s 90%+ of cases. Very occasionally you will see something at the top of the ferrule.

So concentration (aggregation), avoiding particulates, use of a filter, etc. all help. As for the needle position, once set up, we don’t need to vary it and will find nebulizing gas pressure influences things. They’re interlinked. 🙂

I will check with the group which ones we currently use and then get back to you. If you don’t hear from me shortly, give me a prod. We don’t usually have too many issues with the needle itself, most issues are with the union/ferrule area.

Yup! Removing and checking the line, sonicating the union, and sometimes clearing the graphite ferrule is not a lot of fun. A filter has turned out to be a good way of reduced situations like that. 😉

Ouch! Could try modifying sample prep (extractions, etc.) or can fit a filter to your transfer line to the zero dead volume union?

And you’re well ahead of me with followers and following! Might help if I actually posted, though… 🤣

Yes, exactly that! The lack of ads and weird stuff being rammed down my throat (regardless of muting and blocking on The Other Place to try to convince the algorithm) is a big relief! I resented rubbish and an agenda being pushed all the time, regardless of what I wanted.

The numbers seem to be increasing rapidly, which was the key (temporary?) shortcoming. The app feels much faster and smoother to me, and features are advancing quickly too. Add a Community Notes equivalent and I’d say the shift will accelerate.

It feels a very different place, doesn’t it?

Welcome aboard!

“Your message has been stored in the cylindrical filing cabinet, as appropriate.”

Very true. Not many people can genuinely remember the names of all Nobel Prize winners in the past, say, 20 years. But good supervisors who nurture their group and truly look after people will be remembered. Former members will tell stories for many years, even after the supervisors have departed.

Start as you mean to go on. Sounds like a normal day already, unfortunately! 😬