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Ageing and remyelination failure in people with multiple sclerosis - PubMed

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 6h

If you are too old, is it impossible remyelinate? NO! "There does not appear to be an age cut-off beyond which remyelination is not possible, as there are pathological data supporting remyelination occurring, to some extent, across all ages." pubmed.ncbi.nlm.nih.gov/41048166/

One of the most promising strategies to delay, prevent, or reverse disability progression in multiple sclerosis (MS) is enhancing endogenous remyelination. While preclinical research has established a...

pubmed.ncbi.nlm.nih.gov

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 6h

14.3 % of people with MS have paramagnetic rim lesions (PRLs) (dark rim on SWI sequence) which correlate with higher disability [data from Norway] pmc.ncbi.nlm.nih.gov/articles/PMC...

Man who became popular in Blinking White Guy gif raises over $300,000 for multiple sclerosis research

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 7h

Drew Scanlon, the man with the famous bewildered blinking meme in 2013 has managed to raise over $300,000 for multiple sclerosis in fundraising bicycle races over the years. One of his friends has the condition. www.theguardian.com/us-news/2025...

Drew Scanlon, a resident of San Francisco, said the case was close to him a friend and his mother are afflicted with it

www.theguardian.com

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Reposted

MS Sucks 🎗 @itreallydoes.com · 22h

www.youtube.com/watch?v=oxd3...

Dr. Beaber always does a great job translating the data for us medically challenged. Follow him if you already don't: @brandon-beaber.bsky.social

Multiple Sclerosis Starts Years Before Symptom Onset

Does Obesity Make Multiple Sclerosis Get Worse Faster?

www.youtube.com

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brandon-beaber.bsky.social @brandon-beaber.bsky.social · 2d

Does Obesity Make Multiple Sclerosis Get Worse Faster? Very important data shared by @aaronbostermd.bsky.social youtu.be/9UJXK_tKqUg?...

YouTube video by Aaron Boster MD

youtu.be

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brandon-beaber.bsky.social @brandon-beaber.bsky.social · 3d

The published MS-STAT2 trial, a phase 3, randomized, double-blind, placebo-controlled trial which DID NOT show any benefit of high dose simvastatin in preventing disability progression in progressive MS. pubmed.ncbi.nlm.nih.gov/41045938/

ECTRIMS 2025: Standard Ocrevus dose holds up in PPMS

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 3d

Higher doses of ocrevus were not more effective than standard doses in the Phase 3b GAVOTTE trial multiplesclerosisnewstoday.com/ectrims/2025...

Topline trial data showed that a higher Ocrevus dose didn't provide more benefit than the standard regimen in people with PPMS.

multiplesclerosisnewstoday.com

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brandon-beaber.bsky.social @brandon-beaber.bsky.social · 3d

Ocrevus was superior to gilenya in pediatric MS in a head to head trial (OPERETTA 2 trial) with 48% fewer relapses (annual relapse rate of 0.07 vs 0.14) along with "greater reductions in disease activity on brain imaging." www.medscape.com/viewarticle/...

Head-to-Head Trial Supports New Treatment for Kids With MS

A multicenter phase 3 trial comparing ocrelizumab to fingolimod for children with MS achieved its noninferiority primary endpoint while suggesting potential safety advantages.

www.medscape.com

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brandon-beaber.bsky.social @brandon-beaber.bsky.social · 5d

Various gastrointestinal diseases are more common 5 years prior to MS “symptom onset” (from BC Canada), arguably part of the MS "prodrome" pmc.ncbi.nlm.nih.gov/articles/PMC...

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 6d

Birth rates decline in women and men who are subsequently diagnosed with MS about 3 years prior to "symptom onset."

IRIS without PML in MS patients – a case report of IRIS after past alemtuzumab therapy with subsequent oral cladribine treatment and review of the literature

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 7d

Lemtrada can lead to long term remission in MS, but not always. This is a case report of a 42 year old man who developed speech difficulty, agitation after 8 years of remission and was found to have "Immune reconstitution inflammatory syndrome" www.aaem.pl/IRIS-without...

