Brain
@brain1878.bsky.social
Brain has published landmark papers in clinical neurology and translational neuroscience since 1878.
Reposted by Brain
To commemorate the bicentenary of Jean-Martin Charcot's life. Without him Neurology would be a different speciality.
@uclqsion.bsky.social @brain1878.bsky.social @masudhusain.bsky.social
academic.oup.com/brain/articl...
@uclqsion.bsky.social @brain1878.bsky.social @masudhusain.bsky.social
academic.oup.com/brain/articl...
Charcot redux
Jean-Martin Charcot was born in Paris on 29 November 1825. To mark the bicentenary of his birth, the International Society for the History of the Neuroscie
academic.oup.com
November 19, 2025 at 9:41 AM
To commemorate the bicentenary of Jean-Martin Charcot's life. Without him Neurology would be a different speciality.
@uclqsion.bsky.social @brain1878.bsky.social @masudhusain.bsky.social
academic.oup.com/brain/articl...
@uclqsion.bsky.social @brain1878.bsky.social @masudhusain.bsky.social
academic.oup.com/brain/articl...
Cortical cerebral microinfarcts spark cognitive decline
New scientific commentary by Gemma Solé-Guardia, Anil Tuladhar & Frank-Erik de Leeuw: tinyurl.com/nhrr7fek
New scientific commentary by Gemma Solé-Guardia, Anil Tuladhar & Frank-Erik de Leeuw: tinyurl.com/nhrr7fek
November 17, 2025 at 9:42 PM
Cortical cerebral microinfarcts spark cognitive decline
New scientific commentary by Gemma Solé-Guardia, Anil Tuladhar & Frank-Erik de Leeuw: tinyurl.com/nhrr7fek
New scientific commentary by Gemma Solé-Guardia, Anil Tuladhar & Frank-Erik de Leeuw: tinyurl.com/nhrr7fek
Reposted by Brain
Are you familiar with immunoglobulin G’s pathophysiological role in fibromyalgia? Check out Israel et al.’s article in @brain1878.bsky.social, and Allan Basbaum’s comment on his view of this paper to find out! bit.ly/47B1fii #PRF
November 17, 2025 at 1:00 PM
Are you familiar with immunoglobulin G’s pathophysiological role in fibromyalgia? Check out Israel et al.’s article in @brain1878.bsky.social, and Allan Basbaum’s comment on his view of this paper to find out! bit.ly/47B1fii #PRF
Choo et al. show that damage to the medial temporal lobe – particularly the hippocampus – reduces the precision of memory for fine visual details, underscoring the role of this region in maintaining the fidelity of visual working memory representations. tinyurl.com/t2jxztz7
November 10, 2025 at 1:56 PM
Choo et al. show that damage to the medial temporal lobe – particularly the hippocampus – reduces the precision of memory for fine visual details, underscoring the role of this region in maintaining the fidelity of visual working memory representations. tinyurl.com/t2jxztz7
November's issue of Brain is now online! academic.oup.com/brain/issue/...
November 5, 2025 at 1:00 PM
November's issue of Brain is now online! academic.oup.com/brain/issue/...
Mukherjee et al. review how ageing affects remyelination in MS. While most studies suggest remyelination capacity decreases with age, findings are sometimes inconsistent, and remyelination remains possible at any age. tinyurl.com/c2ynpfrj
October 22, 2025 at 7:27 PM
Mukherjee et al. review how ageing affects remyelination in MS. While most studies suggest remyelination capacity decreases with age, findings are sometimes inconsistent, and remyelination remains possible at any age. tinyurl.com/c2ynpfrj
Togo et al. show strong electrophysiological links between the hippocampus and both the anterior and posterior thalamus, along with robust connections between thalamic subregions. tinyurl.com/5c6n23xj
October 22, 2025 at 7:26 PM
Togo et al. show strong electrophysiological links between the hippocampus and both the anterior and posterior thalamus, along with robust connections between thalamic subregions. tinyurl.com/5c6n23xj
Kollenburg et al. review the molecular mechanisms and regional activity patterns underlying headache disorders including migraine, cluster headache, and paroxysmal hemicrania. tinyurl.com/46aafjxu
October 13, 2025 at 7:56 PM
Kollenburg et al. review the molecular mechanisms and regional activity patterns underlying headache disorders including migraine, cluster headache, and paroxysmal hemicrania. tinyurl.com/46aafjxu
Reposted by Brain
The current environment is making it near impossible to run clinical trials in the UK.
One key issue discussed in @brain1878.bsky.social
is the duplication - or worse - of regulatory oversight at NHS hospitals & universities.
