Lightnews — Scholar-powered news

Reposted by Bassam Al-Fatly

Brain Communications @braincomms.bsky.social · Jul 6

Marcelino and Al-Fatly et al. report literature-based lesion network mapping of dyskinetic cerebral palsy. Grey matter lesions are the most common MRI finding; the motor thalamus is a converging node of a wide functional network. Read at buff.ly/IyRv0E0.

2 3

Reposted by Bassam Al-Fatly

Sergiu Groppa @segroppa.bsky.social · Jun 10

Take a look at our new work, providing explanations for the mechanisms of deep brain stimulation, with insights into the modulation of motor- premotor cortex activity from mouse-based and translatable research methodologies for future therapy solutions
shorturl.at/5Atjh

Frequency- and layer-specific effects of high-frequency STN stimulation on mouse motor cortical areas in vivo

Abstract. High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective evidence-based therapy for Parkinson’s disease; howe

shorturl.at

1 4 6

Reposted by Bassam Al-Fatly

Lukas Goede @lukasgoede.bsky.social · May 22

Tremor is a common symptom across many neurological disorders.

But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?

We think: yes.

Our study is out now in @natcomms.nature.com:

🔗 www.nature.com/articles/s41...

🧵 A thread.

1 14 27

Reposted by Bassam Al-Fatly

Lukas Goede @lukasgoede.bsky.social · May 22

This was a huge team effort - combining datasets across disorders, continents, and methods.

We hope this work helps advance neuromodulation toward guided, symptom-specific treatment.

Full paper: www.nature.com/articles/s41...

Convergent mapping of a tremor treatment network - Nature Communications

Goede et al. combined multiple modalities to define a common tremor network across disorders. This finding may help optimize deep brain stimulation and guide future noninvasive therapies.

www.nature.com

1 2 6

Reposted by Bassam Al-Fatly

The Science of Parkinson's @scienceofpd.bsky.social · May 23

New research from @lukasgoede.bsky.social @andreashorn.org & colleagues provides a robust, cross-condition tremor network that may guide both invasive & noninvasive neuromodulation strategies for #Parkinsons & essential tremor
www.nature.com/articles/s41...

7 12

Reposted by Bassam Al-Fatly

The Science of Parkinson's @scienceofpd.bsky.social · May 11

"Ultra-high field MRI provides high-resolution maps of various aspects of the underlying neurodegenerative process which reflect individual motor impairment in #Parkinsons" - research use 7 tesla MRI; N=43 PD & 24 controls
www.nature.com/articles/s41...

1 1

Bassam Al-Fatly @bassamalfatly.bsky.social · May 14

New insights on tremor therapeutic sweetspot and tract this time in FUS thalamotomy, congrats @andreashorn.org and team

Andreas Horn @andreashorn.org · May 14

MR guided focused ultrasound surgery is an effective and uprising treatment option for Essential tremor. But where is the optimal site to sonicate? Which spots to avoid due to side-effects?

@science.org @braincircuits.bsky.social @netstim.org

– a thread🧵!

www.science.org/doi/10.1126/...

4 7

Bassam Al-Fatly @bassamalfatly.bsky.social · May 14

would expect Kuebler and Al-Fatly coordinates in this nice figure as in Middlebrooks Fig4 ;) (www.sciencedirect.com/science/arti...)

Connectivity correlates to predict essential tremor deep brain stimulation outcome: Evidence for a common treatment pathway

Deep brain stimulation (DBS) is the most common surgical treatment for essential tremor (ET), yet there is variation in outcome and stimulation target…

www.sciencedirect.com

1

Reposted by Bassam Al-Fatly

Can Sarica @cansarica.bsky.social · May 10

movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Happy to share our work in @movedisorder.bsky.social We compared outcomes of bilateral #HIFU and #DBS in essential tremor, identified thalamic hotspots using probabilistic mapping.
@fusfoundation.bsky.social @alfonsofasano.bsky.social

4 4

Reposted by Bassam Al-Fatly

Andreas Horn @andreashorn.org · Jan 8

🚨Interested in Dystonia?🚨
@braincircuits.bsky.social

GPi DBS for dystonia is effective.

More recently, STN DBS has been investigated, as an alternative.

In what enfolded like a stunning thriller to me, Konstantin Butenko tells a tale of two networks…

www.pnas.org/doi/10.1073/...

2 25 49

Reposted by Bassam Al-Fatly

Michael Fox @foxmdphd.bsky.social · Jan 8

Do we need to stimulate different circuits to improve different dystonia symptoms with STN DBS? Work by Konstantin Butenko, @andreashorn.org @braincircuits.bsky.social out today in @PNAS says yes:
Engaging dystonia networks with subthalamic stimulation | PNAS www.pnas.org/doi/10.1073/...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

15 22

Reposted by Bassam Al-Fatly

Bratislav Misic @misicbata.bsky.social · Dec 19

Mapping neuropeptide signaling in the human brain | doi.org/10.1101/2024...

Neuropeptides are among the functionally diverse signaling molecules in the brain and body.

@cebric.bsky.social curates an atlas of neuropeptide receptors and relates it brain function 🧩 🧠 ⤵️

3 39 90

Reposted by Bassam Al-Fatly

Andreas Horn @andreashorn.org · Dec 16

Is it critical to stimulate @ndosenbach.bsky.social's SCAN and CON networks for clinical improvements of Tourette's patients that undergo DBS?

