Seminar time⏲️ We welcome Professor Dimitrios Fotiadis, IBMM, Medical Faculty, University of Bern: “Structural and mechanistic insights into transmembrane glucose transport and light-driven proton pumping” 🥳More info: ccemmp.org/events/ccemm...

Join our Cryo-ET workshop and learn sample preparation, grid screening and data collection.
📍Ian Holmes Imaging Centre
🗓️9th-10th September 2025
🔗Register now: rduevents.unimelb.edu.au/event/2271-c...
#CryoET #ElectronMicroscopy #StructuralBiology #CCeMMP

Many in the #Crystallography community will remember this (and may have helped put part of it together). Our record breaking diamond structure built at the 2023 IUCr congress in Melbourne
[Photo credit Jun Aishima]

Congratulations Javaid!

Cryo-EM was conducted at Ian Holmes Imaging Centre at, with data collected by Hamish Brown, with contributions from
@bio21director.bsky.social , @bigfrenchman.bsky.social
, Michelle Christie, Riya Joesph, Craig Morton and Rod Tweten and team. #cryoEM

This work was part of my PhD at UniMelb and was my first foray into cryo-EM! Admittedly, learning the various steps of cryo-EM on proteoliposome samples felt like jumping in the deep end so I am very happy and proud for all to see how it worked out.

These structures reveal how multiple regulatory features, such as proteolytic activation, ensure pore formation. Furthermore, we find features that are not common to the related CDC family of pore-forming toxins. Instead, CDCLs seem show features that straddle the CDC, MACPF and gasdermin families.

This includes the crystal structure of the proteolytically-activated form and cryo-EM structures of the inserted pore and prepore-like complex, solved on the surface of liposomes.

Excited to share that our work on a family of pore-forming proteins is now live in Science Advances! We show structural snapshots across the entire pore-forming pathway for a cholesterol-dependent cytolysin-like (CDCL) bicomponent system.

Our paper on the structure and evolution of baculovirus is out! Excited to share work I did at Monash in the Coulibaly lab, with big shout outs to co-authors Josh and Jungmin, collaborators Mart and team and everyone else who contributed. Definitely one of the coolest structures I'll ever work on 🤩