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Reposted

stanfordbrain.bsky.social @stanfordbrain.bsky.social · 6h

Six @stanford.edu scientists, including Anne Brunet @brunetlab.bsky.social, have been awarded High-Risk, High-Reward Research program grants from the National Institutes of Health.

This will support Brunet's work on the peripheral nervous system, organs & aging.

news.stanford.edu/stories/2025...

Anne Brunet, the Michele and Timothy Barakett Professor of Genetics at Stanford Medicine and Wu Tsai Neurosciences Institute affiliate.

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brainresilience.bsky.social @brainresilience.bsky.social · 11h

Great talks at our recent seminar! Featuring:

Kristy Zera - Blocking the VLA4/VCAM1 axis prevents infarct-induced neurodegeneration by reducing neuroinflammation & promoting vascular integrity

Carla Shatz - Convergence of signals for pruning at a synaptic receptor implicated in Alzheimer's Disease

Dr. Kristy Zera gave a talk on “Blocking the VLA4/VCAM1 axis prevents infarct-induced neurodegeneration by reducing neuroinflammation and promoting vascular integrity" at the monthly Brain Resilience Seminar Series.

Dr. Carla Shatz gave a talk on “Convergence of signals for pruning at a synaptic receptor implicated in Alzheimer's disease" at the monthly Brain Resilience Seminar Series.

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Reposted

stanfordbrain.bsky.social @stanfordbrain.bsky.social · 7d

Great news! Our podcast, From Our Neurons to Yours, is a finalist for the Listener’s Choice Award in Science & Education at @signalawards.bsky.social!🎙️

Help us win and vote here by Oct. 9: vote.signalaward.com/PublicVoting...

The Signal Listener's Choice Award needs YOU

I just voted for this finalist to win a Signal Listener's Choice Award. You should too.

vote.signalaward.com

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brainresilience.bsky.social @brainresilience.bsky.social · 13d

Join us on Oct 9 at a symposium featuring brain resilience and aging research, including a clinical presentation with a patient’s perspective, poster session, and social! Registration required.

Stanford affiliates, sign up to present a poster by Oct 2.

brainresilience.stanford.edu/events/knigh...

Text: Knight Initiative for Brain Resilience, Wu Tsai Neurosciences Institute, Stanford University. Fall 2025 Symposium and Poster Session. October 9, 2025, 12:30 PM to 6:00 PM.

Image description: Digital Pathology. Oil Red O staining of a prefrontal cortex sample. It stains neutral lipids to assess lipid pathology. (triacylglycerols and sterol esters). The lipid staining gives an idea of lipid pathology to track a feature of brain aging. The red stains are positive stains (neutral lipid aggregates within cells). One of many stains that are possible. Image credit: Brain Resilience Lab.

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brainresilience.bsky.social @brainresilience.bsky.social · 22d

Amyloid beta and inflammation may converge on the LilrB2 receptor, according to new research led by Carla Shatz and supported by a Knight Initiative Catalyst Award. This may help explain synapse loss in Alzheimer’s.

Learn more: brainresilience.stanford.edu/news/buildin...

Building bridges between Alzheimer’s theories

A new study finds links between two popular models of the disease—and the results could change how

brainresilience.stanford.edu

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brainresilience.bsky.social @brainresilience.bsky.social · 29d

Our Brain Resilience Seminars are back! Yesterday, Jacob Simon shared his research on "A novel toolset for understanding neuromodulation," and Joe Winer discussed "Effects of ⍺-synuclein pathology in normal aging and Alzheimer’s disease." Thank you to all who joined and participated in the Q&A.

Jacob Simon presents his research on "A novel toolset for understanding neuromodulation."

Joe Winer presents his research on the "Effects of ⍺-synuclein pathology in normal aging and Alzheimer’s disease."

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brainresilience.bsky.social @brainresilience.bsky.social · Sep 5

Syed has been a vital part of our Brain Resilience Lab as the Primary Neuroanatomist and @stanfordmedicine.bsky.social’s Primary Brain Dissectionist & Coordinator, supporting research brains and rapid brain autopsies. He’s now beginning his PhD at the University of Washington . Congrats Syed!

Syed Bukhari, Primary Neuroanatomist, Brain Resilience Laboratory

brainresilience.bsky.social @brainresilience.bsky.social · Aug 28

Why do some dementia treatments work in mice but not in people?

At @stanfordneuro.bsky.social, Vanessa Langness, Danielle Simmons, and Frank Longo reviewed 400+ preclinical studies to identify key differences in timing, study design, and disease stage.

brainresilience.stanford.edu/news/why-pro...

Mice are often helpful for understanding human disease, yet promising tests in mice often don't translate to humans. A new study probes why.

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brainresilience.bsky.social @brainresilience.bsky.social · Aug 20

Researching the aging brain starts with knowing its structure.

Syed Bukhari, Primary Neuroanatomist at the Brain Resilience Lab, led a hands-on anatomy workshop for Stanford researchers—sharing expertise and building connections across the brain resilience community.

