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braincase.bsky.social
Brain Case
@braincase.bsky.social
49 followers 48 following 170 posts
Specializes in neuroscience, focusing on virus vector research and translational research.Follow us on www.ebraincase.com
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Brain Case @braincase.bsky.social · Sep 26
🎉 LIVE at CNS 2025 Xi’an!
Visit Booth T9 to play our fun game, win exclusive Brain Case gifts 🐱✨, and grab the 2025 Neuroscience Frontier Handbook!

📅 Sept 25–28 | Xi’an International Convention & Exhibition Center
www.ebraincase.com/news/corpora...

#CNS2025 #CNSXiAn #Neuroscience #BrainScience
braincase.bsky.social
🧠Client Article | #Neuron🎉
A new study reveals a tumor–metabolite–neuron axis in pancreatic #cancer. Tumor-derived SAM and METTL14-mediated m⁶A modification drive LPBN neural hyperexcitability and pain–depression comorbidity
🧪 #ViralTools used in this work from us
www.ebraincase.com/support/cust...
Client Article | Neuron | Prof. Jingdun Xie’s Team at Sun Yat-sen University Decodes PDAC Comorbidity: How the Tumor–Metabolism–Neuron Axis Drives Pain and Depression
This study reveals how tumor-derived SAM and METTL14-driven m⁶A modification rewire LPBN neural circuits to drive pain–depression comorbidity in PDAC.
www.ebraincase.com
December 16, 2025 at 3:29 AM
braincase.bsky.social
🎥 New Explainer Video: How to Choose the Right Green Calcium Imaging Tool?
From GCaMP6 to jGCaMP7, jGCaMP8, and the latest soma-targeted RiboL1-jGCaMP8—this video breaks down AP sensitivity, kinetics, brightness, and the best applications for each indicator.
👉 youtu.be/Y2Nu0yJrN0g?...

#Neuroscience
🎥 New Explainer Video: How to Choose the Right Green Calcium Imaging Tool?
YouTube video by Brain Case 布林凯斯
youtu.be
December 12, 2025 at 6:29 AM
braincase.bsky.social
📡🤩Ultimate GCaMP Comparison⚡
GCaMP6 → jGCaMP7 → jGCaMP8 → RiboL1-jGCaMP8
We benchmark sensitivity, kinetics, soma targeting & RO-injection brightness to identify the best GECIs for each experimental need.
www.ebraincase.com/support/lite...

#GCaMP #GECI #Neuroscience #CalciumImaging #NeuralActivity
How to Choose the Right Green Calcium Imaging Tool? From GCaMP6 to jGCaMP8 — This Guide Explains Everything You Need!
A complete guide comparing GCaMP6, jGCaMP7, jGCaMP8 and RiboL1-jGCaMP8, covering sensitivity, kinetics, soma targeting and RO-injection brightness performance.
www.ebraincase.com
December 11, 2025 at 7:26 AM
braincase.bsky.social
Tissue clearing unlocks organ-scale, single-cell 3D imaging without sectioning. Learn key clearing methods and applications in neural and immune circuit mapping. Brain Case Biotech provides reliable, end-to-end clearing services. 👉 www.ebraincase.com/support/lite...

#Neuroscience #TissueClearing
In-Depth Interpretation | Tissue Clearing Technologies: A 3D Imaging Tool for Neuroscience
Learn how hydrophobic, hydrophilic, and hydrogel-based tissue clearing enable organ-scale 3D imaging, transforming neural circuit mapping and disease research.
www.ebraincase.com
December 9, 2025 at 2:18 AM
braincase.bsky.social
✨AAV Critical Quality Attributes (CQAs) Explained🤩
AAV quality drives gene therapy safety & efficacy. This review breaks down the 5 key CQAs—identity, titer & potency, purity, impurities, and safety.

Read More👉: www.ebraincase.com/support/lite...

#GeneTherapy #AAV #Biotech #ViralVector #CQA
In-Depth Analysis of Critical Quality Attributes (CQAs) for AAV
Explore the critical quality attributes (CQA) of AAV vectors, including identity, potency, purity, impurities, and safety, for safe and effective gene therapy.
www.ebraincase.com
December 5, 2025 at 8:38 AM
braincase.bsky.social
Red–green lactate sensors (R-iLACCO1.2 + eLACCO2.1) enable real-time, no-blind-spot imaging of intracellular production, organelle shuttling,and extracellular release.A powerful tool for studying neuroenergetics, ANLS, and tumor metabolism
👉 www.ebraincase.com/support/lite...

