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Reposted by Thibaut Brunet

Christophe 🔬 L @christlet.bsky.social · 23h

I might be in a lot of pain rn but on the bright side I finally got my hands on the Haeckel tee-shirt

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Reposted by Thibaut Brunet

Institut Jacques Monod @ijmonod.bsky.social · 23h

📢 Institut Jacques Monod Lecture

📅 October 17th
📍 IJM

Next week, Bruno Lemaitre, will present the Institut Jacques Monod lecture « A retrospective analysis of 400 publications reveals patterns of irreproducibility across an entire life sciences research field »

➡️ buff.ly/qqCVgL9

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Reposted by Thibaut Brunet

Thibaut Brunet @thibautbrunet.bsky.social · 5d

Latest from ours: www.cell.com/cell-reports...

This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵

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Levayer Lab @levayerr.bsky.social · 1d

Happy to share the last version of our story @currentbiology.bsky.social on the role of interfacial tension in mechanical cell competition led by @leovalon.bsky.social and Alexis Matamoro Vidal
www.sciencedirect.com/science/arti...

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Iana V. Kim @ianakim.bsky.social · 2d

Really grateful to see our work featured by @quantamagazine.bsky.social in this piece on the evolution of genome regulation. Huge thanks to @philipcball.bsky.social for such a beautifully written article.

Philip Ball @philipcball.bsky.social · 2d

I adored writing this piece. It brings together several of the things preoccupying me right now, like chromatin organization and gene regulation. There's so much more to be said on that. Also, these marine critters look gorgeous.
www.quantamagazine.org/loops-of-dna...

Loops of DNA Equipped Ancient Life To Become Complex | Quanta Magazine

New work shows that physical folding of the genome to control genes located far away may have been an early evolutionary development.

www.quantamagazine.org

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Nat Clarke @natclarke.bsky.social · 2d

🚨 My lab is hiring at all levels!

Interested in animal origins & evolutionary cell biology?

I'm recruiting a postdoc, PhD students & a research assistant to study the molecular evolution of cell adhesion using marine invertebrates + comparative genomics.

🔗: clarkelab.com/join/

Please repost!

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Alex de Mendoza @alexdemendoza.bsky.social · 2d

Thrilled to share that the lab has been awarded a @wellcometrust.bsky.social Discovery Award to keep exploring the evolution of 6-methyladenine #6mA in Eukaryotes. We'll open postdoc (3️⃣) and tech (1️⃣) positions to start in 2026, please share with candidates or reach out if you’d like to join us.

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Sally Warring @sallywarring.bsky.social · 4d

A new preprint from us using a single-cell genome pipeline to investigate diversity of uncultured Bodo spp. flagellates.

We isolated 7 Bodo spp. cells from a single environmental sample and show that they represent 3 Bodo sp. each with a unique species of bacterial endosymbiont. #protistsonsky

Single-cell sequencing reveals unexpected genetic diversity among Bodo spp. flagellates and their bacterial endosymbionts

Bodo is a cosmopolitan genus of free living bacterivorous single-celled flagellates in the class Kinetoplastea. Members of genus Bodo are considered the closest free-living relatives to the parasitic ...

www.biorxiv.org

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Reposted by Thibaut Brunet

Institut Pasteur | 130 years of biomedical research @pasteur.fr · 2d

Pour chaque vie, la science agit.
Le Pasteurdon, c’est maintenant !
Soutenez la recherche et celles et ceux qui la font avancer ↘️ pasteurdon.fr
#Pasteurdon

Pour chaque vie, la science agit. Le Pasteurdon, c’est maintenant ! Soutenez la recherche et celles et ceux qui la font avancer. Faites un don sur pasteurdon.fr

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Thibaut Brunet @thibautbrunet.bsky.social · 3d

Join us!

EMBO @embo.org · 3d

Learn all things #cytoskeleton #research in an interdisciplinary environment at EMBO Workshop "Structure and Function of the Cytoskeleton" in Paris, FR, 7–10 April 2026.

Deadline: 20 December 2025

https://meetings.embo.org/event/26-cytoskeleton
#EMBOCytoskeletalFunction #EMBOevents #conference 🧪

Structure and Function of the Cytoskeleton

The cytoskeleton, a dynamic and intricate network of protein filaments, is found within the cytoplasm of all cells, from bacteria and archaea to complex eukaryotes. This essential cellular component …

meetings.embo.org

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Reposted by Thibaut Brunet

EMBO @embo.org · 3d

Learn all things #cytoskeleton #research in an interdisciplinary environment at EMBO Workshop "Structure and Function of the Cytoskeleton" in Paris, FR, 7–10 April 2026.