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brainresilience.bsky.social @brainresilience.bsky.social · Aug 15

In the Brain Resilience Lab, Shon has contributed to flagship projects that map the molecular landscape of brain aging and led collaborations using next-generation sequencing, histology & spatial transcriptomics. He’s now starting his neuroscience PhD at @ucsanfrancisco.bsky.social. Congrats Shon!

Shon Alimukhamedov, Research Associate, Brain Resilience Lab

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Reposted

stanfordbrain.bsky.social @stanfordbrain.bsky.social · Aug 4

Meet Emely Cisneros, a 2025 NeURO-CC Fellow!

A Biology major at Foothill College, Emely is exploring how research can inform care for aging populations in the lab of Tony Wyss-Coray under the mentorship of Marvin Reich.

Passionate about helping others, she aspires to pursue a career in medicine.

Emely Cisneros, 2025 Neurosciences Undergraduate Research Opportunity, Community College (NeURO-CC) Fellow

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brainresilience.bsky.social @brainresilience.bsky.social · Jul 31

By integrating innovative lysosomal omics and ferroptosis-targeted interventions, Dr. Monther Abu-Remaileh and Dr. Scott Dixon aim to identify strategies to restore lysosomal function, protect against neurodegeneration, and enhance brain resilience.

brainresilience.stanford.edu/our-science/...

2025 Catalyst Momentum Award. Mapping the cell-type-specific lysosomal content. PI: Monther Abu-Remaileh. Knight Initiative for Brain Resilience, Wu Tsai Neurosciences Institute, Stanford University.

2025 Catalyst Momentum Award. Mapping the cell-type-specific lysosomal content. Team member: Scott Dixon. Knight Initiative for Brain Resilience, Wu Tsai Neurosciences Institute, Stanford University.

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Reposted

stanfordbrain.bsky.social @stanfordbrain.bsky.social · Jul 25

Celebrate groundbreaking research by nominating a Stanford graduate student or postdoc for the 18th Annual Sammy Kuo Awards in Neuroscience!

Submit materials by this Monday, July 28 at 5pm (PT).

Learn more and nominate: neuroscience.stanford.edu/programs/com...

Photo of past Sammy Kuo awardees with Vincent V.C. Woo Director of Wu Tsai Neuro, Kang Shen.

Text: Nominations open. Sammy Kuo Awards in Neuroscience 2025. Deadline: Monday, July 28 at 5pm (PT).

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Reposted

stanfordbrain.bsky.social @stanfordbrain.bsky.social · Jul 16

Brain organoids are reshaping neuroscience. To scale up their work, Wu Tsai Neuro affiliates @sergiuppasca.bsky.social, Sarah Heilshorn & team found a solution: xanthan gum. This simple solution could accelerate the discovery of brain development & disease.

neuroscience.stanford.edu/news/common-...

Sergiu Pasca, the Kenneth T. Norris Jr. professor of psychiatry and behavioral sciences at Stanford Medicine and Uytengsu Family Director of the Stanford Brain Organogenesis Program.

Sarah Heilshorn, the Rickey/Nielsen Professor in the School of Engineering

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brainresilience.bsky.social @brainresilience.bsky.social · Jul 15

What makes the brain resilient, and how can research help more people stay cognitively healthy as they age?

Highlights include:
🧠 Early biomarkers
🧪 Lysosomal function
💉 Shingles vaccine & reduced dementia risk
📣 Lived experience
📊 72 Stanford posters

brainresilience.stanford.edu/news/knight-...

Marwa Zafarullah talks about her research poster with another person.

Elizabeth Mormino speaks at the Spring 2025 Brain Resilience Symposium.

A poster session gave 72 researchers a chance to discuss their research and its potential impact.

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brainresilience.bsky.social @brainresilience.bsky.social · Jul 9

“We’ve developed a blood-based indicator of the age of your organs,” said Tony Wyss-Coray. “With this indicator, we can assess the age of an organ today & predict the odds of your getting a disease associated with that organ 10 years later.”

Read more: med.stanford.edu/news/all-new...

Graphic design of a human body with clocks designed in place of intestines to symbolize organs aging at different speeds. Image credit: Tobias Wüstefeld.

Tony Wyss-Coray, PhD, professor of neurology and neurological sciences and director of the Knight Initiative for Brain Resilience at the Wu Tsai Neurosciences Institute

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Reposted

stanfordbrain.bsky.social @stanfordbrain.bsky.social · Jun 26

How has stroke research evolved, and where is it headed? In today's episode, physician-scientist @marionbuckwalter.bsky.social shares how decades of scientific discovery shaped what we know about stroke and why continued research is key to future progress.

neuroscience.stanford.edu/news/how-bas...

From Our Neurons to Yours, Wu Tsai Neurosciences Institute, Stanford University

Marion Buckwalter, MD, PhD, is a professor of neurology and neurological sciences and of neurosurgery at Stanford medicine, and a deputy director of the Wu Tsai Neurosciences Institute.

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Reposted

BrunetLab @brunetlab.bsky.social · Jun 25

Excited to share our review on Hallmark of Stem Cell Aging! With Tom Rando and Peggy Goodell @goodell-lab.bsky.social!!

www.sciencedirect.com/science/arti...

