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Bou-Nader lab

@bounaderlab.bsky.social

120 followers 130 following 20 posts

Our team studies #Rloop & #RNA 🧬 with #biochemistry #cryoEM 🔬❄️ #crystallography💎 to understand how they control life! Views from Charles https://biochem.emory.edu/bou-nader-lab/

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Bou-Nader lab @bounaderlab.bsky.social · Jun 11

Happy to share the news I've received the Beckman Young Investigator award 🥳 This recognizes the pioneering work done by my mentees to push the barriers of understanding and manipulating #R-loop biology 🧬 grateful for their hard work and for this recognition

Beckman Foundation @beckman-foundation.bsky.social · Jun 10

Congratulations to our 2025 Beckman Young Investigator Awardees! Ten researchers to receive $6M in total science #funding for cutting-edge #research: www.beckman-foundation.org/latest-news/...
#BYI #beckman #science #grants #academia #chemistry #lifesciences

Beckman Foundation Announces 2025 Beckman Young Investigator Awardees

Beckman Foundation announces 2025 Beckman Young Investigator Awardees - 10 researchers selected to receive $6M in total science funding for cutting-edge research. #BYI

www.beckman-foundation.org

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Bou-Nader lab @bounaderlab.bsky.social · 16h

Congrats Jason! Well deserved 🎉

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Kevin K. Yang 楊凱筌 @kevinkaichuang.bsky.social · 6d

Test the activity of 300+ natural enzymes against 100+ substrates, discover 200+ new enzymatic reactions, and train machine learning models to predict which enzymes can do which reactions.

@aepaton.bsky.social @gabegomes.bsky.social @alisonnarayan.bsky.social

www.nature.com/articles/s41...

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CortésLab @corteslab.bsky.social · 5d

Kickstarting our Bluesky🦋 account with great news!
Our REPAIRome study finally out today in
@science.org
www.science.org/doi/10.1126/...

A comprehensive genetic catalog of human double-strand break repair

The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) w...

www.science.org

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Dirk Remus @dirkremus.bsky.social · 9d

Great work from Michelle Wang’s group at Cornell exploring how RNAP II and associated R-loops act as intrinsic roadblocks during mechanical DNA unzipping. These findings have mechanistic implications for transcription–replication conflict.

rdcu.be/eILVd

RNA polymerase II is a polar roadblock to a progressing DNA fork

Nature Communications - Transcription–replication conflicts can threaten genome stability. Here, the authors show that RNA polymerase II (Pol II) is a stronger roadblock to a DNA fork in the...

rdcu.be

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Hopfner Lab @hopfnerlab.bsky.social · 20d

Thrilled that our work is now finally out in Nature Comms!
rdcu.be/eG3vP

We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!

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Ed Twomey @cryoet.bsky.social · 22d

🚨🧠🔬 A major breakthrough in molecular neuroscience:

I am excited to share a new story from our lab, published in accelerated format today by @nature.com:

"Delta-type glutamate receptors are ligand-gated ion channels"

Read more here (free article link): rdcu.be/eGIKz

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Bou-Nader lab @bounaderlab.bsky.social · 22d

Congrats Alexander and team 🎉 starting strong 💪

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Alexander Price @pricelesssci.bsky.social · 22d

Very excited to share the first publication from the Price Lab, "Replication-competent adenovirus reporters utilizing endogenous viral expression architecture", is now online at Journal of Virology!
journals.asm.org/doi/10.1128/...

Replication-competent adenovirus reporters utilizing endogenous viral expression architecture | Journal of Virology

This research provides powerful new tools to rapidly study adenovirus gene expression and replication. By integrating fluorescent and secreted luciferase reporters into native viral regulatory element...

journals.asm.org

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Oli Clarke @olibclarke.bsky.social · 26d

This one is a bit of a departure from the usual and definitely a work in progress!

We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.

Read on for details... 1/x

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David Bartel's Lab @bartellab.bsky.social · 28d

Check out the latest work from Jordan Ray (@jordanray.bsky.social), a collaboration between our lab and David Sabatini’s lab. www.biorxiv.org/content/10.1... (1/2)

Lysosomal RNA profiling reveals targeting of specific types of RNAs for degradation

Autophagy targets a wide variety of substrates for degradation within lysosomes. While lysosomes are known to possess RNase activity, the role of lysosomal RNA degradation in post-transcriptional gene...

www.biorxiv.org

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siddhartha jena @epijenatics.bsky.social · 27d

Excited to share my postdoc work, out on bioRxiv today! Histones package DNA into nucleosomes to form the building blocks of chromatin, but how modular and programmable is this system? 1/9

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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 27d

Another tour-de-force from David Baker's lab : custom DNA-binding miniproteins to target specific DNA sequences for diverse applications in gene regulation and editing.

