Jan Berghöfer
@berghoefer.bsky.social
Computational Biologist | PhD student @molgen.mpg.de | Genomics, epigenetics, gene regulation | he/him
Across RNA-seq and proteomics, we see recurring signals: ECM organisation, haem and NET biology, platelet activation, and PI3K–AKT/MAPK pathways.
Sixteen proteins shift across all contrasts.
Sixteen proteins shift across all contrasts.
December 2, 2025 at 2:01 PM
Across RNA-seq and proteomics, we see recurring signals: ECM organisation, haem and NET biology, platelet activation, and PI3K–AKT/MAPK pathways.
Sixteen proteins shift across all contrasts.
Sixteen proteins shift across all contrasts.
By linking ROHs, homozygous variants, ATAC peaks and Hi-C contacts, we identify regulatory variants near loci such as PLAG1 and SDR16C5. These align with known body-size biology without implying causality.
December 2, 2025 at 2:01 PM
By linking ROHs, homozygous variants, ATAC peaks and Hi-C contacts, we identify regulatory variants near loci such as PLAG1 and SDR16C5. These align with known body-size biology without implying causality.
ROH mapping revealed strong but largely breed-specific selection footprints in Aachen Minipigs and Mini-LEWE.
These regions guided our search for functional regulatory variants.
These regions guided our search for functional regulatory variants.
December 2, 2025 at 2:01 PM
ROH mapping revealed strong but largely breed-specific selection footprints in Aachen Minipigs and Mini-LEWE.
These regions guided our search for functional regulatory variants.
These regions guided our search for functional regulatory variants.
Phenotypically, miniature and larger-sized pigs share the same growth plate architecture, but differ quantitatively.
Absolute zone lengths and chondrocyte nuclei are smaller in miniature breeds, pointing to quantitative modulation of shared programmes rather than a reorganisation of the plate.
Absolute zone lengths and chondrocyte nuclei are smaller in miniature breeds, pointing to quantitative modulation of shared programmes rather than a reorganisation of the plate.
December 2, 2025 at 2:01 PM
Phenotypically, miniature and larger-sized pigs share the same growth plate architecture, but differ quantitatively.
Absolute zone lengths and chondrocyte nuclei are smaller in miniature breeds, pointing to quantitative modulation of shared programmes rather than a reorganisation of the plate.
Absolute zone lengths and chondrocyte nuclei are smaller in miniature breeds, pointing to quantitative modulation of shared programmes rather than a reorganisation of the plate.