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Brian Rifkin @brianrifkin.bsky.social · 14h

The Näirb is a three leg stool that comes in black and the original oak. Perfect for sitting at low tables to compose depressing poetry about environmental destruction.

a group of people are playing drums on a stage while a man holds a chair over his head .

ALT: a group of people are playing drums on a stage while a man holds a chair over his head .

media.tenor.com

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Brian Rifkin @brianrifkin.bsky.social · 14h

a woman wearing glasses and a tank top that says stick giggle actually

ALT: a woman wearing glasses and a tank top that says stick giggle actually

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Brian Rifkin @brianrifkin.bsky.social · 16h

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Reposted by Brian Rifkin

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 1d

Another baxdrostat new/press release www.reuters.com/business/hea...

Not sure how different these findings are from this: www.nephjc.com/news/2025/9/... covered by @brianrifkin.bsky.social

Funniest nugget, AZ expects $5 billion sales 😂.

If that truly happens it will be a spiro-shame 😭

ASIs Advance: NephJC Shorts on BaxHTN — NephJC

A NephJC short on the latest baxdrostat trial

www.nephjc.com

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Brian Rifkin @brianrifkin.bsky.social · 1d

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Brian Rifkin @brianrifkin.bsky.social · 1d

Hmm, interesting take. I’m not sure we ever had good evidence that “low” protein diets were more than theoretically beneficial in CKD (I never recommended them). Having said that I’m all for #glipination and MORE protein!!

a cartoon character from the simpsons is holding a bottle of protein

ALT: a cartoon character from the simpsons is holding a bottle of protein

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Reposted by Brian Rifkin

Nephrology Journal Club @nephjc.bsky.social · 1d

1/10
Welcome to #TenPostNephJC
Last #NephJC we discussed tolerance induction in HLA matched 🫘 transplants with donor Hematopoietic stem cells (MDR-101).
Missed the Chimeri-chat? No worries - We’re quite “tolerant” to those who missed their IS(Informative Session)!

pubmed.ncbi.nlm.nih.gov/39922283/

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Reposted by Brian Rifkin

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 1d

TREGs get the @nobelprize.bsky.social

www.nobelprize.org/prizes/medic...

Immune tolerance back in the news

#NephSky #Transplant

Nobel Prize in Physiology or Medicine 2025

The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

www.nobelprize.org

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Brian Rifkin @brianrifkin.bsky.social · 1d

#NephJC 🥇

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Reposted by Brian Rifkin

mindi @flawdbizkit.bsky.social · 2d

what he said✨✨✨

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Brian Rifkin @brianrifkin.bsky.social · 2d

Perhaps we can help! Great commentary by @nephroseeker.bsky.social

www.nephjc.com/news/2025/30...

Immune tolerance in kidney transplantation: from first principles to clinical engineering — NephJC

A commentary putting the chimerism and immune tolerance in perspective

www.nephjc.com

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Brian Rifkin @brianrifkin.bsky.social · 2d

See…we are cutting edge 🏆 #NephJC

www.nephjc.com/news/chimera...

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Reposted by Brian Rifkin

The Associated Press @apnews.com · 2d

BREAKING: Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi win the Nobel Prize in medicine for work on peripheral immune tolerance.

The Nobel Prize in medicine goes to 3 scientists for work on peripheral immune tolerance

Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi have won the Nobel Prize in medicine for their discoveries about peripheral immune tolerance.

bit.ly

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Brian Rifkin @brianrifkin.bsky.social · 2d

Hmm. It’s a Facebook link to a Facebook fundraiser. You can also give at the Diabetes Foundation of Mississippi (and DM so I can match it):

www.msdiabetes.org

Diabetes Foundation of Mississippi | Ridgeland, MS

Living life without limits is what the Diabetes Foundation of Mississippi (DFM) believes is possible for all those who have diabetes. Every dollar raised by the DFM stays in Mississippi to go toward e...

www.msdiabetes.org

Brian Rifkin @brianrifkin.bsky.social · 2d

This year marks 30 years as a type 1 diabetic.
I am raising money this month for backpacks with supplies for new diabetics ($300) & hypoglycemia boxes for schools ($100).
Goal is to raise $6K.
I will match $6K for a total of 30 🎒& 30📦
Thanks 😊

www.facebook.com/share/1771mmSvjH/?mibextid=wwXIfr

Redirecting...

www.facebook.com

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Brian Rifkin @brianrifkin.bsky.social · 2d

Yes, no, yes. Wait a minute…YES!!!

a woman in a very nice selection dress is standing in a room

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Brian Rifkin @brianrifkin.bsky.social · 3d

When did we even start caring about who appointed which judge?? Aren’t judges supposed to be impartial and passionlessly enforce the law?

a superhero holding a book with the words " justice is blind not heartless "

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Brian Rifkin @brianrifkin.bsky.social · 3d

Sorry could resist 😜

donald trump is giving a speech and saying i know words on i have the best words .

ALT: donald trump is giving a speech and saying i know words on i have the best words .

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Brian Rifkin @brianrifkin.bsky.social · 4d

War ravaged????

a woman is wearing a knight costume and helmet .

ALT: a woman is wearing a knight costume and helmet .

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Brian Rifkin @brianrifkin.bsky.social · 4d

a man in a military uniform says right to jail right away .

ALT: a man in a military uniform says right to jail right away .

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Brian Rifkin @brianrifkin.bsky.social · 4d

Sending good vibes and thoughts.
See you next week!

a cartoon illustration of a message being sent from me to you .

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Brian Rifkin @brianrifkin.bsky.social · 4d

See I told you immune tolerance wasn’t the answer. Modifying antigens on donor kidneys makes much more sense (and won’t wear off).

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Reposted by Brian Rifkin

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 4d

interesting interview with Mineralys CEO (aka Lorundrostat maker) on @statnews.com
www.statnews.com/sponsor/2025...

I am not sure there is any role for this class beyond difficult PA given spiro and finerenone

Can a new class of drugs finally control hypertension in millions of patients?

In this Q&A, Mineralys CEO Jon Congleton discusses how targeting aldosterone could reshape hypertension treatment. Aldosterone synthase inhibitors

www.statnews.com

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Brian Rifkin @brianrifkin.bsky.social · 4d

As we said, where do ASIs fit?

www.nephjc.com/news/2025/9/24/baxdrostat

ASIs Advance: NephJC Shorts on BaxHTN — NephJC

A NephJC short on the latest baxdrostat trial

www.nephjc.com

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Reposted by Brian Rifkin

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 4d

Strange papers

Cost-effectiveness analysis in @jama.com JNO

jamanetwork.com/journals/jam...
Seems to suggest standard (versus early) dialysis in AKI is more expensive? (It was still cost effective)
Which is strange considering in STARRTAKI there was *less* dialysis in standard

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