#Neuroscience #sensor
Literature Interpretation | “Red–Green Sensors” Enable Seamless, Full-Spectrum Visualization of L-Lactate Metabolic Dynamics
A breakthrough red–green dual-sensor system enables high-resolution, minimally invasive in vivo imaging of L-lactate dynamics in awake mice, revealing metabolic–neuronal coupling.
www.ebraincase.com
December 3, 2025 at 2:04 AM
braincase.bsky.social
⚡Literature Review | Breakthrough! R-eLACCO2.1 enables awake-mouse cortical imaging, capturing extracellular L-lactate dynamics and neuronal activity simultaneously.

🔗 Original: www.nature.com/articles/s41...
👉 Insights: www.ebraincase.com/support/lite...

#ReLACCO #LactateSensor #LactateImaging
A red fluorescent genetically encoded biosensor for in vivo imaging of extracellular l-lactate dynamics - Nature Communications
l-lactate is a key metabolite supporting neuronal activity, but methods to monitor l-lactate dynamics alongside neuronal activity in vivo have been limited. Here, authors report R-eLACCO2.1, a red flu...
www.nature.com
December 1, 2025 at 7:01 AM
braincase.bsky.social
🧬Customer Research !
How do rodents choose their insect prey? A new study reveals that linoleic acid (LA) attracts mice while (Z)-9-tricosene triggers avoidance, regulated by the VTA–mOT dopaminergic pathway. D1 neurons drive attraction, and D2 mediate aversion
🔗 www.ebraincase.com/support/cust...
Customer Research Highlight | PNAS | Yunfeng Zhang, Yiqun Yu, and Minghong Ma Teams Reveal How the VTA–mOT Dopaminergic Pathway Regulates Odor-Guided Insect Predation in Mice
A PNAS study reveals how linoleic acid and (Z)-9-tricosene, detected via the main olfactory system, interact with the VTA–mOT dopaminergic pathway to regulate rodent insect predation.
www.ebraincase.com
November 28, 2025 at 1:39 AM
braincase.bsky.social
🧬 AAV not expressing?
🔍 Weak fluorescence?
Here’s your step-by-step guide to fixing the most common AAV pitfalls—from titer and serotype to detection and sample processing.
www.ebraincase.com/support/lite...

#AAV #AAVVector #ViralVectors #GeneDelivery #GeneExpression #NeuroscienceResearch
Cracking the AAV Expression Problem: No Signal? Weak Fluorescence? Here’s Your Step-by-Step Fix from Virus to Detection
Learn how to solve AAV expression loss and weak fluorescence with step-by-step optimization of vector design, viral titer, injection dose, timing, detection, and sample processing.
www.ebraincase.com
November 25, 2025 at 8:23 AM
braincase.bsky.social
🧠Year-End Research Sale 2025 is live | Nov 24–Dec 7
🧬 AAV In-Stock:
1→20% OFF
3→30% OFF
5→40% OFF
🧪Combo Pack $589: 6×20 µL viral vectors (1 new)
🎁Mystery Box $199
🧫Neurotropic Virus Series: 20% OFF
🔬Custom Packaging: Up to 40% OFF
View full promo list & details www.ebraincase.com/news/corpora...
🧠 Year-End Research Sale 2025 : A Unified Thanksgiving–Black Friday–Cyber Monday Promotion✨
Holiday research sale featuring AAVs, PRV/HSV/RV/VSV tools, combo packs, mystery boxes, and custom virus packaging discounts. Nov 24–Dec 7.
www.ebraincase.com
November 24, 2025 at 2:06 AM
braincase.bsky.social
🧠 ear-End Research Sale 2025 is live|Nov 24–Dec 7
🧬AAV In-Stock: 1→20% OFF
3 →30% OFF
5 →40% OFF
🧪Combo Pack $589: 6×20 µL viral vectors (1 new)
🎁Mystery Box $199
🧫Neurotropic Virus Series: 20% OFF
🔬Custom Packaging: Up to 40% OFF
View full promo list & details: www.ebraincase.com/news/corpora...
🧠 Year-End Research Sale 2025 : A Unified Thanksgiving–Black Friday–Cyber Monday Promotion✨
Holiday research sale featuring AAVs, PRV/HSV/RV/VSV tools, combo packs, mystery boxes, and custom virus packaging discounts. Nov 24–Dec 7.
www.ebraincase.com
November 24, 2025 at 2:04 AM
braincase.bsky.social
🧬Tongji University developed thoracic spinal cord organoids (enTsOrg) using iPSCs, LDH, and Matrigel, enabling motor function recovery in an SCI mouse model. Brain Case Biotech is honored to have provided the viral vector tools.
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#Neuroscience #Organoids #BrainCase
November 20, 2025 at 8:32 AM
braincase.bsky.social
🧬 Literature Highlight
eLACCO2.1 and R-iLACCO enable high-sensitivity, dual-color monitoring of extracellular and intracellular L-lactate in neurons, astrocytes, glioblastoma, and live mice—advancing neural and tumor metabolism research.

