Rencontre avec Pierrick Coupé qui nous parle de sa dernière étude : l’arbre de vie du cerveau (lifespan tree of brain anatomy), pour le diagnostic différentiel simultané de plusieurs maladies neurodégénératives.

Introduction Quantification of amyloid plaques (A), neurofibrillary tangles (T2), and neurodegeneration (N) using PET and MRI is critical for Alzheimer’s disease (AD) diagnosis and prognosis. Existing pipelines face limitations regarding processing time, tracer variability handling, and multimodal integration. Methods We developed petBrain, a novel end-to-end processing pipeline for amyloid-PET, tau-PET, and structural MRI. It leverages deep learning-based segmentation, standardized biomarker quantification (Centiloid, CenTauR, HAVAs), and simultaneous estimation of A, T2, and N biomarkers. It is implemented in a web-based format, requiring no local computational infrastructure and software usage knowledge. Results petBrain provides reliable, rapid quantification with results comparable to existing pipelines for A and T2, showing strong concordance with data processed in ADNI databases. The staging and quantification of A/T2/N by petBrain demonstrated good agreements with CSF/plasma biomarkers, clinical status and cognitive performance. Discussion petBrain represents a powerful open platform for standardized AD biomarker analysis, facilitating clinical research applications.

The lifespan tree of brain anatomy improves multiclass differential diagnosis of neurodegenerative diseases by modeling brain volume changes over time. It outperforms SVM, provides interpretable dise...

L’atrophie multi-systématisée est une pathologie neurodégénérative rare, proche de la maladie de Parkinson. Quels sont les signes cliniques ? Comment la diagnostiquer et la prendre en charge ? Le point avec le Pr Wassilios Meissner, chef du service de neurologie des maladies neurodégénératives au CHU de Bordeaux, et coordinateur national du centre de référence de l’AMS.

Using brain charts that map structural changes in the brain across the human lifespan, Planche et al. estimate the neurodegenerative trajectories of the th