Deadline: 20 December 2025

https://meetings.embo.org/event/26-cytoskeleton
#EMBOCytoskeletalFunction #EMBOevents #conference 🧪

Structure and Function of the Cytoskeleton

The cytoskeleton, a dynamic and intricate network of protein filaments, is found within the cytoplasm of all cells, from bacteria and archaea to complex eukaryotes. This essential cellular component …

meetings.embo.org

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Thibaut Brunet @thibautbrunet.bsky.social · 3d

Great opportunity to do bioimage analysis in an exceptional environment!

Jean-Yves Tinevez @jytinevez.bsky.social · 3d

Job alert!

We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?

See also on the forum:
forum.image.sc/t/research-e...

Research engineer in Bioimage Analysis for the researchers of the inIdEx FORMULA

Hi all We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks? The position is in the Instit...

forum.image.sc

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Thibaut Brunet @thibautbrunet.bsky.social · 3d

Thanks Adrien! actually we haven't yet tested mechanosensing in this paper (but stay tuned).

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Reposted by Thibaut Brunet

Ben Engel @cellarchlab.com · 10d

EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬

The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩‍🔬🤓

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Reposted by Thibaut Brunet

Thomas Lecuit @thomaslecuit.bsky.social · 4d

Pleasure to announce the program of my new series of lectures at the College de France in Nov-Dec. Continuing on the theme of Biological information. I will focus on the computational aspects, building on David Marr's tri-level of analysis in biological systems. YouTube link sent when it starts.

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Thibaut Brunet @thibautbrunet.bsky.social · 4d

Thanks Max!

Reposted by Thibaut Brunet

Gaspar Jekely @jekely.biologists.social.ap.brid.gy · 5d

Postdoc position in regenerative biology on "Tracking the cellular origins regeneration" in the @michalis_averof lab in Lyon, France. Fantastic lab, great institute, nice city!
https://www.averof-lab.org/pages/tracman

#postdoc

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Reposted by Thibaut Brunet

Katrina Velle @katrinavelle.bsky.social · 5d

PhD or Master's position available for Fall 2026!

Interested in how actin drives cell crawling, eating, dividing, or osmoregulation? What about pathogenesis of a brain-eating amoeba? Or eukaryotic evolution? If so, apply through my website: katrinavelle.wixsite.com/science/cont...
Please share!

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Reposted by Thibaut Brunet

James Gahan @jgahan.bsky.social · 5d

Amazing work by @thibautbrunet.bsky.social and his lab! I can’t stress enough how significant a development this is for Choanoflagellate research and it has been revolutionary for our work!

Thibaut Brunet @thibautbrunet.bsky.social · 5d

Latest from ours: www.cell.com/cell-reports...

This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵

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Thibaut Brunet @thibautbrunet.bsky.social · 5d

Thanks James - the pipeline has been transformative for us too. I must say thank god for biorXiv, through which we could share it early and proceed with long revision experiments (from which came most insights on Hippo) without feeling like we were withholding a protocol from the community...

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Thibaut Brunet @thibautbrunet.bsky.social · 5d

oops, one day I'll manage to remember this hashtag

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Thibaut Brunet @thibautbrunet.bsky.social · 5d

Thanks Prof. Dudin! 🙏

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Thibaut Brunet @thibautbrunet.bsky.social · 5d

Thanks for sticking until the end, and for more insights (notably on different knock-out techniques and on the risk posed by unexpected alternative start codons...), check out the paper: www.cell.com/cell-reports... 🙏

A selection-based knockout approach for a choanoflagellate reveals regulation of multicellular development by Hippo signaling

Combredet et al. report a robust and fast gene-knockout method for the choanoflagellate Salpingoeca rosetta, one of the closest relatives of animals. Inactivation of genes encoding homologs of compone...

www.cell.com

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Thibaut Brunet @thibautbrunet.bsky.social · 5d

Together, this suggests that Hippo/YAP might have already controlled both contractility and ECM secretion before animals evolved. Animals plugged in one additional output: proliferation. Under this hypothesis, the best-known function of YAP would have been the latest innovation.

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Thibaut Brunet @thibautbrunet.bsky.social · 5d

Conservation might extend even further: DJ Pan's lab had shown that YAP helps multicellular colonies resist flattening by gravity in yet another relative of animals (the filopodiated amoeba Capsaspora) by making cells more contractile -a function also present in zebrafish tinyurl.com/323jmdht

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