🔗👉 www.ebraincase.com/support/lite...

#Neuroscience #Lactate
Literature Highlight | “Red–Green Sensors” Enable Full-Field, Dynamic Visualization of L-Lactate Metabolism
These probes enable spectrally and spatially multiplexed imaging of extracellular and intracellular L-lactate in cultured cells (e.g., HeLa cells, neurons), brain slices, and live mice.
www.ebraincase.com
November 17, 2025 at 7:11 AM
braincase.bsky.social
🎉Customer Article
A new study from Prof. Jingning Zhu’s team reveals that RVMM H4R activates TRPV1-linked GABAergic neurons to suppress sympathetic activity, lowering blood pressure.This work identifies H4R as a promising central target for neurogenic hypertension
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Client Publication | Adv. Sci. | Nanjing University Team Led by Prof. Jingning Zhu Uncovers a Novel Medulla H4R-Mediated Mechanism for Blood Pressure Reduction—A Potential New Target for Hypertension ...
Optogenetic study shows H4R excites RVMM GABAergic neurons via TRPV1, suppressing sympathetic activity and lowering blood pressure.
www.ebraincase.com
November 14, 2025 at 2:12 AM
braincase.bsky.social
🧠Precision Gene Delivery to Brain Vessels: rAAV-miniBEND
Developed by teams led by Woo-ping Ge&Wenzhi Sun,this AAV system enables efficient, specific gene delivery to brain endothelial cells and rapid modeling of cerebrovascular malformations
🔗 www.ebraincase.com/news/new-pro...

#AAV #GeneDelivery
Nat Biomed Eng | Woo-ping Ge and Wenzhi Sun’s teams develop the rAAV-miniBEND system: Breaking through the challenge of brain endothelial cell gene delivery and enabling cerebrovascular malformation m...
rAAV-miniBEND: Gene delivery to brain endothelial cells and modeling of vascular malformation diseases.
www.ebraincase.com
November 12, 2025 at 1:00 AM
Reposted by Brain Case
piatkevich.bsky.social
AAVs are crucial vectors for delivering biosensors into neurons! Using AAV delivery, we perform two-color imaging of calcium and potassium transients in neurons. These AAVs are now available from @braincase.bsky.social www.ebraincase.com/news/new-pro...
November 6, 2025 at 10:15 AM
braincase.bsky.social
🔥The world’s first red fluorescent potassium sensors — RGEPO1 & RGEPO2 — are here!
Developed by Kiryl D. Piatkevich’s team at Westlake University, these sensors enable real-time in vivo imaging of potassium ions
🔗 www.ebraincase.com/news/new-pro...

#Neuroscience #RGEPO #PotassiumImaging #NeuroTech
The world’s first red fluorescent potassium sensors,RGEPO1/2,are here! |A new tool for deciphering neurological diseases—with expert commentary from Prof. Yulong Li’s team at Peking University,reveali...
RGEPO1/2—Developed by Kiryl D. Piatkevich’s team at Westlake Laboratory/Westlake University, these sensors enable real-time in vivo imaging of potassium ions.
www.ebraincase.com
November 6, 2025 at 2:13 AM
braincase.bsky.social
🧬 Precision Gene Delivery to Brain Blood Vessels 🧠
The Woo-ping Ge Lab developed rAAV-miniBEND, a targeted AAV system for efficient, cell-specific gene delivery to brain endothelial cells—advancing cerebrovascular disease modeling.
👉 www.nature.com/articles/s41...