My views on how to change the system
academic.oup.com/brain/articl...
One key issue discussed in @brain1878.bsky.social
is the duplication - or worse - of regulatory oversight at NHS hospitals & universities.
My views on how to change the system
academic.oup.com/brain/articl...
October 6, 2025 at 6:07 AM
The current environment is making it near impossible to run clinical trials in the UK.
One key issue discussed in @brain1878.bsky.social
is the duplication - or worse - of regulatory oversight at NHS hospitals & universities.
My views on how to change the system
academic.oup.com/brain/articl...
One key issue discussed in @brain1878.bsky.social
is the duplication - or worse - of regulatory oversight at NHS hospitals & universities.
My views on how to change the system
academic.oup.com/brain/articl...
Pruckner et al. show that the structural effects of neurosurgery extend beyond the resected tissue into connected networks through transneuronal degeneration. They were able to reliably predict these changes from preoperative MRI. tinyurl.com/a6rxvbey
October 7, 2025 at 9:21 AM
Pruckner et al. show that the structural effects of neurosurgery extend beyond the resected tissue into connected networks through transneuronal degeneration. They were able to reliably predict these changes from preoperative MRI. tinyurl.com/a6rxvbey
New issue of Brain now online! tinyurl.com/mwxp6x24
October 4, 2025 at 7:19 PM
New issue of Brain now online! tinyurl.com/mwxp6x24
Avalos-Alais et al. present a high-resolution probabilistic map of bidirectional effective connectivity between the human lateral PFC and widespread cortical and subcortical regions, based on analysis of intracranial evoked potentials. tinyurl.com/br7htec9
October 3, 2025 at 8:35 AM
Avalos-Alais et al. present a high-resolution probabilistic map of bidirectional effective connectivity between the human lateral PFC and widespread cortical and subcortical regions, based on analysis of intracranial evoked potentials. tinyurl.com/br7htec9
Mongay-Ochoa et al. review advanced methods for mapping brain connections and identify common topographical patterns of pathology spread across different neurological disorders, including MS, AD and PD. tinyurl.com/3sz8ayup
September 19, 2025 at 8:33 PM
Mongay-Ochoa et al. review advanced methods for mapping brain connections and identify common topographical patterns of pathology spread across different neurological disorders, including MS, AD and PD. tinyurl.com/3sz8ayup
Research into mental imagery often relies on Hume’s view of visual imagination as weak perception. Arcangeli & Bartolomeo argue that Sartre’s alternative framework – supported by recent findings on aphantasia – offers a more conceptually robust approach. tinyurl.com/n2k3md9e
September 17, 2025 at 7:41 PM
Research into mental imagery often relies on Hume’s view of visual imagination as weak perception. Arcangeli & Bartolomeo argue that Sartre’s alternative framework – supported by recent findings on aphantasia – offers a more conceptually robust approach. tinyurl.com/n2k3md9e
Pansieri et al. argue that bureaucracy is suffocating research, as an ever increasing admin burden consumes researchers’ time and diverts focus from discovery to compliance. tinyurl.com/ybv5e9ft
September 13, 2025 at 2:44 PM
Pansieri et al. argue that bureaucracy is suffocating research, as an ever increasing admin burden consumes researchers’ time and diverts focus from discovery to compliance. tinyurl.com/ybv5e9ft
Using tau PET and post-mortem data from individuals with five clinical variants of AD, de Bruin et al. show that tau progression follows the brain’s intrinsic functional connectivity architecture, originating from local epicentres. tinyurl.com/bdfprjcn
September 8, 2025 at 11:34 AM
Using tau PET and post-mortem data from individuals with five clinical variants of AD, de Bruin et al. show that tau progression follows the brain’s intrinsic functional connectivity architecture, originating from local epicentres. tinyurl.com/bdfprjcn
Reposted by Brain
Excited to see our paper on the CD5 signalling pathway in Th17 cells and its role in #MultipleSclerosis out in @brain1878.bsky.social today. Thanks to everyone involved in this great team work! @neurologymainz.bsky.social @toszkabohn.bsky.social #ImmunoSky
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
Role of CD5 signalling for pro-inflammatory Th17 response in multiple sclerosis
Pape et al. link the CD5-CK2-STAT3 signalling pathway to both inflammation and effector function in multiple sclerosis, using a multi-modal approach that c
academic.oup.com
August 26, 2025 at 5:43 PM
Excited to see our paper on the CD5 signalling pathway in Th17 cells and its role in #MultipleSclerosis out in @brain1878.bsky.social today. Thanks to everyone involved in this great team work! @neurologymainz.bsky.social @toszkabohn.bsky.social #ImmunoSky
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
September's issue of Brain is now online! academic.oup.com/brain/issue/...
