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Reposted by Benedetta Bolognesi

Kalli Kappel @kallikappel.bsky.social · Jun 17

In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput approach to measure nuclear condensate formation, and applied it to ~14,000 IDPs to find out!

rdcu.be/eq975

Characterizing protein sequence determinants of nuclear condensates by high-throughput pooled imaging with CondenSeq

Nature Methods - CondenSeq is an imaging-based, high-throughput platform for characterizing condensate formation within the nuclear environment, uncovering the protein sequence features that...

rdcu.be

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Benedetta Bolognesi @bennibolo.bsky.social · Jun 12

Our lab @ibecbarcelona.eu is hiring both 👩‍💻 and 🧪 profiles (or mixed!) to mechanistically probe disordered and aggregation prone proteins at scale using combinatorial strategies. Get in touch!

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Benedetta Bolognesi @bennibolo.bsky.social · Jun 12

This one is close to my ❤️ as we learnt SO MUCH in the process. We hope this approach will be employed to address the transition states 🎇 of many other reactions - amyloid and not! Well done @immunobananna.bsky.social, Mireia and @ajfaure.bsky.social!

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Benedetta Bolognesi @bennibolo.bsky.social · Jun 12

New cocktail 🍹 in town - in collaboration with @benlehner.bsky.social : Massive combinatorial mutagenesis + amyloid kinetics selection + thermodynamic modelling showing us the portrait 🎨 of an amyloid transition state. Read about it in this great thread:

Anna Arutyunyan @immunobananna.bsky.social · Jun 12

Alzheimer’s disease 🧠starts with a molecular domino effect - but what triggers the first piece to fall?
In our new study we cracked open the black box of early protein aggregation, and the findings could reshape how we fight neurodegeneration. 🧵👇

www.science.org/doi/10.1126/...

Massively parallel genetic perturbation suggests the energetic structure of an amyloid-β transition state

The aggregation rates of >140,000 mutants reveal the energetic structure of an amyloid-β nucleation reaction transition state.

www.science.org

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Danielle Beckman @daniellebeckman.bsky.social · Jun 5

A black hole in the early universe? Sometimes I like to imagine that I operate a telescope, not a microscope 😁. The hole in the middle of the image is actually a blood vessel. The stars are astrocytes🟡 in the human brain, interacting with beta-amyloid🔵. The brain is from a donor with #Alzheimer.

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Benedetta Bolognesi @bennibolo.bsky.social · Jun 4

Candle-lit commuting sponsored by @rodalies.info 🕯️🕯️🕯️

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John Burn-Murdoch @jburnmurdoch.ft.com · Jun 4

Full slide deck here from our talk yesterday on the gender divide and relationship recession, featuring many more countries and plenty of economic data too: www.dropbox.com/scl/fi/1lp1d...

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Ed Yong @edyong209.bsky.social · May 30

I urge everyone to read Unbreaking’s new page on everything the govt is doing to destroy & diminish medical research funding.

It’s the best thing I’ve read on this topic: @lizneeley.bsky.social & co have such done an incredible job.

unbreaking.org/issues/medic...

Medical Research Funding — Unbreaking

How the administration is breaking the government, and what that means for all of us.

unbreaking.org

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Benedetta Bolognesi @bennibolo.bsky.social · May 23

And what a great talk to end #VariantEffect25 ! Thanks to the amazing crowd that travelled to Barcelona and made MSS25 such a fantastic meeting. Lots to think about now! 🧦🗺️☀️

Jonathan Frazer @jonnyfrazer.bsky.social · May 23

And now, the final talk of #VariantEffect25. @roseorenbuch-art.bsky.social from Harvard Medical School presents work from our long-standing collaboration, and one that’s very close to my heart: Proteome-wide model for human disease genetics

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Benedetta Bolognesi @bennibolo.bsky.social · May 22

Fantastic talk #VariantEffect25 by @pollyfordyce.bsky.social on how much we can understand about sequence-function relationships once we are able to factor in kinetic 🏎️rates. Microfluidics 💧💧for the win!