#GeneDelivery #AAV #Neuroscience
A targeted vector for brain endothelial cell gene delivery and cerebrovascular malformation modelling - Nature Biomedical Engineering
A recombinant adeno-associated virus system for restricted gene expression in brain endothelial cells enables cerebrovascular disease modelling.
www.nature.com
November 5, 2025 at 8:39 AM
braincase.bsky.social
✨🧠Client Publication|CRH Neurons Protect Against Acute Lung Injury
A study by Xiangya Second Hospital,published in Nature Communications,reveals that PVN CRH neurons protect against ALI via the sympathetic–neutrophil axis through β₂-AR/β-arrestin2–NF-κB signaling
🔗 www.ebraincase.com/support/cust...
Client Publication | Nature Communications | Xiangya Second Hospital team led by Dr. Ruping Dai and Dr. Hui Li reveals the hypothalamic paraventricular nucleus CRH neurons’ regulatory pathway in acute...
Scientists from Xiangya Second Hospital reveal how hypothalamic CRH neurons regulate the sympathetic–neutrophil axis to protect against acute lung injury.
www.ebraincase.com
October 31, 2025 at 2:57 AM
braincase.bsky.social
🎃 Halloween Special | Spooky Savings on Viral Vectors!
🧬 AAV In-Stock (AAV5/8/9/Retro/PHP.eB) — 20–35% OFF + free 5 μl trial with 3+ buys!
🧫 RV & HSV — 20% OFF
🧠 Custom Packaging — up to 35% OFF
🎲 Mystery Box — 15 viral vectors, just $199!
👉 Shop Now: www.ebraincase.com/news/corpora...
🎃 Brain Case Biotech Halloween Promotion 2025
Enjoy up to 35% OFF on viral vectors! Global delivery & fast turnaround from Brain Case Biotech. Promotion ends Nov 9, 2025.
www.ebraincase.com
October 30, 2025 at 12:52 AM
braincase.bsky.social
✨🧠Breakthrough! Chinese scientists published in Cell: Gene-edited stem cells rejuvenate aging monkeys.
FOXO3-modified mesenchymal progenitor cells (SRCs) reduced aging biomarkers, improved brain and reproductive health, and showed anti-aging effects via exosomes.
🔗 www.ebraincase.com/support/lite...
Breakthrough! Chinese Team Publishes in Cell: Gene-Edited Stem Cells Rejuvenate Aging Monkeys
Chinese researchers developed FOXO3 gene-edited stem cells that reversed aging in primates. The study, published in Cell, reveals exosome-mediated systemic rejuvenation.
www.ebraincase.com
October 23, 2025 at 6:22 AM
braincase.bsky.social
✨🎉Excited to see our collaborator’s @piatkevich.bsky.social latest post!
The products are now available via Brain Case Biotech, supporting global neuroscience and gene therapy research.

🧠🔗Contact us at [email protected] for details
www.ebraincase.com/products-ser...

#AAVs #FRCaMPi #PiatkevichLab
piatkevich.bsky.social piatkevich.bsky.social @piatkevich.bsky.social · Oct 23
High-quality AAVs for red genetically encoded calcium indicator FRCaMPi are now available from BrainCase anywhere in the world www.ebraincase.com/products-ser...
October 23, 2025 at 2:36 AM
braincase.bsky.social
✨🎉Excited to see our [email protected] latest post!
The products are now available via Brain Case Biotech, supporting global neuroscience and gene therapy research.

🧠🔗Contact us at [email protected] for details.
www.ebraincase.com/products-ser...

#AAVs #FRCaMPi #PiatkevichLab
piatkevich.bsky.social piatkevich.bsky.social @piatkevich.bsky.social · Oct 23
High-quality AAVs for red genetically encoded calcium indicator FRCaMPi are now available from BrainCase anywhere in the world www.ebraincase.com/products-ser...
October 23, 2025 at 2:27 AM
braincase.bsky.social
🧠 Client Publication | Nature Communications
Prof. Zhong Chen’s and Academician Qingming Luo’s teams built a 3D single-synapse input atlas of histaminergic neurons in mice, revealing distinct LS and PVT circuit roles in REM sleep.
🧪 Viral tools from Brain Case.
👉 www.ebraincase.com/support/cust...
Client Publication | Nature Communications | Collaborative Study by Prof. Zhong Chen (Zhejiang Chinese Medical University) and Academician Qingming Luo (Hainan University) Maps Long-Range Inputs to Mo...
On August 29, the research team led by Prof. Zhong Chen and Qingming Luo published “A whole-brain male mouse atlas of long-range inputs to histaminergic neurons.”
www.ebraincase.com
October 21, 2025 at 3:58 AM
braincase.bsky.social
🔬 The patch-clamp technique enables precise recording of ion channel and neuronal activity—key for studying excitability and synaptic transmission.
Brain Case Biotech provides full patch-clamp recording & analysis for cells and brain tissue. 🔍 www.ebraincase.com/news/corpora...

#PatchClamp #Neural
Research Service | Cell and Tissue Patch-Clamp Recording and Analysis Services
Explore Brain Case Biotech’s cell and tissue patch-clamp recording services—offering precise ion channel, synaptic, and electrophysiological analysis for neuroscience
www.ebraincase.com
October 17, 2025 at 8:20 AM