Carlos Baldermann says yes in a cool new paper out in @natureportfolio.bsky.social comms today!

www.nature.com/articles/s41...

1 15 35

Reposted by Bassam Al-Fatly

Michael Okun @michaelokun.bsky.social · Dec 17

Do you know the actual tic networks in Gilles de la Tourette Syndrome? Juan Carlos Baldermann and a whole host of colleagues explore this in a new article in Nature Communications. Dosenbach and Gordon sparked this group to action after the DBSThinkTank.

1 5 16

Reposted by Bassam Al-Fatly

The Science of Parkinson's @scienceofpd.bsky.social · Nov 28

New paper finds that aberrant relative brain hyperperfusion (amount of blood flowing to the brain), independent of striatal dopamine depletion, is associated with baseline & longitudinal motor deficits & progression of neurodegeneration in #Parkinsons
www.neurology.org/doi/10.1212/...

Association of Relative Brain Hyperperfusion Independent of Dopamine Depletion With Motor Dysfunction in Patients With Parkinson Disease | Neurology

Background and ObjectivesParkinson disease (PD) exhibits a characteristic pattern of brain perfusion or metabolism, thereby being considered network disorder. Using dual-phase N-(3-fluoropropyl)-2β-ca...

www.neurology.org

4 13

Reposted by Bassam Al-Fatly

The Science of Parkinson's @scienceofpd.bsky.social · Nov 24

Analysis of 39 cases of focused ultrasound subthalamotomy for #Parkinsons highlights the functional anatomy of the subthalamic nucleus & the pathophysiology of cardinal features of PD; Reduced bradykinesia & rigidity associated with ablation of rostral motor STN
www.science.org/doi/10.1126/...

2 3

Bassam Al-Fatly @bassamalfatly.bsky.social · Nov 28

Our paper entitled “Neuroimaging-based analysis of DBS outcomes in pediatric dystonia: insights from the GEPESTIM registry” is now out in Neuroimage Clinical

sciencedirect.com/science/articl…

1

Bassam Al-Fatly @bassamalfatly.bsky.social · Nov 28

It is a pleasure to be in #BrainStimConf to present this new study and very happy to have been awarded a travel grant by #IBROTavelGrant Many thanks to #IBRO and my coauthors @andreashorn_ @AA_Kuhn @foxmdphd @MichaelOkun and many others not on Twitter #Neurology

3

Bassam Al-Fatly @bassamalfatly.bsky.social · Nov 28

Happy to have passed the European Board of Neurology 2022 Exam, I recommend it to all #Neurology fellows, many thanks to @EANeurology for the organizing and giving this opportunity to have in depth knowledge in neurology, have to say a bit tough but doable 😃

1

Bassam Al-Fatly @bassamalfatly.bsky.social · Nov 28

Nice overview from @HSiebner on targeting brain circuitry using personalized noninvasive brain stimulation approaches @Retune_CRC

Bassam Al-Fatly @bassamalfatly.bsky.social · Nov 28

Lesions in the tremor circuit can induce tremor (1st img), similar lesions can treat an "existing" tremor (2nd img) -In this case, DBS/lesioning surgery require a pre-existing pathological oscillation to work, can DBS still enhance functionality in normal brain?

Bassam Al-Fatly @bassamalfatly.bsky.social · Nov 28

Very happy about this successful multicenter "european" collaboration spearheaded by Andreas Nowacki & Sabry Barlatey on mapping beneficial effect of DBS in Essential Tremor in 119 pts @andreashorn_ @DembekTill @AA_Kuhn @VVV_Cologne @leaddbs @netstim_org

onlinelibrary.wiley.com/doi/10.1002/an…

Probabilistic Mapping Reveals Optimal Stimulation Site in Essential Tremor

Objective The objective of this study was to obtain individual clinical and neuroimaging data of patients undergoing deep brain stimulation (DBS) for essential tremor (ET) from 5 different European ...

onlinelibrary.wiley.com

Bassam Al-Fatly @bassamalfatly.bsky.social · Nov 28

Excited to share our new study about mapping beneficial effect of STN-DBS on Quality of Life in PD thanks to Günther Deuschl for this amazing opportunity together with Inken Tödt & @andreashorn_, read more in threads🔽

…mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…

The Contribution of Subthalamic Nucleus Deep Brain Stimulation to the Improvement in Motor Functions and Quality of Life

Background Subthalamic nucleus deep brain stimulation (STN-DBS) effectively treats motor symptoms and quality of life (QoL) of advanced and fluctuating early Parkinson's disease. Little is known abo...

movementdisorders.onlinelibrary.wiley.com

Bassam Al-Fatly @bassamalfatly.bsky.social · Nov 28

Lesion and dbs network mapping of tics, a very fruitful first coauthorship with the one and only @ChristosGanos, amazingly supervised by @AA_Kuhn and @andreashorn_ and a great multicenter collaboration and with @foxmdphd (the pioneer of lesion network mapping), such an honor

t.co/5iqCBjnXvk

Bassam Al-Fatly @bassamalfatly.bsky.social · Nov 28

#FSL users,
any hint on how to use #FSL topup on two phase encoded #DTI scans each with 63 directions and 1 b0, the data is actually from PPMI dataset (PD patients) and am trying to correct for susceptibility distortion using topup. Thanx #neuroimaging #neuroscience

1