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This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.

Abstract. Metatranscriptome sequencing dramatically expanded the known diversity of the global RNA virome and, in particular, suggested several new candida

Proximity-ligation-based sequencing from 111 samples and 5 environments reveals that a substantial proportion of phages infect multiple species.

Rodrigues and Queiroz et al. report the discovery of Naiavirus, the largest enveloped virus, isolated from a Brazil biome. With an oval capsid and flexible tail, its giant genome holds many novel gene...

Ants, as highly eusocial insects, play vital roles in ecosystems worldwide. While numerous RNA viruses have been documented in ants, no double-stranded DNA (dsDNA) virus has previously been confirmed to infect them. Labial gland disease, reported for decades, lacks a clearly defined cause until now. Here, we identify and characterize a large filamentous dsDNA virus, Camponotus japonicus labial gland disease virus (CjLGDV), from the swollen labial gland of C. japonicus, and a closely related Anoplolepis gracilipes labial gland disease virus in A. gracilipes. Phylogenetic and genomic analyses of the two viruses support the establishment of a new viral family within the order Lefavirales, class Naldaviricetes. The discovery of endogenous viral elements related to CjLGDV in multiple ant genomes suggests the historical infection of CjLGDV-like viruses in ants. These findings broaden the known host range of naldaviricetes and shed new light on the diversity, evolution, and host interaction of large dsDNA viruses in arthropods.

Bacteria and archaea possess an enormous variety of antivirus immune systems that often share homologous proteins and domains, some of which contribute to diverse defense strategies. YprA family helic...

The virus-host arms race is a major component of the evolutionary process in all organisms that drove the evolution of a broad variety of immune mechanisms. In the last few years, over 200 distinct an...

Establishing antisense oligomers as versatile, non-genetic tools to silence phage mRNAs opens applications in basic research and biotechnology, as shown by identifying essential factors for propagatio...

Nature Communications - Orsay virus establishes a latent infection in C. elegans, triggering age-dependent immunity and RNAi based cross-protection that limits secondary infections and reveals...

Journal of General Virology ICTV Virus Taxonomy Profiles are a freely available series of concise, review-type articles that provide overviews of the classification, structure and properties of indivi...

The realm Duplodnaviria includes viruses of archaea, bacteria and eukaryotes, with linear dsDNA genomes. Duplodnavirians share a distinct morphogenetic module of four hallmark genes encoding the HK97-...

Bacterial defense systems present considerable barriers to both phage infection and plasmid transformation. These systems target mobile genetic elements, limiting the efficacy of bacteriophage-based t...

Programmable DNA integration using CRISPR-associated transposons (CASTs) offers powerful capabilities for genome engineering. The single effector Cas12k CAST examples evolved from a fixed guide TnpB n...

This Perspective discusses virus-encoded auxiliary metabolic genes and provides a framework for the biological interpretation of these genes.