Jonathan Frazer @jonnyfrazer.bsky.social · May 22

Next up at #VariantEffect25: @pollyfordyce.bsky.social presents: Microfluidics for quantitative and high-throughput biophysics and biochemistry 💧

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Isabelle Zane @isabellease.bsky.social · May 22

@pollyfordyce.bsky.social at #VariantEffect25

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Jonathan Frazer @jonnyfrazer.bsky.social · May 21

Good views, food and even better company at #VariantEffect25

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IBEC | Institute for Bioengineering of Catalonia @ibecbarcelona.eu · May 21

The first poster session just started! #VariantEffect25

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Jonathan Frazer @jonnyfrazer.bsky.social · May 21

Welcome back from the lunch break. Kicking off the afternoon session at #VariantEffect25 we welcome Patrick Hsu @pdhsu.bsky.social all the way from @arcinstitute.org – Bridging biology and AI for genome design 💥🧬🤖 #SynBio #AI Let’s gooo! 🚀

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Jonathan Frazer @jonnyfrazer.bsky.social · May 21

It is a deeply inspiring story, reminding us why we do what we do.

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Jonathan Frazer @jonnyfrazer.bsky.social · May 20

Welcome back from the coffee break and to the last session of Workshop 1 of #VariantEffect25. @pascalnotin.bsky.social is giving us an overview of protein fitness prediction models! #AI #ProteinML

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Jonathan Frazer @jonnyfrazer.bsky.social · May 20

Next up at #VariantEffect25 Workshop 1 we have Noelia Ferruz! From Rosetta to Flow Matching: The Evolution of Protein Design -How Should You Begin Today?

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Jonathan Frazer @jonnyfrazer.bsky.social · May 20

Let’s get this party started! Kicking off workshop 1 of #VariantEffect25 we have Albert Escobedo — From Fitness to Free Energy: Thermodynamic Modeling of Protein DMS Data for Accurate Genetic Prediction with MoCHI 🍡🧬

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Doug Fowler @dougfowler.bsky.social · May 15

Our "Atlas of Variant Effects 2030 Roadmap" is live: zenodo.org/records/1542...

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Atlas of Variant Effects 2030 Roadmap: resolving human variants of uncertain significance

At the Clinical Atlas of Variant Effects meeting (CLAVE meeting, July 2024, Pittsburgh USA), we developed recommendations for a draft atlas that can be realized by 2030, with a focus on empowering gen...

zenodo.org

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Jamison Foser @jamisonfoser.bsky.social · May 14

there are 1,100 words in this article and zero of them are "bus"

TechCrunch @techcrunch.com · May 14

Uber to introduce fixed-route shuttles in major US cities designed for commuters

Uber to introduce fixed-route shuttles in major US cities designed for commuters | TechCrunch

Ride-hail and delivery giant Uber is introducing cheap, fixed-route rides along busy corridors during weekday commute hours in major U.S. cities -- one

techcrunch.com

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Benedetta Bolognesi @bennibolo.bsky.social · May 9

@marianomartin.bsky.social discussing amyloid formation from random sequence extensions at our first CNS 🧠network event @ibecbarcelona.eu
Find out more this week on @pnas.org!

www.pnas.org/doi/10.1073/...

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Benedetta Bolognesi @bennibolo.bsky.social · May 9

Countdown officially started! #VariantEffect25 @varianteffect.bsky.social

Jonathan Frazer @jonnyfrazer.bsky.social · May 8

Very nice blogpost from @pascalnotin.bsky.social. You can catch him in Barcelona at www.varianteffect.org/mss2025/ #VariantEffect25 in a couple of weeks if you want to chat! Also, watch this space -- hoping to continue this discussion soon!

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IBEC | Institute for Bioengineering of Catalonia @ibecbarcelona.eu · May 2

CAT
1/ 🧵 Una IA catalana desxifra el llenguatge secret de les proteïnes "enganxoses"

CANYA, desenvolupada pel @crg.eu i l’ #IBEC, pot predir quan i per què es formen agregats proteics, un procés relacionat amb malalties com l’Alzheimer 👇

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Benedetta Bolognesi @bennibolo.bsky.social · Apr 28

Blackout pipetting @ibecbarcelona.eu

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IBEC | Institute for Bioengineering of Catalonia @ibecbarcelona.eu · Apr 8

🏆 Congrats to #IBEC researcher Dr. Irene Marco-Rius on winning the 2025 Anatole Abragam Prize! 🎉

Her groundbreaking work in hyperpolarized #MRI & organ-on-a-chip tech is transforming disease diagnosis & therapy monitoring. 🔬👏

#MagneticResonance #ScienceExcellence #ISMARENC2025

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