September 3, 2025 at 11:16 AM
September's issue of Brain is now online! academic.oup.com/brain/issue/...
Abreaction was once a common treatment for functional neurological disorder (FND) but has since fallen out of use. Norman Poole argues that abreaction is compatible with many findings from modern neuroscience, and should be tested as a treatment for FND. tinyurl.com/fcjpywx2
August 29, 2025 at 9:48 AM
Abreaction was once a common treatment for functional neurological disorder (FND) but has since fallen out of use. Norman Poole argues that abreaction is compatible with many findings from modern neuroscience, and should be tested as a treatment for FND. tinyurl.com/fcjpywx2
Reposted by Brain
Super stoked to share our paper just out in Brain @brain1878.bsky.social
LoF variants in DENND2B give rise to an autosomal dominant neurodevelopmental condition characterized by developmental delay, intellectual disability, and episodes of psychosis and/or catatonia. tinyurl.com/4k8hr3bj
LoF variants in DENND2B give rise to an autosomal dominant neurodevelopmental condition characterized by developmental delay, intellectual disability, and episodes of psychosis and/or catatonia. tinyurl.com/4k8hr3bj
Variants in DENND2B are associated with vulnerability for neurodevelopmental impairment, psychosis and catatonia
Murthy et al. report that monoallelic loss of function variants in the DENND2B gene give rise to an autosomal dominant neurodevelopmental disorder characte
tinyurl.com
August 12, 2025 at 6:45 PM
Super stoked to share our paper just out in Brain @brain1878.bsky.social
LoF variants in DENND2B give rise to an autosomal dominant neurodevelopmental condition characterized by developmental delay, intellectual disability, and episodes of psychosis and/or catatonia. tinyurl.com/4k8hr3bj
LoF variants in DENND2B give rise to an autosomal dominant neurodevelopmental condition characterized by developmental delay, intellectual disability, and episodes of psychosis and/or catatonia. tinyurl.com/4k8hr3bj
From signal to senescence: IFNγ drives muscle atrophy in myositis
New scientific commentary by Werner Stenzel et al. tinyurl.com/33hwhd8f
New scientific commentary by Werner Stenzel et al. tinyurl.com/33hwhd8f
August 11, 2025 at 8:22 PM
From signal to senescence: IFNγ drives muscle atrophy in myositis
New scientific commentary by Werner Stenzel et al. tinyurl.com/33hwhd8f
New scientific commentary by Werner Stenzel et al. tinyurl.com/33hwhd8f
Arena et al. show that a history of TBI or repetitive head impacts from contact sports is associated with widespread tau pathology within glial cells, beyond that of chronic traumatic encephalopathy. tinyurl.com/h658b3f2
August 8, 2025 at 7:57 PM
Arena et al. show that a history of TBI or repetitive head impacts from contact sports is associated with widespread tau pathology within glial cells, beyond that of chronic traumatic encephalopathy. tinyurl.com/h658b3f2
August's issue of Brain is now online! academic.oup.com/brain/issue/...
August 4, 2025 at 10:20 AM
August's issue of Brain is now online! academic.oup.com/brain/issue/...
Yogeshwar et al. present clinical and MRI data from 127 patients with anti-IgLON5 disease. They show brain atrophy patterns that closely mirror sites of autoantibody binding and tau accumulation, with the location of atrophy linked to specific symptoms. tinyurl.com/3u4ufv2z
July 28, 2025 at 2:56 PM
Yogeshwar et al. present clinical and MRI data from 127 patients with anti-IgLON5 disease. They show brain atrophy patterns that closely mirror sites of autoantibody binding and tau accumulation, with the location of atrophy linked to specific symptoms. tinyurl.com/3u4ufv2z
Peruzzotti-Jametti et al. examine the remyelination potential of mouse- and human-derived directly induced neural stem cell (iNSC) grafts, and show that iNSCs can differentiate into mature oligodendrocytes and remyelinate axons in demyelinated lesions. tinyurl.com/3a2auah5
July 22, 2025 at 10:06 AM
Peruzzotti-Jametti et al. examine the remyelination potential of mouse- and human-derived directly induced neural stem cell (iNSC) grafts, and show that iNSCs can differentiate into mature oligodendrocytes and remyelinate axons in demyelinated lesions. tinyurl.com/3a2auah5