With David, nothing is impossible !

Nature Structural & Molecular Biology @natsmb.nature.com · 27d

New online: Computational design of sequence-specific DNA-binding proteins

Computational design of sequence-specific DNA-binding proteins

Nature Structural & Molecular Biology, Published online: 12 September 2025; doi:10.1038/s41594-025-01669-4The authors develop a computational method to design small DNA-binding proteins (DBPs) that target specific sequences. Designed DBPs show structural accuracy and function in both bacterial and mammalian cells for transcriptional regulation.

go.nature.com

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Bou-Nader lab @bounaderlab.bsky.social · Sep 6

Congrats Bret and team 🎉

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Bret Freudenthal @freudlab.bsky.social · Sep 5

Thrilled to share our lab’s latest work in JBC! 🎉 We uncovered a critical role for APE1 Asn174 in stabilizing AP-sites using mutagenesis, enzymology, crystallography, and MD-simulations. Congrats to Kaitlin Dehart and all the co-authors! Check it out: www.jbc.org/article/S002...

APE1 active site residue Asn174 stabilizes the AP-site and is essential for catalysis

Apurinic/Apyrimidinic (AP)-sites are common and highly mutagenic DNA lesions that can arise spontaneously or as intermediates during Base Excision Repair (BER). The enzyme apurinic/apyrimidinic endonu...

www.jbc.org

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Bou-Nader lab @bounaderlab.bsky.social · Sep 4

Big congrats Martin 🎉

Bou-Nader lab @bounaderlab.bsky.social · Sep 4

Congrats Jeanine and all 🎉 cool work!

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Jeanine Gezelle @jgezelle.bsky.social · Sep 2

Our study from the Steckelberg lab is out now in @narjournal.bsky.social !! We dove into a new nuclease-blocking viral #RNA structure important for viral infection, which provided evidence of similar structure-based strategies across diverse viral families. academic.oup.com/nar/article/...

A conserved viral RNA fold enables nuclease resistance across kingdoms of life

Abstract. Viral exoribonuclease-resistant RNA (xrRNA) structures block cellular nucleases to produce subgenomic viral RNAs during infection. High sequence

academic.oup.com

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Lucas Farnung @lucas.farnunglab.com · Aug 29

🧬 Transcription elongation by RNA polymerase II relies on a web of elongation factors. Our new work shows how IWS1 acts as a modular scaffold to stabilize & stimulate elongation. Fantastic work by Della Syau! www.biorxiv.org/content/10.1...

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Bou-Nader lab @bounaderlab.bsky.social · Aug 27

Fantastic work Ahmad and team 🎉 congrats to all!

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Ahmad Jomaa @jomaalab.bsky.social · Aug 26

Want to know how lipidation of some nascent chains takes place by NMT2-- Check our latest work on how NAC couples Protein Synthesis with Nascent Polypeptide Myristoylation on the Ribosome out today @embojournal.org‬: www.embopress.org/doi/full/10....

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Bou-Nader lab @bounaderlab.bsky.social · Aug 23

Big congrats Niladri! Great things ahead and gd luck with the start 🍀

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Duxin lab @duxinlab.bsky.social · Aug 22

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it".

During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.

Read our review and find out why and how: doi.org/10.1016/j.ti...

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Eugene Valkov @eugenevalkov.bsky.social · Aug 13

Delighted to present our second paper of the year. This one explores the molecular mechanism of TTP, a key post-transcriptional regulator of AU-rich mRNAs. Work led and coordinated by @filippekovic.bsky.social, in collaboration with Perry Blackshear.

www.nature.com/articles/s41...

Multivalent interactions with CCR4–NOT and PABPC1 determine mRNA repression efficiency by tristetraprolin - Nature Communications

Deadenylation leads to mRNA decay, with PABPC1 protecting the poly(A) tail, while tristetraprolin and CCR4–NOT promote deadenylation. Here, the authors describe how these three proteins interact to re...

www.nature.com

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Luijsterburglab @luijsterburglab.bsky.social · Aug 5

Dive into the step-by-step choreography of transcription-coupled DNA repair.

In our new review published in Nature Cell Biology, we explore what we know and what’s next in this exciting field of research!

www.nature.com/articles/s41...

The molecular basis of human transcription-coupled DNA repair - Nature Cell Biology

This Review discusses transcription-coupled DNA repair in response to the stalling of RNA polymerase II on different types of DNA lesions and highlights the molecular details for the different steps i...

www.nature.com

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Bou-Nader lab @bounaderlab.bsky.social · Aug 2

Wonderful! Congrats Ahmad and team 🎉

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