Alemtuzumab is a high-efficacy drug for relapsing-remitting multiple sclerosis (MS), leading to non-selective reconstitution of the immune system. Immune reconstitution inflammatory syndrome (IRIS) de...

www.aaem.pl

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brandon-beaber.bsky.social @brandon-beaber.bsky.social · 7d

Rate of different symptoms in multiple sclerosis (data from Poland) link.springer.com/article/10.1...

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brandon-beaber.bsky.social @brandon-beaber.bsky.social · 7d

Types of Brain Scans Explained by Neurologist youtu.be/ePN_kHzfJDg?...

Types of Brain Scans Explained by Neurologist

Unlocking Multiple Sclerosis Genetics | Neurology

youtu.be

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brandon-beaber.bsky.social @brandon-beaber.bsky.social · 9d

"We found to a gene which predicts MS prognosis!" Beware of this highly dubious claim in scientific publications as very frequently, a replication study fails to recapitulate the finding (table 5 of the linked article). www.neurology.org/doi/10.1212/...

Multiple sclerosis (MS) is a clinically diverse and unpredictable CNS disorder. The considerable heterogeneity in disease course between people with MS is believed to reflect the varying magnitude and...

www.neurology.org

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brandon-beaber.bsky.social @brandon-beaber.bsky.social · 9d

Researchers from Turkey report double the prevalence of MS in regions with high radon gas exposure (~1 in 2400 compared to 1 in 4900 in areas with low radon gas exposure). Whether this is a causal association or due to confounding is unknown. pubmed.ncbi.nlm.nih.gov/41012418/

The Effect of Radon Concentration on MS Prevalence: A Door-to-Door Survey in the Fault Zone in Afyonkarahisar, Turkey - PubMed

<span><b>Background:</b> Despite the identification of various environmental factors that increase the risk of multiple sclerosis (MS), the effects of many factors on the etiology of MS remain to be e...

pubmed.ncbi.nlm.nih.gov

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 9d

Use of disease modifying therapies for MS over time. The use of highly effective b-cell depleting therapies is rapidly increasing (Data from France). pubmed.ncbi.nlm.nih.gov/41014778/

Clemastine as a Remyelinating Agent

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 9d

Paramagnetic rim lesions (PRLs) [dark lesions on SWI sequences in multiple sclerosis] appear to be a phenomenon associated with relatively newer lesions. In this study, PRLs were only present in lesions formed within the last 5 years. pubmed.ncbi.nlm.nih.gov/41019415/

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brandon-beaber.bsky.social @brandon-beaber.bsky.social · 12d

Clemastine as a Remyelinating Agent youtube.com/shorts/L8GtO...

youtube.com

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brandon-beaber.bsky.social @brandon-beaber.bsky.social · 14d

A treatment for Huntington's Disease? The open label phase 2 PIVOT-HD study of PTC518 (votoplam, a gene therapy) showed reduction of neurofilament light chain and reduced disability progression, compared to historical control group, not a randomized trial ir.ptcbio.com/news-release...

ir.ptcbio.com

Best Multiple Sclerosis Medicine for Preventing Disability

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 14d

Best Multiple Sclerosis Medicine for Preventing Disability youtu.be/3wstm5izx2o?...

Amaurosis Fugax Dolorosa: A Prodromal Syndrome in Optic Neuritis Associated With Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease - PubMed

youtu.be

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brandon-beaber.bsky.social @brandon-beaber.bsky.social · 15d

Painful brief vision loss can precede typical optic neuritis associated with Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD) dubbed "Amaurosis Fugax Dolorosa." This case series describes 8 such instances (out of 350 with MOGAD) pubmed.ncbi.nlm.nih.gov/40982779/

Painful AF is a previously unrecognized and specific prodrome of MOGAD-associated ON; identifying this rare presentation may enable earlier diagnosis and treatment.

pubmed.ncbi.nlm.nih.gov

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 15d

About half of people with multiple sclerosis have Paramagnetic Rim Lesions according this meta analysis. They are associated with smouldering inflammation and microglial activation. pubs.rsna.org/doi/10.1148/...

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 15d

Kappa free light chain index is probably SLIGHTLY associated with worse prognosis in multiple sclerosis (image is YES/NO new brainstem and spinal cord lesions) link.springer.com/article/10.1...