Hallmarks of stem cell aging

As organisms age, somatic stem cells progressively lose their ability to sustain tissue homeostasis and support regeneration. Although stem cells are …

www.sciencedirect.com

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brainresilience.bsky.social @brainresilience.bsky.social · Jun 25

Why do some older adults remember better than others, even when equally healthy? A new Knight-supported study led by Jintao Sheng & Anthony Wagner shows 2 distinct pathways that shape memory in aging:
🧠Early Alzheimer’s tau
🧠Moment-to-moment attention

🔗 brainresilience.stanford.edu/news/two-roa...

Brain scan images with some regions highlighted in reds and blues.

Jintao Sheng, Brain Resilience Postdoctoral Research Fellow, Psychology

Anthony Wagner, Lucie Stern Professor in the Department of Psychology, Deputy Director of Stanford’s Wu Tsai Neurosciences Institute

Elizabeth Mormino, Associate Professor, Neurology & Neurological Sciences

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brainresilience.bsky.social @brainresilience.bsky.social · Jun 23

Stanford scientists are uncovering the cellular functions that go awry in degenerative brain disorders and identifying therapies that could treat them in the lab of chemical engineer and Knight Initiative affiliate Monther Abu-Remaileh @abu-remaileh.bsky.social.

🔗 news.stanford.edu/stories/2025...

Monther Abu-Remaileh, Assistant Professor of Chemical Engineering and of Genetics, Institute Scholar at Sarafan ChEM-H, Knight Initiative for Brain Resilience supported researcher

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Reposted

stanfordbrain.bsky.social @stanfordbrain.bsky.social · Jun 23

Stanford research by Dr Barres changed our understanding of myelin—once seen as static insulation, now linked to learning & memory. Learn how @michellemonje.bsky.social, @erinmgibson.bsky.social, @bradzuchero.bsky.social & others continue to shape the field: neuroscience.stanford.edu/news/underst...

A dark ring of myelin in a black and white image of a cell. Image courtesy of Michelle Monje.

Erin Gibson examines an electron microscope image of rings of myelin surrounding an axon.

Michelle Monje’s lab has used electron microscopy to study rings of myelin surrounding an axon.

Brad Zuchero (wearing a Ben Barres T-shirt) and Husniye Kantarci

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Reposted

stanfordbrain.bsky.social @stanfordbrain.bsky.social · Jun 11

How does the brain map where rewards are found?

Stanford researchers Lisa Giocomo and Mari Sosa found that mice form adaptable hippocampal maps that track reward locations, offering insight into how memory, dementia & addiction relate to place and reward.

neuroscience.stanford.edu/news/locatio...

A section of the mouse hippocampus illustrates where cells were genetically engineered to fluoresce when active using GCaMP, a genetically encoded calcium indicator commonly used to image brain activity. Image credit: Giocomo Lab

Lisa Giocomo is a professor of neurobiology, HHMI Investigator, and Wu Tsai Neuro deputy director whose laboratory studies how single brain cells and dynamic networks interact to enable spatial memory and navigation.

Marielena Sosa is a postdoctoral scientist in the Giocomo lab who led the work with former graduate student Mark Plitt.

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brainresilience.bsky.social @brainresilience.bsky.social · Jun 10

Tanya Paull of @utaustin.bsky.social gave a talk on "DNA damage and cerebellar ataxia: roles for transcription stress, PARP, and R-loops in ATM-associated neurodegeneration" in an Aging Research seminar organized by the Knight Initiative and the Paul F. Glenn Center for Biology of Aging Research.

Tanya T. Paull, Burl G. and Lorene L. Rogers Chair in Human Health, Professor of Oncology, gives a talk on "DNA damage and cerebellar ataxia: roles for transcription stress, PARP, and R-loops in ATM-associated neurodegeneration."

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brainresilience.bsky.social @brainresilience.bsky.social · Jun 9

What does surgery reveal about brain resilience?

Anesthesiologists Martin Angst & Igor Feinstein are studying older adults before, during & after cardiac surgery to explore how stress impacts the brain—why some recover cognitively while others decline.

brainresilience.stanford.edu/news/under-l...

Debbie Styles smiles with her surgical team. Standing, from left to right: Tiffany, a research coordinator for the CARDIAC-PND Study, Dr. Martin Angst, and Dr. Igor Feinstein.

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brainresilience.bsky.social @brainresilience.bsky.social · Jun 4

At a recent seminar, Hannah Ennerfelt shared a talk on "Peripheral immune drivers of cognitive decline in aging and Alzheimer's disease," and Jintao Sheng discussed "Top-down attention & Alzheimer’s pathology impact cortical selectivity during learning, influencing episodic memory in older adults."

Hannah Ennerfelt shares her research on "Peripheral immune drivers of cognitive decline in aging and Alzheimer's disease."

Jintao Sheng shares her research on "Top-down attention and Alzheimer’s pathology impact cortical selectivity during learning, influencing episodic memory in older adults."

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